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arXiv 2505.04653cs.CLcs.AIcs.CVcs.LG

利用多模态推理推进对话式诊断人工智能

Advancing Conversational Diagnostic AI with Multimodal Reasoning

Google(谷歌);DeepMind(深Mind);Google Research(谷歌研究院)
Khaled Saab, Jan Freyberg, Chunjong Park, Tim Strother, Yong Cheng, Wei-Hung Weng, David G. T. Barrett, David Stutz, Nenad Tomasev, Anil Palepu, Valentin Liévin… 展开作者

Khaled Saab, Jan Freyberg, Chunjong Park, Tim Strother, Yong Cheng, Wei-Hung Weng, David G. T. Barrett, David Stutz, Nenad Tomasev, Anil Palepu, Valentin Liévin, Yash Sharma, Roma Ruparel, Abdullah Ahmed, Elahe Vedadi, Kimberly Kanada, Cian Hughes, Yun Liu, Geoff Brown, Yang Gao, Sean Li, S. Sara Mahdavi, James Manyika, Katherine Chou, Yossi Matias, Avinatan Hassidim, Dale R. Webster, Pushmeet Kohli, S. M. Ali Eslami, Joëlle Barral, Adam Rodman, Vivek Natarajan, Mike Schaekermann, Tao Tu, Alan Karthikesalingam, Ryutaro Tanno

AI总结:

本文提出基于 Gemini 2.0 Flash 的状态感知对话框架,使 AMIE 能在诊断对话中收集、解读并推理多模态医学资料,并在随机盲法 OSCE 式研究中于多数多模态及非多模态维度上优于初级保健医生。

摘要:

大型语言模型(LLMs)在开展诊断对话方面已展现出巨大潜力,但对其评估在很大程度上仍局限于仅使用语言的交互,这偏离了远程医疗服务在真实世界中的要求。即时通讯平台允许临床医生和患者在医疗咨询中无缝上传并讨论多模态医学资料,但LLMs在对此类数据进行推理的同时,能否保持胜任诊断对话所需的其他属性,目前仍不清楚。在此,我们通过一种新的能力来推进 Articulate Medical Intelligence Explorer(AMIE)的对话式诊断与管理性能,该能力能够收集和解读多模态数据,并在咨询过程中对其进行精确推理。借助 Gemini 2.0 Flash,我们的系统实现了一个状态感知的对话框架,其中对话流程由反映患者状态和不断演变的诊断的中间模型输出动态控制。后续追问由这些患者状态中的不确定性进行策略性引导,从而形成一种更具结构性的多模态病史采集过程,模拟经验丰富的临床医生的做法。我们在一项随机、盲法、OSCE 风格、基于聊天咨询且由患者演员参与的研究中,将 AMIE 与初级保健医生(PCPs)进行了比较。我们利用智能手机皮肤照片、心电图(ECGs)和临床文档 PDF 等资料,构建了涵盖不同疾病和人口统计学特征的 105 个评估场景。我们的评分标准评估了多模态能力以及其他具有临床意义的维度,如病史采集、诊断准确性、管理推理、沟通和同理心。专科医生评估显示,AMIE 在 7/9 个多模态维度和 29/32 个非多模态维度(包括诊断准确性)上优于 PCPs。结果表明,多模态对话式诊断人工智能取得了明显进展,但向真实世界的转化仍需进一步研究。

英文摘要:

Large Language Models (LLMs) have demonstrated great potential for conducting diagnostic conversations but evaluation has been largely limited to language-only interactions, deviating from the real-world requirements of remote care delivery. Instant messaging platforms permit clinicians and patients to upload and discuss multimodal medical artifacts seamlessly in medical consultation, but the ability of LLMs to reason over such data while preserving other attributes of competent diagnostic conversation remains unknown. Here we advance the conversational diagnosis and management performance of the Articulate Medical Intelligence Explorer (AMIE) through a new capability to gather and interpret multimodal data, and reason about this precisely during consultations. Leveraging Gemini 2.0 Flash, our system implements a state-aware dialogue framework, where conversation flow is dynamically controlled by intermediate model outputs reflecting patient states and evolving diagnoses. Follow-up questions are strategically directed by uncertainty in such patient states, leading to a more structured multimodal history-taking process that emulates experienced clinicians. We compared AMIE to primary care physicians (PCPs) in a randomized, blinded, OSCE-style study of chat-based consultations with patient actors. We constructed 105 evaluation scenarios using artifacts like smartphone skin photos, ECGs, and PDFs of clinical documents across diverse conditions and demographics. Our rubric assessed multimodal capabilities and other clinically meaningful axes like history-taking, diagnostic accuracy, management reasoning, communication, and empathy. Specialist evaluation showed AMIE to be superior to PCPs on 7/9 multimodal and 29/32 non-multimodal axes (including diagnostic accuracy). The results show clear progress in multimodal conversational diagnostic AI, but real-world translation needs further research.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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