First ex-vivo positronium imaging of tissues with modular J-PET scanner using $^{44}$Sc radionuclide
Jagiellonian University（雅盖隆大学）；AGH University of Science and Technology（AGH科技大学）；Institute of Nuclear Chemistry and Technology（核化学与技术研究所）；University of Warsaw（华沙大学）；Cracow University of Technology（克拉科夫理工大学）；INFN, Laboratori Nazionali di Frascati（意大利国家核物理研究所，弗拉斯卡蒂国家实验室）
Karol Kubat, Manish Das, Sushil Sharma, Ermias Y. Beyene, Aleksander Bilewicz, Jarosław Choiński, Neha Chug, Catalina Curceanu, Eryk Czerwiński, Jakub Hajduga, … 展开作者
Karol Kubat, Manish Das, Sushil Sharma, Ermias Y. Beyene, Aleksander Bilewicz, Jarosław Choiński, Neha Chug, Catalina Curceanu, Eryk Czerwiński, Jakub Hajduga, Sharareh Jalali, Krzysztof Kacprzak, Tevfik Kaplanoglu, Łukasz Kapłon, Kamila Kasperska, Aleksander Khreptak, Grzegorz Korcyl, Tomasz Kozik, Deepak Kumar, Sumit Kumar Kundu, Anoop Kunimmal-Venadan, Bartosz Leszczyński, Edward Lisowski, Filip Lisowski, Justyna Mędrala-Sowa, Simbarashe Moyo, Wiktor Mryka, Szymon Niedźwiecki, Anand Pandey, Piyush Pandey, Szymon Parzych, Alessio Porcelli, Bartłomiej Rachwał, Martin Rädler, Magdalena Skurzok, Anna Stolarz, Tomasz Szumlak, Pooja Tanty, Keyvan Tayefi Ardebili, Satyam Tiwari, Kavya Valsan Eliyan, Rafał Walczak, Paweł Moskal, Ewa Ł. Stępień
备注：
to be published in Zeitschrift für Medizinische Physik
This study presents the first ex-vivo positronium imaging of human tissues using the modular J-PET scanner with the $^{44}$Sc radionuclide. The $^{44}$Sc isotope was produced via the $^{44}$Ca(p, n)$^{44}$Sc nuclear reaction and used to perform positronium imaging of phantom composed of human adipose tissue, cardiac myxoma tissue, thrombi blood clot, and also porous polymer XAD4, and a certified reference material (CRM) made from fused silica. The experiment demonstrates the suitability of $^{44}$Sc as a positron source for positronium imaging. The performance of J-PET for positronium imaging with $^{44}$Sc was validated by proper reconstruction of the mean orthopositronium lifetime for CRM material and XAD-4 polymer. The mean ortho-positronium (oPs) lifetimes determined for adipose tissue, cardiac myxoma tissues and thrombi were consistent with results of previous experiments. The study highlights the potential $^{44}$Sc radionuclide for positronium lifetime imaging (PLI).
In vivo assessment of cancer and precise location of altered tissues at initial stages of molecular disorders are important diagnostic challenges. Positronium is copiously formed in the free molecular spaces in the patient's body during positron emission tomography (PET). The positronium properties vary according to the size of inter- and intramolecular voids and the concentration of molecules in them such as, e.g., molecular oxygen, O2; therefore, positronium imaging may provide information about disease progression during the initial stages of molecular alterations. Current PET systems do no…
A detection system of the conventional PET tomograph is set-up to record data from e+ e- annihilation into two photons with energy of 511 keV, and it gives information on the density distribution of a radiopharmaceutical in the body of the object. In this paper we explore the possibility of performing the three gamma photons imaging based on ortho-positronium annihilation, as well as the possibility of positronium mean lifetime imaging with the J-PET tomograph constructed from plastic scintillators. For this purposes simulations of the ortho-positronium formation and its annihilation into thre…
In living organisms the positron-electron annihilation (occurring during the PET imaging) proceeds in about 30% via creation of a metastable ortho-positronium atom. In the tissue, due to the pick-off and conversion processes, over 98% of ortho-positronia annihilate into two 511~keV photons. In this article we assess the feasibility for reconstruction of the mean ortho-positronium lifetime image based on annihilations into two photons. The main objectives of this work include: (i) estimation of the sensitivity of the total-body PET scanners for the ortho-positronium mean lifetime imaging using …
The Jagiellonian Positron Emission Tomograph (J-PET) is a detector for medical imaging of the whole human body as well as for physics studies involving detection of electron-positron annihilation into photons. J-PET has high angular and time resolution and allows for measurement of spin of the positronium and the momenta and polarization vectors of annihilation quanta. In this article, we present the potential of the J-PET system for background rejection in the decays of positronium atoms.
First Positronium Lifetime Imaging using $^{52}$Mn and $^{55}$Co with a plastic-based PET scanner
Jagiellonian University（雅盖隆大学）；Center for Theranostics, Jagiellonian University（雅盖隆大学诊疗中心）；Doctoral School of Exact and Natural Sciences, Jagiellonian University（雅盖隆大学精确与自然科学学院）；Institute of Nuclear Chemistry and Technology（核化学与技术研究所）；University of Warsaw（华沙大学）；Laboratori Nazionali di Frascati, INFN（INFN弗拉斯卡蒂国家实验室）
Feasibility study of the positronium lifetime imaging with the Biograph Vision Quadra and J-PET tomographs
Jagiellonian University（雅盖隆大学）；Siemens Medical Solutions USA, Inc.（西门子医疗美国公司）；Istituto Nazionale di Fisica Nucleare（意大利国家核物理研究所）；AGH University of Kraków（克拉科夫AGH科技大学）；Cracow University of Technology（克拉科夫理工大学）；Bern University Hospital, University of Bern（伯尔尼大学医院）
Three-Photon Bayesian Imaging of Ortho-Positronium
National Centre for Nuclear Research（国家核研究中心）；INSA-Lyon（里昂国立应用科学学院）；Université Claude Bernard Lyon 1（里昂第一大学（克洛德·贝尔纳大学））；CNRS（法国国家科学研究中心）；Inserm（法国国家健康与医学研究院）；IT:U Interdisciplinary Transformation University（IT:U跨学科转型大学）；University of Vienna（维也纳大学）
Quantum Entanglement Degree, Mean Positronium Lifetime, and the $3γ$/$2γ$ Annihilation-Rate Ratio as Novel PET Biomarkers for Hypoxia -- Concept, Challenges, and Predictions
The purpose of the presented investigations is to design, construct and establish the characteristic performance of the Jagiellonian Positron Emission Mammography(J-PEM), being designed for the detection and diagnosis of breast cancer. Its construction is based on a novel idea of PET tomography based on plastic scintillators and wavelength shifter (WLS) and a new concept of positronium imaging. We have prepared a simulation program based on Monte Carlo methods for optimizing the geometry and material of the J-PEM prototype. Here we present the first results from the simulations and a brief rev…
A Monte Carlo positronium decay source model with multiple annihilation channels in GATE
National Centre for Nuclear Research（国家核研究中心）；Jagiellonian University（雅盖隆大学）；INSA-Lyon, Université Claude Bernard Lyon 1（里昂国立应用科学学院，克劳德·贝尔纳里昂大学）；IT:U Interdisciplinary Transformation University（跨学科转型大学）；University of Vienna（维也纳大学）
Positron Annihilation Lifetime Spectroscopy (PALS) allows examining structure of materials in nano and sub-nanometer scale. This technique is based on the lifetime and intensity of ortho-positronium atoms in free volumes of given structures. It is mostly used for studies in material sciences, but it can also be used for in vivo imaging of the cell morphology as proposed in [1], [2]. Cancer cells are characterized by an altered macro structure in comparison to normal cells, thus the main objective of these studies is to compare if these differences can be detected on sub-nanometer level and the…
A tissue-informed deep learning-based method for positron range correction in preclinical 68Ga PET imaging
University Complutense of Madrid (UCM)（马德里康普顿斯大学）；Instituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSC)（圣卡洛斯临床医院卫生研究所 (IdISSC)）；Memorial Sloan Kettering Cancer Center（纪念斯隆-凯特琳癌症中心）；Weill Cornell Graduate School（韦尔康奈尔研究生院）
Terbium-149 PET/CT: First Quantitative Imaging with a Clinical Long-Axial Field-of-View Scanner
Department of Nuclear Medicine, Inselspital, Bern University Hostpital, University of Bern（伯尔尼大学医院因塞尔斯皮塔尔核医学科）；ARTORG Center for Biomedical Engineering Research, University of Bern（伯尔尼大学ARTORG生物医学工程研究中心）；Albert Einstein Center for Fundamental Physics (AEC), Laboratory for High Energy Physics (LHEP), University of Bern（伯尔尼大学阿尔伯特·爱因斯坦基础物理中心（AEC）高能物理实验室（LHEP））；Center for Radiopharmaceutical Sciences, PSI Center for Life Sciences, Villigen-PSI（维利根-PSI PSI生命科学中心放射药学科学中心）；Institut Laue-Langevin（朗之万研究所）；Laboratory of Radiochemistry, PSI Center for Nuclear Engineering and Sciences（PSI核工程与科学中心放射化学实验室）
Time-Over-Threshold (TOT) technique is being used widely due to its implications in developing the multi channel readouts mainly when fast signal processing is required. Using TOT technique as a measure of energy loss instead of charge integration methods significantly reduces the signals readout cost by combining the time and energy information. Therefore, this approach can potentially be used in J-PET tomograph which is build from plastic scintillators characterized by fast light signals. The drawback in adopting this technique is lying in the non-linear correlation between input energy loss…
