肿瘤作为胚胎学现象及其在动物进化和癌症起源中的意义。I. 肿瘤过程及其与细胞融合和生殖细胞形成的关系
The Neoplasia as embryological phenomenon and its implication in the animal evolution and the origin of cancer. I. A presentation of the neoplastic process and its connection with cell fusion and germline formation
AI总结：
本文探讨肿瘤作为胚胎学现象在动物进化和癌症起源中的作用，提出肿瘤过程与细胞融合及生殖细胞形成有关，并追溯肿瘤形成在进化中的起源。
摘要：
胚胎学在理解动物形态进化中的决定性作用根植于科学史。多细胞性形成离不开第一个胚胎的形成。本文推测埃迪卡拉纪海洋的生物物理现象和环境在最早合子核中招募了肿瘤功能模块（NFM）。肿瘤过程作为具有深远胚胎学意义的生物现象，成为促进第一个胚胎和癌症形成以及在不同动物群体中创造和重塑身体形状的进化引擎。本文深入反思了首次胚胎发生物理学及其对额外NFM组件（如细胞外基质）的适应性贡献。了解NFM的成分、结构、动态和起源有助于理解胚胎通过肿瘤在进化辐射中创造动物形式的多种可能性和创新。肿瘤发育路径起源于栉水母，并在哺乳动物和其他顶端群体中巩固。
英文摘要：
The decisive role of Embryology in understanding the evolution of animal forms is founded and deeply rooted in the history of science. It is recognized that the emergence of multicellularity would not have been possible without the formation of the first embryo. We speculate that biophysical phenomena and the surrounding environment of the Ediacaran ocean were instrumental in co-opting a neoplastic functional module (NFM) within the nucleus of the first zygote. Thus, the neoplastic process, understood here as a biological phenomenon with profound embryologic implications, served as the evolutionary engine that favored the formation of the first embryo and cancerous diseases and allowed to coherently create and recreate body shapes in different animal groups during evolution. In this article, we provide a deep reflection on the Physics of the first embryogenesis and its contribution to the exaptation of additional NFM components, such as the extracellular matrix. Knowledge of NFM components, structure, dynamics, and origin advances our understanding of the numerous possibilities and different innovations that embryos have undergone to create animal forms via Neoplasia during evolutionary radiation. The developmental pathways of Neoplasia have their origins in ctenophores and were consolidated in mammals and other apical groups.
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