解构细胞骨架交叉连接中的熵、主动和摩擦力
Disentangling Entropic, Active, and Frictional Forces in Cytoskeletal Crosslinking
AI总结：
本文提出了一种理论框架，用于解构细胞骨架交叉连接中熵、主动和摩擦力的相互作用，以解释交叉连接蛋白如何集体产生力。
摘要：
细胞内由驱动型和被动型交叉连接蛋白混合产生的力是主动细胞力学的关键驱动力。尽管其重要性，目前尚缺乏统一的理论来描述此类交叉连接力。在本文中，我们推导出一种理论，该理论利用非平衡热力学，通过可测量的纤维和交叉连接器属性，预测由连接两个生物聚合物纤维的交叉连接蛋白集体产生的力。我们的框架使我们能够将交叉连接器产生的力分解为三个独立的组成部分：熵、主动和摩擦力。通过这样做，它为交叉连接蛋白自我组织和集体产生力的基本机制提供了清晰的物理解释。我们通过将其应用于四个不同的实验来展示该框架的稳健性和实用性，这些实验探讨了被动和驱动型交叉连接器的综合作用。对于每个实验，我们的理论方法使我们能够分离熵、主动和摩擦力的相对贡献，阐明不同物理过程如何支撑集体力的产生。反过来，这使得能够定量比较和预测各种交叉连接器组合如何影响纤维之间的力生成、纤维上的图案形成以及纤维对的动力学。
英文摘要：
The forces that mixtures of motorized and passive crosslinking proteins collectively generate between cytoskeletal filaments within our cells are the key drivers of active cellular mechanics. Despite their importance, a unified theory to describe such crosslinking forces has so far been missing. In this paper, we derive a theory that predicts the forces generated collectively by crosslinking proteins linking two biopolymer filaments from measurable filament and crosslinker properties, using out-of-equilibrium thermodynamics. Our framework allows us to decompose the forces generated by crosslinkers into three separate components: entropic, active, and frictional. In doing so, it offers a clear physical interpretation of the fundamental mechanisms by which crosslinking proteins self-organize and collectively generate forces. We demonstrate the robustness and utility of this framework by applying it to four different experiments that probe the combined roles of passive and motorized crosslinkers. For each experiment, our theoretical approach allows us to disentangle the relative contributions of entropic, active, and frictional forces, clarifying how different physical processes underpin collective force production. In turn, this makes it possible to quantitatively compare and predict how various crosslinker combinations influence force generation between filaments, pattern formation along filaments, and the dynamics of filament pairs.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
