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arXiv 2601.03069stat.ME
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一种非参数方法用于估计log-rank检验统计量之间的相关性及其在联合功率计算中的应用

A non-parametric approach for estimating the correlation between log-rank test statistics with applications to a conjunctive power calculation

Anne Lyngholm Soerensen, Paul Blanche, Henrik Ravn, Christian Pipper

AI总结:

本文提出一种非参数方法估计log-rank检验统计量相关性,用于联合功率计算,通过模拟验证方法的可靠性及删失影响。

摘要:

我们提出了一种方法,用于估计评估两个时间到事件终点各自原假设的log-rank检验统计量之间的相关性。该相关性通过个体层面的数据,采用基于独立同分布(iid)分解的非参数方法进行估计,该分解在任何替代假设下都适用于log-rank检验统计量。利用iid分解,我们能够做出假设较少的相关性估计。这里,我们提供了一个使用所开发方法的示例。我们说明了所建议的方法如何用于提供现实的联合功率量化,以指导使用历史数据设计新的随机临床试验。最后,我们通过模拟研究调查了该方法的有限样本性质,该研究确认了所提出方法的无偏和一致行为。此外,模拟研究还揭示了删失对log-rank检验统计量之间相关性的影响。

英文摘要:

We present a method for estimating the correlation between log-rank test statistics evaluating separate null hypotheses for two time-to-event endpoints. The correlation is estimated using subject-level data by a non-parametric approach based on the independent and identically distributed (iid) decomposition of the log-rank test statistic under any alternative. Using the iid decomposition, we are able to make an assumption-lean estimation of the correlation. A motivating example using the developed approach is provided. Here, we illustrate how the suggested approach can be used to give a realistic quantification of expected conjunctive power that can guide the design of a new randomized clinical trial using historical data. Finally, we investigate the method's finite sample properties via a simulation study that confirms unbiased and consistent behavior of the proposed approach. In addition, the simulation study gives insight into the effects of censoring on the correlation between the log-rank test statistics.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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