细胞黏附与拓扑结构在形态发生核心的对话
A dialog between cell adhesion and topology at the core of morphogenesis
AI总结：
研究探讨细胞黏附与拓扑结构如何协调组织形态发生，揭示其在胚胎组织拓扑和材料性质中的关键作用。
摘要：
在生物体发育过程中，细胞必须协调和组织以生成正确的组织和器官形状、结构和空间模式，这一过程称为形态发生。胚胎组织的形态发生依赖于多种过程，这些过程诱导出组织所需的精确物理变形，以最终形成具有复杂几何结构的器官。在塑造形态发生路径中最活跃的玩家是精细调节的细胞黏附变化。本文回顾了最近的进展，显示细胞黏附的变化，一种在细胞-细胞接触水平定义的局部、成对性质，对胚胎组织拓扑有重要影响，是定义早期胚胎组织几何和材料性质的关键因素。
英文摘要：
During the development of an organism, cells must coordinate and organize to generate the correct shape, structure, and spatial patterns of tissues and organs, a process known as morphogenesis. The morphogenesis of embryonic tissues is supported by multiple processes that induce the precise physical deformations required for tissues to ultimately form organs with complex geometries. Among the most active players shaping the morphogenetic path are fine-tuned changes in cell adhesion. We review here recent advances showing that changes on cell adhesion, a local, pair-wise property defined at the cell-cell contact level has important global consequences for embryonic tissue topology, being determinant in defining both the geometric and material properties of early embryo tissues.
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