arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2409.17751stat.MEstat.APstat.CO
收藏

混合时间序列广义线性模型的Granger因果性:多模态脑连接性的案例研究

Granger Causality for Mixed Time Series Generalized Linear Models: A Case Study on Multimodal Brain Connectivity

Luiza S. C. Piancastelli, Wagner Barreto-Souza, Norbert J. Fortin, Keiland W. Cooper, Hernando Ombao

AI总结:

本文提出一种基于混合时间序列广义线性模型的贝叶斯框架,用于评估多模态脑连接数据中的Granger因果性,揭示了LFP beta频段功率对300毫秒后大鼠脉冲活动的预测作用。

摘要:

本文的研究动机源于神经科学实验,旨在利用捕获大脑活动不同侧面的不同类型数据模态,理解大脑网络中节点间的相互作用。为了评估Granger因果性,我们通过一类通用模型引入了灵活的框架,该模型以广义线性模型(GLM)形式容纳混合类型的数据(二值、计数、连续和正成分)。因果性的统计推断基于频率派和贝叶斯方法进行,重点关注后者。在此,我们开发了一种通过所提出的贝叶斯混合时间序列模型进行推断的程序。通过为模型中的某些参数引入spike and slab先验,我们的推断方法指导了因果阶选择,并提供了适当的不确定性量化。随后,所提出的方法被用于研究在嗅觉工作记忆任务期间记录的大鼠脉冲序列和局部场电位(LFP)数据。该方法论为大鼠脉冲活动与LFP频谱功率之间的因果关系提供了关键见解。具体而言,LFP beta频段的功率可以预测300毫秒后的脉冲活动,为神经科学这一新兴关注领域提供了一种新颖的分析工具,并展示了其在一般因果性研究中的实用性和灵活性。

英文摘要:

This paper is motivated by studies in neuroscience experiments to understand interactions between nodes in a brain network using different types of data modalities that capture different distinct facets of brain activity. To assess Granger-causality, we introduce a flexible framework through a general class of models that accommodates mixed types of data (binary, count, continuous, and positive components) formulated in a generalized linear model (GLM) fashion. Statistical inference for causality is performed based on both frequentist and Bayesian approaches, with a focus on the latter. Here, we develop a procedure for conducting inference through the proposed Bayesian mixed time series model. By introducing spike and slab priors for some parameters in the model, our inferential approach guides causality order selection and provides proper uncertainty quantification. The proposed methods are then utilized to study the rat spike train and local field potentials (LFP) data recorded during the olfaction working memory task. The proposed methodology provides critical insights into the causal relationship between the rat spiking activity and LFP spectral power. Specifically, power in the LFP beta band is predictive of spiking activity 300 milliseconds later, providing a novel analytical tool for this area of emerging interest in neuroscience and demonstrating its usefulness and flexibility in the study of causality in general.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

↑