arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2209.05413stat.ME
收藏

交叉设计中重复测量的半参数广义估计方程

Semi-parametric generalized estimating equations for repeated measurements in cross-over designs

N. A. Cruz, O. O. Melo, C. A. Martinez

摘要:

开发了在每个时期内重复测量的交叉设计模型。它是使用广义估计方程的扩展获得的,广义估计方程包括用于对处理效应进行建模的参数分量和用于对时间和残留效应进行建模的非参数分量;非参数分量的估计方法基于样条。进行了模拟研究,探索模型的属性。因此,当存在结转效应或功能性时间效应时,所提出的模型比标准模型呈现出更好的结果。其中的理论性质,解决方案被发现是类似于加权最小二乘。因此,可以进行模型诊断,以适应多元回归的结果。所提出的方法在交叉实验的数据集中实施,这些实验激发了这项工作的方法:兔子的收缩压和胰岛素。

英文摘要:

A model for cross-over designs with repeated measures within each period was developed. It is obtained using an extension of generalized estimating equations that includes a parametric component to model treatment effects and a non-parametric component to model time and carry-over effects; the estimation approach for the non-parametric component is based on splines. A simulation study was carried out to explore the model properties. Thus, when there is a carry-over effect or a functional temporal effect, the proposed model presents better results than the standard models. Among the theoretical properties, the solution is found to be analogous to weighted least squares. Therefore, model diagnostics can be made adapting the results from a multiple regression. The proposed methodology was implemented in the data sets of the crossover experiments that motivated the approach of this work: systolic blood pressure and insulin in rabbits.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

↑