超高速场临床前高分辨率和3D 1H-MRSI的优化与应用
Optimization and application of ultra-high field preclinical high-resolution and 3D 1H-MRSI using compressed sensing
AI总结：
本研究利用压缩感知技术优化超高速场临床前3D 1H-MRSI，实现高分辨率和多切片采集，缩短采集时间至30分钟以内。
摘要：
质子磁共振波谱成像（1H-MRSI）在超高速场中已被广泛应用于临床前领域。与长采集时间和小鼠大脑中代谢物浓度低相关的挑战，导致了3D-1H-MRSI加速方案的发展和应用，例如压缩感知（CS）的欠采样技术。本研究旨在探索CS工具在临床前体内应用中的潜力，以实现2D高分辨率MRSI采集，包括平面内增加和3D/多切片采集。参数研究显示，通过选择k空间中心核心的合适采样大小，可以实现加速因子（AF）为4的采集。使用这种特定设置，通过2D-FID-MRSI获得更高矩阵大小，从而得到小于1μL的名义体素大小，并通过添加9个补充相位编码/切片来实现3D-FID-MRSI。与非加速的2D-FID-MRSI相比，光谱质量和代谢图在感兴趣切片内足够准确。在CS的不同使用中，注意到点扩散函数（PSF）相关的问题。我们的工作提出了一种稳健且有效的协议，利用CS实现3D-1H-MRSI，以达到低于30分钟的采集时间，同时具有最小的技术限制和高质量的采集。
英文摘要：
Proton magnetic resonance spectroscopic imaging (1H-MRSI) at ultra-high field has seen an increase in usage in the preclinical field. Challenges related to long acquisition time and low concentration of brain metabolites in the rodent brain have led to the development and application of acceleration schemes for 3D-1H-MRSI, such the undersampling technique Compressed Sensing (CS). This present study aims to explore the CS tool in the context of preclinical in vivo application in order to achieve high-resolution MRSI acquisition in both 2D with an in-plane increase and 3D/multi-slice acquisition with through-plane. The parameters are explored to achieve the highest acceleration possible as a way to make 3D as time efficient as possible. Results of the parameter study showed that an acceleration factor (AF) of 4 was possible with the right sampling size of the core at the center of the k-space. With this specific set, higher matrix size resulting in sub 1 μL nominal voxel size was explored with 2D-FID-MRSI and 9 supplementary phase-encoding/slices were added to achieve 3D-FID-MRSI. The spectral quality and the metabolic maps were accurate enough in the comparison with the non-accelerated 2D-FID-MRSI, within the slice of interest. Issues related with the point spread function (PSF) were noted throughout the different usage of CS. Our work presents a robust and effective protocol to achieve 3D-1H-MRSI using CS in order to reach an acquisition time below the 30 minutes bar, with minimal technical limitations and high-quality acquisition.
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