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arXiv 2601.07124cs.LG

向自动诊断遗传性心律失常:结合领域能量注意网络的联合心律失常分类

Towards Automated Diagnosis of Inherited Arrhythmias: Combined Arrhythmia Classification Using Lead-Aware Spatial Attention Networks

University of Alberta(阿尔伯塔大学);University of British Columbia(不列颠哥伦比亚大学);Montreal Heart Institute(蒙特利尔心脏研究所);London Health Sciences Center(伦敦健康科学中心);Quebec Heart and Lung Institute(魁北克心肺研究所);Children’s Heart Centre(儿童心脏中心);University of Toronto(多伦多大学);Sunnybrook Health Sciences Centre(桑尼布鲁克健康科学中心)
Sophie Sigfstead, River Jiang, Brianna Davies, Zachary W. M. Laksman, Julia Cadrin-Tourigny, Rafik Tadros, Habib Khan, Joseph Atallah, Christian Steinberg, Shub… 展开作者

Sophie Sigfstead, River Jiang, Brianna Davies, Zachary W. M. Laksman, Julia Cadrin-Tourigny, Rafik Tadros, Habib Khan, Joseph Atallah, Christian Steinberg, Shubhayan Sanatani, Mario Talajic, Rahul Krishnan, Andrew D. Krahn, Christopher C. Cheung

AI总结:

本研究提出领域能量注意网络(LASAN)用于多类和二分类遗传性心律失常分类,实现了接近天花板的性能,优于现有模型。

摘要:

遗传性心律失常综合征,如右心室心肌病(ARVC)和长QT综合征(LQTS),与突发心脏骤停有关。深度学习在心电图解读中显示出潜力,但多类遗传性心律失常分类在临床上有意义的可解释性仍不完善。我们的目标是开发并验证一种领域能量注意网络(LASAN)的深度学习框架,用于多类(ARVC vs LQTS vs 控制)和二分类遗传性心律失常分类,并确定在心律失常筛查工具中整合ECG基础模型的最佳策略。我们组建了一个13个中心的加拿大队列(645名患者;1,344张ECG)。我们使用三种迁移学习方法评估了四个ECG基础模型:线性探测、微调和结合策略。我们开发了领域能量注意网络(LASAN)并评估了将其与基础模型结合的整合策略。性能与已建立的基础模型基线进行了比较。领域能量掩码量化了疾病特异性领域能量依赖性。微调在所有基础模型中均优于线性探测和结合策略(平均宏AUROC 0.904 vs 0.825)。最佳领域能量整合策略实现了接近天花板性能(HuBERT-ECG混合:宏AUROC 0.990;ARVC vs 控制AUROC 0.999;LQTS vs 控制AUROC 0.994)。领域能量掩码显示了生理学合理性:V1-V3对ARVC检测最为关键(AUROC减少4.54%),而侧向导联对LQTS优先重要(2.60%下降)。领域能量架构在遗传性心律失常分类中实现了最先进的性能,优于所有已发表的模型,在二分类和多分类任务中均表现优异,同时展示了临床一致的领域能量依赖性。这些发现支持了自动ECG筛查的潜在应用,待验证。

英文摘要:

Arrhythmogenic right ventricular cardiomyopathy (ARVC) and long QT syndrome (LQTS) are inherited arrhythmia syndromes associated with sudden cardiac death. Deep learning shows promise for ECG interpretation, but multi-class inherited arrhythmia classification with clinically grounded interpretability remains underdeveloped. Our objective was to develop and validate a lead-aware deep learning framework for multi-class (ARVC vs LQTS vs control) and binary inherited arrhythmia classification, and to determine optimal strategies for integrating ECG foundation models within arrhythmia screening tools. We assembled a 13-center Canadian cohort (645 patients; 1,344 ECGs). We evaluated four ECG foundation models using three transfer learning approaches: linear probing, fine-tuning, and combined strategies. We developed lead-aware spatial attention networks (LASAN) and assessed integration strategies combining LASAN with foundation models. Performance was compared against the established foundation model baselines. Lead-group masking quantified disease-specific lead dependence. Fine-tuning outperformed linear probing and combined strategies across all foundation models (mean macro-AUROC 0.904 vs 0.825). The best lead-aware integrations achieved near-ceiling performance (HuBERT-ECG hybrid: macro-AUROC 0.990; ARVC vs control AUROC 0.999; LQTS vs control AUROC 0.994). Lead masking demonstrated physiologic plausibility: V1-V3 were most critical for ARVC detection (4.54% AUROC reduction), while lateral leads were preferentially important for LQTS (2.60% drop). Lead-aware architectures achieved state-of-the-art performance for inherited arrhythmia classification, outperforming all existing published models on both binary and multi-class tasks while demonstrating clinically aligned lead dependence. These findings support potential utility for automated ECG screening pending validation.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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