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arXiv 2504.02488q-bio.PEphysics.soc-ph
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行为与疾病测试与隔离模型

A Behaviour and Disease Model of Testing and Isolation

Commonwealth Scientific and Industrial Research Organisation (CSIRO)(联邦科学与工业研究组织);James Cook University(詹姆斯库克大学);Civic Health Innovation Labs(公民健康创新实验室);Institute of Population Health(人口健康研究所);NIHR Health Protection Research Unit in Emerging and Zoonotic Infections(英国国家卫生研究院新兴与动物源性感染卫生保护研究组);University of Liverpool(利物浦大学);Department of Mathematics, University of Manchester(曼彻斯特大学数学系);Department of Statistical Science, University College London(伦敦大学学院统计科学系);Department of Health, Medicine and Caring Sciences, Linköping University(林雪平大学健康、医学与护理科学学院);New Zealand Institute for Advanced Study, Massey University(梅西大学新西兰高级研究院)

Matthew Ryan, Roslyn I. Hickson, Edward M. Hill, Thomas House, Valerie Isham, Dongni Zhang, Mick G. Roberts

AI总结:

本文提出一个结合行为与疾病动力学的模型,研究测试和隔离决策对传染病传播的影响,并分析其基本再生数和流行病持续性。

摘要:

在数学流行病学历史上,关于传染病动力学与行为相互作用的兴趣一直存在。这包括考虑哪些数学模型最能捕捉每种现象以及它们的相互作用,但通常是以对所讨论的具体行为无差别的方式进行。在这里,我们具体研究与测试和隔离决策相关的相互作用行为和疾病动力学。为了进行我们的研究,我们扩展了一个现有的

英文摘要:

There has been interest in the interactions between infectious disease dynamics and behaviour for most of the history of mathematical epidemiology. This has included consideration of which mathematical models best capture each phenomenon, as well as their interaction, but typically in a manner that is agnostic to the exact behaviour in question. Here, we investigate interacting behaviour and disease dynamics specifically related to decisions around testing and isolation. To carry out our investigation we extend an existing "behaviour and disease" (BaD) model by incorporating the dynamics of symptomatic testing and isolation, including the influence of positive tests on perception of infection risk. We provide a dynamical systems analysis of the ordinary differential equations that define this model, providing theoretical results on its behaviour early in a new outbreak (particularly its basic reproduction number) and endemicity of the system (its steady states and associated stability criteria). We then supplement these findings with a numerical analysis to inform how temporal and cumulative outbreak metrics depend on the model parameter values for epidemic and endemic regimes. We observe novel model outputs such as epidemics that have more observed cases detected through increased testing, but are less objectively severe in terms of total number of infections.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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