Medical image denoising is essential for improving the reliability of clinical diagnosis and guiding subsequent image-based tasks. In this paper, we propose a multi-scale approach that integrates anisotropic Gaussian filtering with progressive Bezier-path redrawing. Our method constructs a scale-space pyramid to mitigate noise while preserving critical structural details. Starting at the coarsest scale, we segment partially denoised images into coherent components and redraw each using a parametric Bezier path with representative color. Through iterative refinements at finer scales, small and intricate structures are accurately reconstructed, while large homogeneous regions remain robustly smoothed. We employ both mean square error and self-intersection constraints to maintain shape coherence during path optimization. Empirical results on multiple MRI datasets demonstrate consistent improvements in PSNR and SSIM over competing methods. This coarse-to-fine framework offers a robust, data-efficient solution for cross-domain denoising, reinforcing its potential clinical utility and versatility. Future work extends this technique to three-dimensional data.
Confocal microscopy is essential for histopathologic cell visualization and quantification. Despite its significant role in biology, fluorescence confocal microscopy suffers from the presence of inherent noise during image acquisition. Non-local patch-wise Bayesian mean filtering (NLB) was until recently the state-of-the-art denoising approach. However, classic denoising methods have been outperformed by neural networks in recent years. In this work, we propose to exploit the strengths of NLB in the framework of Bayesian deep learning. We do so by designing a convolutional neural network and t…
Classic algebraic reconstruction technology (ART) for computed tomography requires pre-determined weights of the voxels for projecting pixel values. However, such weight cannot be accurately obtained due to the limitation of the physical understanding and computation resources. In this study, we propose a semi-case-wise learning-based method named Weight Encode Reconstruction Network (WERNet) to tackle the issues mentioned above. The model is trained in a self-supervised manner without the label of a voxel set. It contains two branches, including the voxel weight encoder and the voxel attentio…
Fudan University（复旦大学）；Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University（复旦大学类脑智能科学与技术研究院）；Huashan Hospital, Fudan University（复旦大学附属华山医院）
Small lesions in magnetic resonance imaging (MRI) images are crucial for clinical diagnosis of many kinds of diseases. However, the MRI quality can be easily degraded by various noise, which can greatly affect the accuracy of diagnosis of small lesion. Although some methods for denoising MR images have been proposed, task-specific denoising methods for improving the diagnosis confidence of small lesions are lacking. In this work, we propose a voxel-wise hybrid residual MLP-CNN model to denoise three-dimensional (3D) MR images with small lesions. We combine basic deep learning architecture, MLP…
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院（KAIST））；VUNO Corp.（VUNO公司）；Chungnam National University College of Medicine（忠南大学医学院）；Chungnam National University Hospital（忠南大学医院）
The acquisition conditions for low-dose and high-dose CT images are usually different, so that the shifts in the CT numbers often occur. Accordingly, unsupervised deep learning-based approaches, which learn the target image distribution, often introduce CT number distortions and result in detrimental effects in diagnostic performance. To address this, here we propose a novel unsupervised learning approach for lowdose CT reconstruction using patch-wise deep metric learning. The key idea is to learn embedding space by pulling the positive pairs of image patches which shares the same anatomical s…
University Medical Center Mannheim, Heidelberg University（海德堡大学曼海姆医学中心）
Poisson noise suppression is an important preprocessing step in several applications, such as medical imaging, microscopy, and astronomical imaging. In this work, we propose a novel patch-wise Poisson noise removal strategy, in which the MMSE estimator is utilized in order to produce the denoising result for each image patch. Fast and accurate computation of the MMSE estimator is carried out using k-d tree search followed by search in the K-nearest neighbor graph. Our experiments show that the proposed method is the preferable choice for low signal-to-noise ratios.
Deep neural networks have been widely used in image denoising during the past few years. Even though they achieve great success on this problem, they are computationally inefficient which makes them inappropriate to be implemented in mobile devices. In this paper, we propose an efficient deep neural network for image denoising based on pixel-wise classification. Despite using a computationally efficient network cannot effectively remove the noises from any content, it is still capable to denoise from a specific type of pattern or texture. The proposed method follows such a divide and conquer s…
For flexible non-blind image denoising, existing deep networks usually take both noisy image and noise level map as the input to handle various noise levels with a single model. However, in this kind of solution, the noise variance (i.e., noise level) is only deployed to modulate the first layer of convolution feature with channel-wise shifting, which is limited in balancing noise removal and detail preservation. In this paper, we present a novel flexible image enoising network (CFMNet) by equipping an U-Net backbone with multi-layer conditional feature modulation (CFM) modules. In comparison …
Video Denoising is one of the fundamental tasks of any videoprocessing pipeline. It is different from image denoising due to the tem-poral aspects of video frames, and any image denoising approach appliedto videos will result in flickering. The proposed method makes use oftemporal as well as spatial dimensions of video frames as part of a two-stage pipeline. Each stage in the architecture named as Spatio-TemporalNetwork uses a channel-wise attention mechanism to forward the encodersignal to the decoder side. The Attention Block used in this paper usessoft attention to ranks the filters for bet…
Qingdao University（青岛大学）；Harbin Institute of Technology（哈尔滨工业大学）；University of Electronic Science and Technology of China（电子科技大学）；University of Kentucky（肯塔基大学）；University of California, Santa Barbara（加州大学圣巴巴拉分校）
In this paper, we propose a novel nonconvex approach to robust principal component analysis for HSI denoising, which focuses on simultaneously developing more accurate approximations to both rank and column-wise sparsity for the low-rank and sparse components, respectively. In particular, the new method adopts the log-determinant rank approximation and a novel $\ell_{2,\log}$ norm, to restrict the local low-rank or column-wisely sparse properties for the component matrices, respectively. For the $\ell_{2,\log}$-regularized shrinkage problem, we develop an efficient, closed-form solution, which…
Spach Transformer: Spatial and Channel-wise Transformer Based on Local and Global Self-attentions for PET Image Denoising
Gordon Center for Medical Imaging（戈登医学影像中心）；Center for Advanced Medical Computing and Analysis（高级医学计算与分析中心）；Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；University of Florida（佛罗里达大学）；University of Texas MD Anderson Cancer Center（德克萨斯大学MD安德森癌症中心）；Johns Hopkins University（约翰斯·霍普金斯大学）
针对 PET 图像噪声及三维全局自注意力计算成本高的问题，提出融合局部与全局 MSA 的空间通道编解码 Transformer，并在多示踪剂数据集上验证其去噪性能优于现有深度学习架构。
Qingdao University（青岛大学）；Harbin Institute of Technology（哈尔滨工业大学）；University of Kentucky（肯塔基大学）
It is a challenging task to remove heavy and mixed types of noise from Hyperspectral images (HSIs). In this paper, we propose a novel nonconvex approach to RPCA for HSI denoising, which adopts the log-determinant rank approximation and a novel $\ell_{2,\log}$ norm, to restrict the low-rank or column-wise sparse properties for the component matrices, respectively.For the $\ell_{2,\log}$-regularized shrinkage problem, we develop an efficient, closed-form solution, which is named $\ell_{2,\log}$-shrinkage operator, which can be generally used in other problems. Extensive experiments on both simul…
Harbin Institute of Technology（哈尔滨工业大学）；Megvii Inc（旷视科技有限公司）
Recently, deep learning-based image denoising methods have achieved promising performance on test data with the same distribution as training set, where various denoising models based on synthetic or collected real-world training data have been learned. However, when handling real-world noisy images, the denoising performance is still limited. In this paper, we propose a simple yet effective Bayesian deep ensemble (BDE) method for real-world image denoising, where several representative deep denoisers pre-trained with various training data settings can be fused to improve robustness. The found…
Wuhan University（武汉大学）；University of Arkansas（阿肯色大学）；Wuhan Institute of Technology（武汉工程大学）
Hyperspectral images (HSIs) have been widely used in a variety of applications thanks to the rich spectral information they are able to provide. Among all HSI processing tasks, HSI denoising is a crucial step. Recently, deep learning-based image denoising methods have made great progress and achieved great performance. However, existing methods tend to ignore the correlations between adjacent spectral bands, leading to problems such as spectral distortion and blurred edges in denoised results. In this study, we propose a novel HSI denoising network, termed SSCAN, that combines group convolutio…
Jiangxi University of Finance and Economics（江西财经大学）；Chinese Academy of Sciences（中国科学院）
A mainstream type of the state of the arts (SOTAs) based on convolutional neural network (CNN) for real image denoising contains two sub-problems, i.e., noise estimation and non-blind denoising. This paper considers real noise approximated by heteroscedastic Gaussian/Poisson Gaussian distributions with in-camera signal processing pipelines. The related works always exploit the estimated noise prior via channel-wise concatenation followed by a convolutional layer with spatially sharing kernels. Due to the variable modes of noise strength and frequency details of all feature positions, this desi…
Blind-spot network (BSN) and its variants have made significant advances in self-supervised denoising. Nevertheless, they are still bound to synthetic noisy inputs due to less practical assumptions like pixel-wise independent noise. Hence, it is challenging to deal with spatially correlated real-world noise using self-supervised BSN. Recently, pixel-shuffle downsampling (PD) has been proposed to remove the spatial correlation of real-world noise. However, it is not trivial to integrate PD and BSN directly, which prevents the fully self-supervised denoising model on real-world images. We propos…
University of Texas Southwestern Medical Centre（德克萨斯大学西南医学中心）
Despite the indispensable role of X-ray computed tomography (CT) in diagnostic medicine field, the associated ionizing radiation is still a major concern considering that it may cause genetic and cancerous diseases. Decreasing the exposure can reduce the dose and hence the radiation-related risk, but will also induce higher quantum noise. Supervised deep learning can be used to train a neural network to denoise the low-dose CT (LDCT). However, its success requires massive pixel-wise paired LDCT and normal-dose CT (NDCT) images, which are rarely available in real practice. To alleviate this pro…
School of Mathematics, Sichuan University（四川大学数学学院）
Deep learning based methods have achieved the state-of-the-art performance in image denoising. In this paper, a deep learning based denoising method is proposed and a module called fusion block is introduced in the convolutional neural network. For this so-called Noise Fusion Convolutional Neural Network (NFCNN), there are two branches in its multi-stage architecture. One branch aims to predict the latent clean image, while the other one predicts the residual image. A fusion block is contained between every two stages by taking the predicted clean image and the predicted residual image as a pa…
Neural Architecture Search (NAS) for automatically finding the optimal network architecture has shown some success with competitive performances in various computer vision tasks. However, NAS in general requires a tremendous amount of computations. Thus reducing computational cost has emerged as an important issue. Most of the attempts so far has been based on manual approaches, and often the architectures developed from such efforts dwell in the balance of the network optimality and the search cost. Additionally, recent NAS methods for image restoration generally do not consider dynamic opera…
A problem of image denoising when images are corrupted by a non-stationary noise is considered in this paper. Since in practice no a priori information on noise is available, noise statistics should be pre-estimated for image denoising. In this paper, deep convolutional neural network (CNN) based method for estimation of a map of local, patch-wise, standard deviations of noise (so-called sigma-map) is proposed. It achieves the state-of-the-art performance in accuracy of estimation of sigma-map for the case of non-stationary noise, as well as estimation of noise variance for the case of additiv…
With the advent of advances in self-supervised learning, paired clean-noisy data are no longer required in deep learning-based image denoising. However, existing blind denoising methods still require the assumption with regard to noise characteristics, such as zero-mean noise distribution and pixel-wise noise-signal independence; this hinders wide adaptation of the method in the medical domain. On the other hand, unpaired learning can overcome limitations related to the assumption on noise characteristics, which makes it more feasible for collecting the training data in real-world scenarios. I…
University of Chinese Academy of Sciences（中国科学院大学）；Research Center on Fictitious Economy and Data Science, Chinese Academy of Sciences（中国科学院虚拟经济与数据科学研究中心）；Key Laboratory of Big Data Mining and Knowledge Management Chinese Academy of Sciences（中国科学院大数据挖掘与知识管理重点实验室）
In this paper, we present a general framework for low-level vision tasks including image compression artifacts reduction and image denoising. Under this framework, a novel concatenated attention neural network (CANet) is specifically designed for image restoration. The main contributions of this paper are as follows: First, by applying concise but effective concatenation and feature selection mechanism, we establish a novel connection mechanism which connect different modules in the modules stacking network. Second, both pixel-wise and channel-wise attention mechanisms are used in each module …
City University of Hong Kong（香港城市大学）；SenseTime Research（商汤科技研究院）
We investigate the generalization of semi-supervised learning (SSL) to diverse pixel-wise tasks. Although SSL methods have achieved impressive results in image classification, the performances of applying them to pixel-wise tasks are unsatisfactory due to their need for dense outputs. In addition, existing pixel-wise SSL approaches are only suitable for certain tasks as they usually require to use task-specific properties. In this paper, we present a new SSL framework, named Guided Collaborative Training (GCT), for pixel-wise tasks, with two main technical contributions. First, GCT addresses t…
Nanjing Forestry University（南京林业大学）；University of Michigan（密歇根大学）；FXPAL inc.（FX帕洛阿尔托实验室公司）；Zhejiang A&F University（浙江农林大学）；University of Calgary（卡尔加里大学）；Chinese Academy of Sciences（中国科学院）；University of Chinese Academy of Sciences（中国科学院大学）；FX Palo Alto Laboratory Inc.（FX帕洛阿尔托实验室公司）
Sliding-window based low-rank matrix approximation (LRMA) is a technique widely used in hyperspectral images (HSIs) denoising or completion. However, the uncertainty quantification of the restored HSI has not been addressed to date. Accurate uncertainty quantification of the denoised HSI facilitates to applications such as multi-source or multi-scale data fusion, data assimilation, and product uncertainty quantification, since these applications require an accurate approach to describe the statistical distributions of the input data. Therefore, we propose a prior-free closed-form element-wise …
The explosive rise of the use of Computer tomography (CT) imaging in medical practice has heightened public concern over the patient's associated radiation dose. However, reducing the radiation dose leads to increased noise and artifacts, which adversely degrades the scan's interpretability. Consequently, an advanced image reconstruction algorithm to improve the diagnostic performance of low dose ct arose as the primary concern among the researchers, which is challenging due to the ill-posedness of the problem. In recent times, the deep learning-based technique has emerged as a dominant method…
Decomposition of digital signals and images into other basis or dictionaries than time or space domains is a very common approach in signal and image processing and analysis. Such a decomposition is commonly obtained using fixed transforms (e.g., Fourier or wavelet) or dictionaries learned from example databases or from the signal or image itself. In this work, we investigate in detail a new approach of constructing such a signal or image-dependent bases inspired by quantum mechanics tools, i.e., by considering the signal or image as a potential in the discretized Schroedinger equation. To ill…
Centrum Wiskunde & Informatica（荷兰国家数学与计算机科学研究中心）；Leiden Institute of Advanced Computer Science, Leiden Universiteit（莱顿大学高级计算机科学研究所）
Recovering a high-quality image from noisy indirect measurements is an important problem with many applications. For such inverse problems, supervised deep convolutional neural network (CNN)-based denoising methods have shown strong results, but the success of these supervised methods critically depends on the availability of a high-quality training dataset of similar measurements. For image denoising, methods are available that enable training without a separate training dataset by assuming that the noise in two different pixels is uncorrelated. However, this assumption does not hold for inve…
Learning a Model-Driven Variational Network for Deformable Image Registration
University of Birmingham（伯明翰大学）；Alan Turing Institute（阿兰·图灵研究所）；Shenzhen University（深圳大学）；Imperial College London（伦敦帝国学院）；MRC London Institute of Medical Sciences（英国医学研究理事会伦敦医学科学研究所）
Nanyang Technological University（南洋理工大学）；University of Illinois, Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）
Image prior modeling is the key issue in image recovery, computational imaging, compresses sensing, and other inverse problems. Recent algorithms combining multiple effective priors such as the sparse or low-rank models, have demonstrated superior performance in various applications. However, the relationships among the popular image models are unclear, and no theory in general is available to demonstrate their connections. In this paper, we present a theoretical analysis on the image models, to bridge the gap between applications and image prior understanding, including sparsity, group-wise s…
