Simultaneous recording of electroencephalography (EEG) and functional MRI (fMRI) can provide a more complete view of brain function by merging high temporal and spatial resolutions. This proof-of-concept study presents initial evidence for the feasibility of simultaneous EEG-fMRI at 0.55T in a visual task. We characterize the gradient and ballistocardiogram (BCG) artifacts inherent to this environment and demonstrate that the lower field strength suggests a reduction in the magnitude of the BCG artifact compared to high-field (1.5T, 3T, 7T) systems. This reduction shows promise for facilitating effective denoising while preserving signal integrity. Furthermore, we tested a multimodal integration pipeline that uses the EEG power envelope to compute a predictor of the hemodynamic BOLD response, demonstrating the potential for EEG-based estimation of neurovascular coupling in this environment. We demonstrate that combined EEG-fMRI at 0.55T is feasible and represents a promising environment for multimodal neuroimaging.
Objective. EEG data collected during fMRI acquisition are contaminated with MRI gradients and ballistocardiogram (BCG) artifacts, in addition to artifacts of physiological origin. There have been several attempts for reducing these artifacts with manual and time-consuming pre-processing, which may result in biasing EEG data due to variations in selecting steps order, parameters, and classification of artifactual independent components. Thus, there is a strong urge to develop a fully automatic and comprehensive pipeline for reducing all major EEG artifacts. In this work, we introduced an open-a…
Simultaneous EEG-fMRI is a multi-modal neuroimaging technique that provides complementary spatial and temporal resolution for inferring a latent source space of neural activity. In this paper we address this inference problem within the framework of transcoding -- mapping from a specific encoding (modality) to a decoding (the latent source space) and then encoding the latent source space to the other modality. Specifically, we develop a symmetric method consisting of a cyclic convolutional transcoder that transcodes EEG to fMRI and vice versa. Without any prior knowledge of either the hemodyna…
Augmenting interictal mapping with neurovascular coupling biomarkers by structured factorization of epileptic EEG and fMRI data
KU Leuven（鲁汶大学）；Leuven Brain Institute（鲁汶脑科学研究所）；Maastricht UMC+（马斯特里赫特大学医学中心+）；University Hospitals Leuven（鲁汶大学医院）；Delft University of Technology（代尔夫特理工大学）
Classifying EEG responses to naturalistic acoustic stimuli is of theoretical and practical importance, but standard approaches are limited by processing individual channels separately on very short sound segments (a few seconds or less). Recent developments have shown classification for music stimuli (~2 mins) by extracting spectral components from EEG and using convolutional neural networks (CNNs). This paper proposes an efficient method to map raw EEG signals to individual songs listened for end-to-end classification. EEG channels are treated as a dimension of a [Channel x Sample] image tile…
Design and Validation of a Portable EEG-tES Platform Supporting High-Rate EEG Recording and Temporal Interference Stimulation
College of Computer Science and Technology, Zhejiang University（浙江大学计算机科学与技术学院）；State Key Laboratory of Brain-machine Intelligence, Zhejiang University（浙江大学脑机智能全国重点实验室）；Zhejiang Qiangnao Technology Co., Ltd.（浙江强脑科技有限公司）
EOG Artifact Removal from Single and Multi-channel EEG Recordings through the combination of Long Short-Term Memory Networks and Independent Component Analysis
Sharif University of Technology（谢里夫理工大学）；University of Toronto（多伦多大学）；University Health Network（大学医疗网络）；Amirkabir University of Technology（阿米尔卡比尔理工大学）
Tokyo University of Agriculture and Technology（东京农工大学）；Juntendo University Nerima Hospital（顺天堂大学练马医院）
Electroencephalography (EEG) is essential for the diagnosis of epilepsy, but it requires expertise and experience to identify abnormalities. It is thus crucial to develop automated models for the detection of abnormalities in EEGs related to epilepsy. This paper describes the development of a novel class of compact convolutional neural networks (CNNs) for detecting abnormal patterns and electrodes in EEGs for epilepsy. The designed model is inspired by a CNN developed for brain-computer interfacing called multichannel EEGNet (mEEGNet). Unlike the EEGNet, the proposed model, mEEGNet, has the sa…
CATD: Unified Representation Learning for EEG-to-fMRI Cross-Modal Generation
Southern University of Science and Technology（南方科技大学）；Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；Uppsala University（乌普萨拉大学）；King Fahd University of Petroleum and Minerals（法赫德国王石油与矿业大学）；Maebashi Institute of Technology（前桥工业大学）；Chongqing University of Posts and Telecommunications（重庆邮电大学）；Shenzhen University（深圳大学）
Rensselaer Polytechnic Institute（伦斯勒理工学院）；IBM Thomas J. Watson Research Center（IBM托马斯·J·沃森研究中心）；Mount Sinai Hospital（西奈山医院）
Electroencephalogram (EEG) is a prominent way to measure the brain activity for studying epilepsy, thereby helping in predicting seizures. Seizure prediction is an active research area with many deep learning based approaches dominating the recent literature for solving this problem. But these models require a considerable number of patient-specific seizures to be recorded for extracting the preictal and interictal EEG data for training a classifier. The increase in sensitivity and specificity for seizure prediction using the machine learning models is noteworthy. However, the need for a signi…
We propose a deep learning approach to predicting audio event onsets in electroencephalogram (EEG) recorded from users as they listen to music. We use a publicly available dataset containing ten contemporary songs and concurrently recorded EEG. We generate a sequence of onset labels for the songs in our dataset and trained neural networks (a fully connected network (FCN) and a recurrent neural network (RNN)) to parse one second windows of input EEG to predict one second windows of onsets in the audio. We compare our RNN network to both the standard spectral-flux based novelty function and the …
Cardiff University（卡迪夫大学）；University of the West of England（西英格兰大学）
The classification of electroencephalography (EEG) signals is useful in a wide range of applications such as seizure detection/prediction, motor imagery classification, emotion classification and drug effects diagnosis, amongst others. With the large number of EEG channels acquired, it has become vital that efficient data-reduction methods are developed, with varying importance from one application to another. It is also important that online classification is achieved during EEG recording for many applications, to monitor changes as they happen. In this paper we introduce a method based on Mu…
Electroencephalographic (EEG) recordings are often contaminated by electromyographic (EMG) artifacts, especially when recording during movement. Existing methods to remove EMG artifacts include independent component analysis (ICA), and other high-order statistical methods. However, these methods can not effectively remove most of EMG artifacts. Here, we proposed a modified ICA model for EMG artifacts removal in the EEG, which is called EMG Removal by Adding Sources of EMG (ERASE). In this new approach, additional channels of real EMG from neck and head muscles (reference artifacts) were added …
Quantity versus Diversity: Influence of Data on Detecting EEG Pathology with Advanced ML Models
Faculty of Physics, University of Warsaw（华沙大学物理学院）；Automotive Industry Institute, Łukasiewicz Research Network（卢卡谢维茨研究网络汽车工业研究所）；Nencki Institute of Experimental Biology, Polish Academy of Sciences（波兰科学院Nencki实验生物学研究所）；WIT Academy（WIT学院）；Elmiko Biosignals sp. z o.o.（Elmiko Biosignals有限责任公司）
Several Convolutional Deep Learning models have been proposed to classify the cognitive states utilizing several neuro-imaging domains. These models have achieved significant results, but they are heavily designed with millions of parameters, which increases train and test time, making the model complex and less suitable for real-time analysis. This paper proposes a simple, lightweight CNN model to classify cognitive states from Electroencephalograph (EEG) recordings. We develop a novel pipeline to learn distinct cognitive representation consisting of two stages. The first stage is to generate…
Objective: To develop and validate an automated method for bedside monitoring of sleep state fluctuations in neonatal intensive care units. Methods: A deep learning -based algorithm was designed and trained using 53 EEG recordings from a long-term (a)EEG monitoring in 30 near-term neonates. The results were validated using an external dataset from 30 polysomnography recordings. In addition to training and validating a single EEG channel quiet sleep detector, we constructed Sleep State Trend (SST), a bedside-ready means for visualizing classifier outputs. Results: The accuracy of quiet sleep de…
Recording Brain Activity While Listening to Music Using Wearable EEG Devices Combined with Bidirectional Long Short-Term Memory Networks
School of Music, Jiangxi Normal University（江西师范大学音乐学院）；School of Electronic Information, HuZhou College（湖州学院电子信息学院）；San Francisco State University（旧金山州立大学）
Clinical Feasibility of Smartphone-based EEG in Kenya
BrainCapture；Technical University of Denmark（丹麦技术大学）；Kenyatta University Teaching, Referral and Research Hospital（肯雅塔大学教学、转诊和研究中心医院）；Copenhagen University Hospital Rigshospitalet（哥本哈根大学医院利格什皮塔莱特医院）；Children's Hospital Srebrnjak（斯雷布伦亚克儿童医院）；"Prof. Dr. Alexandru Obregia" Psychiatry Hospital（亚历山大·奥布雷吉亚教授博士精神病医院）；Danish Epilepsy Center, Filadelfia（丹麦癫痫中心菲拉德尔菲亚）；University of Copenhagen（哥本哈根大学）
Neural networks often obtain sub-optimal representations during training, which degrade robustness as well as classification performances. This is a severe problem in applying deep learning to bio-medical domains, since models are vulnerable to being harmed by irregularities and scarcities in data. In this study, we propose a pre-training technique that handles this challenge in sleep staging tasks. Inspired by conventional methods that experienced physicians have used to classify sleep states from the existence of characteristic waveform shapes, or template patterns, our method introduces a c…
Window Stacking Meta-Models for Clinical EEG Classification
University of the West of England（西英格兰大学）；University College London Hospitals NHS Foundation Trust（伦敦大学学院医院NHS基金会信托）；North Bristol NHS Trust（北布里斯托尔NHS信托）
The electroencephalography (EEG), which is one of the easiest modes of recording brain activations in a non-invasive manner, is often distorted due to recording artifacts which adversely impacts the stimulus-response analysis. The most prominent techniques thus far attempt to improve the stimulus-response correlations using linear methods. In this paper, we propose a neural network based correlation analysis framework that significantly improves over the linear methods for auditory stimuli. A deep model is proposed for intra-subject audio-EEG analysis based on directly optimizing the correlati…
Integration of Simultaneous Resting-State Electroencephalography, Functional Magnetic Resonance Imaging, and Eye-Tracker Methods to Determine and Verify Electroencephalography Vigilance Measure
National Tsing Hua University（台湾清华大学）；National Taiwan Ocean University（台湾海洋大学）；Elan Microelectronics Corporation（义隆电子股份有限公司）；University of California, San Diego（加利福尼亚大学圣迭戈分校）
Electroencephalography (EEG) signals are often contaminated with artifacts. It is imperative to develop a practical and reliable artifact removal method to prevent misinterpretations of neural signals and underperformance of brain-computer interfaces. This study developed a new artifact removal method, IC-U-Net, which is based on the U-Net architecture for removing pervasive EEG artifacts and reconstructing brain sources. The IC-U-Net was trained using mixtures of brain and non-brain sources decomposed by independent component analysis and employed an ensemble of loss functions to model comple…
Frankfurt Institute for Advanced Studies (FIAS)（法兰克福高等研究院（FIAS））；Goethe University Frankfurt（法兰克福歌德大学）；Center for Personalized Translational Epilepsy Research (CePTER)（个性化转化癫痫研究中心（CePTER））；Oscar Langendorff Institute of Physiology, Rostock University Medical Center（罗斯托克大学医学中心奥斯卡·朗根多夫生理研究所）；Royal College of Surgeons Ireland（爱尔兰皇家外科医学院）
Epilepsy is one of the most common neurological disorders, affecting about 1% of the population at all ages. Detecting the development of epilepsy, i.e., epileptogenesis (EPG), before any seizures occur could allow for early interventions and potentially more effective treatments. Here, we investigate if modern machine learning (ML) techniques can detect EPG from intra-cranial electroencephalography (EEG) recordings prior to the occurrence of any seizures. For this we use a rodent model of epilepsy where EPG is triggered by electrical stimulation of the brain. We propose a ML framework for EPG…
How Much Data is Enough? Optimization of Data Collection for Artifact Detection in EEG Recordings
brainboost GmbH（brainboost有限公司）；Institute for Applied Computer Science, Bundeswehr University Munich（慕尼黑联邦国防军大学应用计算机科学研究所）；Center for Machine Learning, Heilbronn University（海尔布隆大学机器学习中心）
Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；University of Ferrara（费拉拉大学）
Transcranial Magnetic Stimulation (TMS) combined with EEG recordings (TMS-EEG) has shown great potential in the study of the brain and in particular of Alzheimer's Disease (AD). In this study, we propose an automatic method of determining the duration of TMS induced perturbation of the EEG signal as a potential metric reflecting the brain's functional alterations. A preliminary study is conducted in patients with Alzheimer's disease (AD). Three metrics for characterizing the strength and duration of TMS evoked EEG (TEP) activity are proposed and their potential in identifying AD patients from …
BioSensics LLC（BioSensics有限责任公司）；Brown University（布朗大学）；University of Southern California（南加州大学）
Epilepsy is one of the most common neurological disorders, typically observed via seizure episodes. Epileptic seizures are commonly monitored through electroencephalogram (EEG) recordings due to their routine and low expense collection. The stochastic nature of EEG makes seizure identification via manual inspections performed by highly-trained experts a tedious endeavor, motivating the use of automated identification. The literature on automated identification focuses mostly on supervised learning methods requiring expert labels of EEG segments that contain seizures, which are difficult to obt…
