Exploring Foundation Models for Synthetic Medical Imaging: A Study on Chest X-Rays and Fine-Tuning Techniques
Pontifical Catholic University of Rio Grande do Sul (PUCRS)（南里奥格兰德天主教大学（PUCRS））
Davide Clode da Silva, Marina Musse Bernardes, Nathalia Giacomini Ceretta, Gabriel Vaz de Souza, Gabriel Fonseca Silva, Rafael Heitor Bordini, Soraia Raupp Musse
本研究针对医疗数据隐私限制，探索并微调基于预训练基础模型的 Latent Diffusion Model，以生成逼真胸部 X 光片，并由医学专业人员评估不同配置的图像真实感。
摘要：
机器学习通过辅助疾病预防和治疗方案识别，显著推动了医疗保健发展。然而，由于隐私问题和严格法规，获取患者数据可能具有挑战性。生成合成、逼真的数据为克服这些限制提供了一种潜在解决方案，近期研究表明，微调基础模型能够有效生成此类数据。在本研究中，我们探索基础模型在生成逼真医学图像（尤其是胸部 X 光片）方面的潜力，并评估其性能如何通过微调得到提升。我们提出使用 Latent Diffusion Model（潜在扩散模型），从预训练的基础模型开始，并通过多种配置对其进行改进。此外，我们在医学专业人员输入的参与下开展实验，以评估每个训练模型所生成图像的逼真度。
英文摘要：
Machine learning has significantly advanced healthcare by aiding in disease prevention and treatment identification. However, accessing patient data can be challenging due to privacy concerns and strict regulations. Generating synthetic, realistic data offers a potential solution for overcoming these limitations, and recent studies suggest that fine-tuning foundation models can produce such data effectively. In this study, we explore the potential of foundation models for generating realistic medical images, particularly chest x-rays, and assess how their performance improves with fine-tuning. We propose using a Latent Diffusion Model, starting with a pre-trained foundation model and refining it through various configurations. Additionally, we performed experiments with input from a medical professional to assess the realism of the images produced by each trained model.
The use of smartphones to take photographs of chest x-rays represents an appealing solution for scaled deployment of deep learning models for chest x-ray interpretation. However, the performance of chest x-ray algorithms on photos of chest x-rays has not been thoroughly investigated. In this study, we measured the diagnostic performance for 8 different chest x-ray models when applied to photos of chest x-rays. All models were developed by different groups and submitted to the CheXpert challenge, and re-applied to smartphone photos of x-rays in the CheXphoto dataset without further tuning. We f…
Saratoga High School（萨拉托加高中）；Stanford University（斯坦福大学）
Chest X-rays of coronavirus disease 2019 (COVID-19) patients are frequently obtained to determine the extent of lung disease and are a valuable source of data for creating artificial intelligence models. Most work to date assessing disease severity on chest imaging has focused on segmenting computed tomography (CT) images; however, given that CTs are performed much less frequently than chest X-rays for COVID-19 patients, automated lung lesion segmentation on chest X-rays could be clinically valuable. There currently exists a universal shortage of chest X-rays with ground truth COVID-19 lung le…
University of Chittagong（吉大港大学）；Charles Sturt University（查尔斯特大学）
This paper proposed an ensemble of deep convolutional neural networks (CNN) based on EfficientNet, named ECOVNet, to detect COVID-19 using a large chest X-ray data set. At first, the open-access large chest X-ray collection is augmented, and then ImageNet pre-trained weights for EfficientNet is transferred with some customized fine-tuning top layers that are trained, followed by an ensemble of model snapshots to classify chest X-rays corresponding to COVID-19, normal, and pneumonia. The predictions of the model snapshots, which are created during a single training, are combined through two ens…
COVID-19 is a global pandemic, and detecting them is a momentous task for medical professionals today due to its rapid mutations. Current methods of examining chest X-rays and CT scan requires profound knowledge and are time consuming, which suggests that it shrinks the precious time of medical practitioners when people's lives are at stake. This study tries to assist this process by achieving state-of-the-art performance in classifying chest X-rays by fine-tuning Vision Transformer(ViT). The proposed approach uses pretrained models, fine-tuned for detecting the presence of COVID-19 disease on…
IBM Watson Health Imaging（IBM沃森健康影像）；Baptist Health South Florida（南佛罗里达浸信会健康）；Brigham and Women’s Hospital（布莱根妇女医院）
Chest x-ray imaging is widely used for the diagnosis of pneumothorax and there has been significant interest in developing automated methods to assist in image interpretation. We present an image classification pipeline which detects pneumothorax as well as the various types of chest tubes that are commonly used to treat pneumothorax. Our multi-stage algorithm is based on lung segmentation followed by pneumothorax classification, including classification of patches that are most likely to contain pneumothorax. This algorithm achieves state of the art performance for pneumothorax classification…
Wayne State Univ.（韦恩州立大学）；NanoBioScience Institute, Wayne State Univ.（韦恩州立大学纳米生物科学研究所）；University of Michigan（密歇根大学）；Henry Ford Health System（亨利福特医疗系统）
Deep Neural Networks (DNN) are widely used to carry out segmentation tasks in biomedical images. Most DNNs developed for this purpose are based on some variation of the encoder-decoder U-Net architecture. Here we show that Res-CR-Net, a new type of fully convolutional neural network, which was originally developed for the semantic segmentation of microscopy images, and which does not adopt a U-Net architecture, is very effective at segmenting the lung fields in chest X-rays from either healthy patients or patients with a variety of lung pathologies.
Recent advances in training deep learning models have demonstrated the potential to provide accurate chest X-ray interpretation and increase access to radiology expertise. However, poor generalization due to data distribution shifts in clinical settings is a key barrier to implementation. In this study, we measured the diagnostic performance for 8 different chest X-ray models when applied to (1) smartphone photos of chest X-rays and (2) external datasets without any finetuning. All models were developed by different groups and submitted to the CheXpert challenge, and re-applied to test dataset…
UT Austin（得克萨斯大学奥斯汀分校）；MIS, Germany（德国曼海姆应用科学大学）；Weill Cornell Medicine（威尔康奈尔医学院）
Computer-aided diagnosis plays a salient role in more accessible and accurate cardiopulmonary diseases classification and localization on chest radiography. Millions of people get affected and die due to these diseases without an accurate and timely diagnosis. Recently proposed contrastive learning heavily relies on data augmentation, especially positive data augmentation. However, generating clinically-accurate data augmentations for medical images is extremely difficult because the common data augmentation methods in computer vision, such as sharp, blur, and crop operations, can severely alt…
Chest X-rays are the most common diagnostic exams in emergency rooms and hospitals. There has been a surge of work on automatic interpretation of chest X-rays using deep learning approaches after the availability of large open source chest X-ray dataset from NIH. However, the labels are not sufficiently rich and descriptive for training classification tools. Further, it does not adequately address the findings seen in Chest X-rays taken in anterior-posterior (AP) view which also depict the placement of devices such as central vascular lines and tubes. In this paper, we present a new chest X-ra…
Bauman Moscow State Technical University（鲍曼莫斯科国立技术大学）
The possibility of high-precision and rapid detection of pathologies on chest X-rays makes it possible to detect the development of pneumonia at an early stage and begin immediate treatment. Artificial intelligence can speed up and qualitatively improve the procedure of X-ray analysis and give recommendations to the doctor for additional consideration of suspicious images. The purpose of this study is to determine the best models and implementations of the transfer learning method in the binary classification problem in the presence of a small amount of training data. In this article, various …
University of South Florida（南佛罗里达大学）；University of California, San Francisco（加利福尼亚大学旧金山分校）
Testing for COVID-19 has been unable to keep up with the demand. Further, the false negative rate is projected to be as high as 30% and test results can take some time to obtain. X-ray machines are widely available and provide images for diagnosis quickly. This paper explores how useful chest X-ray images can be in diagnosing COVID-19 disease. We have obtained 122 chest X-rays of COVID-19 and over 4,000 chest X-rays of viral and bacterial pneumonia. A pretrained deep convolutional neural network has been tuned on 102 COVID-19 cases and 102 other pneumonia cases in a 10-fold cross validation. T…
Scientific Computing and Imaging Institute, University of Utah（犹他大学科学计算与成像研究所）；Department of Radiology and Imaging Sciences, University of Utah（犹他大学放射学与影像科学系）
Knowledge of what spatial elements of medical images deep learning methods use as evidence is important for model interpretability, trustiness, and validation. There is a lack of such techniques for models in regression tasks. We propose a method, called visualization for regression with a generative adversarial network (VR-GAN), for formulating adversarial training specifically for datasets containing regression target values characterizing disease severity. We use a conditional generative adversarial network where the generator attempts to learn to shift the output of a regressor through cre…
IBM Research（IBM研究院）；University of Illinois Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）
Central venous catheters (CVCs) are commonly used in critical care settings for monitoring body functions and administering medications. They are often described in radiology reports by referring to their presence, identity and placement. In this paper, we address the problem of automatic detection of their presence and identity through automated segmentation using deep learning networks and classification based on their intersection with previously learned shape priors from clinician annotations of CVCs. The results not only outperform existing methods of catheter detection achieving 85.2% ac…
Stanford University（斯坦福大学）；University of California, Berkeley（加州大学伯克利分校）；IBM Almaden Research Center（IBM阿尔马登研究中心）
Chest X-rays have become the focus of vigorous deep learning research in recent years due to the availability of large labeled datasets. While classification of anomalous findings is now possible, ensuring that they are correctly localized still remains challenging, as this requires recognition of anomalies within anatomical regions. Existing deep learning networks for fine-grained anomaly classification learn location-specific findings using architectures where the location and spatial contiguity information is lost during the flattening step before classification. In this paper, we present a…
Sierra Research S.L（塞拉研究有限公司）；Universidad de Alicante（阿利坎特大学）；Medbravo（Medbravo医疗公司）；Fundación para el Fomento de la Investigación Sanitario y Biomédica de la Comunidad Valenciana（瓦伦西亚自治区卫生与生物医学研究促进基金会）；Hospital San Juan de Alicante（阿利坎特圣胡安医院）；Universidad Miguel Hernández（米格尔·埃尔南德斯大学）
In this work we present a method for the detection of radiological findings, their location and differential diagnoses from chest x-rays. Unlike prior works that focus on the detection of few pathologies, we use a hierarchical taxonomy mapped to the Unified Medical Language System (UMLS) terminology to identify 189 radiological findings, 22 differential diagnosis and 122 anatomic locations, including ground glass opacities, infiltrates, consolidations and other radiological findings compatible with COVID-19. We train the system on one large database of 92,594 frontal chest x-rays (AP or PA, st…
University of Utah（犹他大学）；Scientific Computing and Imaging Institute（科学计算与成像研究所）
Deep learning has shown recent success in classifying anomalies in chest x-rays, but datasets are still small compared to natural image datasets. Supervision of abnormality localization has been shown to improve trained models, partially compensating for dataset sizes. However, explicitly labeling these anomalies requires an expert and is very time-consuming. We propose a potentially scalable method for collecting implicit localization data using an eye tracker to capture gaze locations and a microphone to capture a dictation of a report, imitating the setup of a reading room. The resulting RE…
Technical University of Munich（慕尼黑工业大学）；Klinikum rechts der Isar（伊萨尔河畔临床教学中心）
Deep learning models used in medical image analysis are prone to raising reliability concerns due to their black-box nature. To shed light on these black-box models, previous works predominantly focus on identifying the contribution of input features to the diagnosis, i.e., feature attribution. In this work, we explore counterfactual explanations to identify what patterns the models rely on for diagnosis. Specifically, we investigate the effect of changing features within chest X-rays on the classifier's output to understand its decision mechanism. We leverage a StyleGAN-based approach (StyleE…
The University of Texas at Arlington（德克萨斯大学阿灵顿分校）；Tencent AI Lab（腾讯人工智能实验室）
Chest X-rays is one of the most commonly available and affordable radiological examinations in clinical practice. While detecting thoracic diseases on chest X-rays is still a challenging task for machine intelligence, due to 1) the highly varied appearance of lesion areas on X-rays from patients of different thoracic disease and 2) the shortage of accurate pixel-level annotations by radiologists for model training. Existing machine learning methods are unable to deal with the challenge that thoracic diseases usually happen in localized disease-specific areas. In this article, we propose a weak…
We develop an algorithm that can detect pneumonia from chest X-rays at a level exceeding practicing radiologists. Our algorithm, CheXNet, is a 121-layer convolutional neural network trained on ChestX-ray14, currently the largest publicly available chest X-ray dataset, containing over 100,000 frontal-view X-ray images with 14 diseases. Four practicing academic radiologists annotate a test set, on which we compare the performance of CheXNet to that of radiologists. We find that CheXNet exceeds average radiologist performance on the F1 metric. We extend CheXNet to detect all 14 diseases in ChestX…
Over the last year, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants have highlighted the importance of screening tools with high diagnostic accuracy for new illnesses such as COVID-19. To that regard, deep learning approaches have proven as effective solutions for pneumonia classification, especially when considering chest-x-rays images. However, this lung infection can also be caused by other viral, bacterial or fungi pathogens. Consequently, efforts are being poured toward distinguishing the infection source to help clinicians to diagnose the correct disease…
Vellore Institute of Technology, Chennai（韦洛尔理工学院（金奈校区））
Tuberculosis is an infectious disease that is leading to the death of millions of people across the world. The mortality rate of this disease is high in patients suffering from immuno-compromised disorders. The early diagnosis of this disease can save lives and can avoid further complications. But the diagnosis of TB is a very complex task. The standard diagnostic tests still rely on traditional procedures developed in the last century. These procedures are slow and expensive. So this paper presents an automatic approach for the diagnosis of TB from posteroanterior chest x-rays. This is a two-…
Harvard University（哈佛大学）；Institute for Applied Computational Science（应用计算科学研究所）
Heart failure remains a major public health challenge with growing costs. Ejection fraction (EF) is a key metric for the diagnosis and management of heart failure however estimation of EF using echocardiography remains expensive for the healthcare system and subject to intra/inter operator variability. While chest x-rays (CXR) are quick, inexpensive, and require less expertise, they do not provide sufficient information to the human eye to estimate EF. This work explores the efficacy of computer vision techniques to predict reduced EF solely from CXRs. We studied a dataset of 3488 CXRs from th…
Mohamed bin Zayed University of Artificial Intelligence（穆罕默德·本·扎耶德人工智能大学）
Quick and accurate diagnosis is of paramount importance to mitigate the effects of COVID-19 infection, particularly for severe cases. Enormous effort has been put towards developing deep learning methods to classify and detect COVID-19 infections from chest radiography images. However, recently some questions have been raised surrounding the clinical viability and effectiveness of such methods. In this work, we investigate the impact of multi-task learning (classification and segmentation) on the ability of CNNs to differentiate between various appearances of COVID-19 infections in the lung. W…
University of Leeds（利兹大学）；Leeds Teaching Hospitals NHS Trust（利兹教学医院 NHS 信托基金）
Since the emergence of COVID-19, deep learning models have been developed to identify COVID-19 from chest X-rays. With little to no direct access to hospital data, the AI community relies heavily on public data comprising numerous data sources. Model performance results have been exceptional when training and testing on open-source data, surpassing the reported capabilities of AI in pneumonia-detection prior to the COVID-19 outbreak. In this study impactful models are trained on a widely used open-source data and tested on an external test set and a hospital dataset, for the task of classifyin…
Purpose: We present image classifiers based on Dense Convolutional Networks and transfer learning to classify chest X-ray images according to three labels: COVID-19, pneumonia and normal. Methods: We fine-tuned neural networks pretrained on ImageNet and applied a twice transfer learning approach, using NIH ChestX-ray14 dataset as an intermediate step. We also suggested a novelty called output neuron keeping, which changes the twice transfer learning technique. In order to clarify the modus operandi of the models, we used Layer-wise Relevance Propagation (LRP) to generate heatmaps. Results: We …
Background: Chest X-rays are the most commonly performed, cost-effective diagnostic imaging tests ordered by physicians. A clinically validated AI system that can reliably separate normals from abnormals can be invaluble particularly in low-resource settings. The aim of this study was to develop and validate a deep learning system to detect various abnormalities seen on a chest X-ray. Methods: A deep learning system was trained on 2.3 million chest X-rays and their corresponding radiology reports to identify various abnormalities seen on a Chest X-ray. The system was tested against - 1. A thre…
Seoul National University（首尔国立大学）；Hankuk University of Foreign Studies（韩国外国语大学）
Suppressing bones on chest X-rays such as ribs and clavicle is often expected to improve pathologies classification. These bones can interfere with a broad range of diagnostic tasks on pulmonary disease except for musculoskeletal system. Current conventional method for acquisition of bone suppressed X-rays is dual energy imaging, which captures two radiographs at a very short interval with different energy levels; however, the patient is exposed to radiation twice and the artifacts arise due to heartbeats between two shots. In this paper, we introduce a deep generative model trained to predict…
The potential of deep learning, especially in medical imaging, initiated astonishing results and improved the methodologies after every passing day. Deep learning in radiology provides the opportunity to classify, detect and segment different diseases automatically. In the proposed study, we worked on a non-trivial aspect of medical imaging where we classified and localized the X-Rays affected by bullets. We tested Images on different classification and localization models to get considerable accuracy. The replicated data set used in the study was replicated on different images of chest X-Rays…
Indian Institute of Technology Delhi（印度德里理工学院）；Teleradiology Solutions（远程放射学解决方案公司）；CSIR-Institute of Genomics and Integrative Biology（CSIR基因组学与整合生物学研究所）；Christian Medical College（基督教医学院）
Background and Objective: Tuberculosis (TB) is a significant public health issue and a leading cause of death worldwide. Millions of deaths can be averted by early diagnosis and successful treatment of TB patients. Automated diagnosis of TB holds vast potential to assist medical experts in expediting and improving its diagnosis, especially in developing countries like India, where there is a shortage of trained medical experts and radiologists. To date, several deep learning based methods for automated detection of TB from chest radiographs have been proposed. However, the performance of a few…
Acute Care Solutions（急性护理解决方案）；Philips Research North America（飞利浦北美研究院）
The MIMIC-CXR dataset is (to date) the largest released chest x-ray dataset consisting of 473,064 chest x-rays and 206,574 radiology reports collected from 63,478 patients. We present the results of training and evaluating a collection of deep convolutional neural networks on this dataset to recognize multiple common thorax diseases. To the best of our knowledge, this is the first work that trains CNNs for this task on such a large collection of chest x-ray images, which is over four times the size of the largest previously released chest x-ray corpus (ChestX-Ray14). We describe and evaluate i…
Mila, Quebec Artificial Intelligence Institute（米拉-魁北克人工智能研究所）；Université de Montréal（蒙特利尔大学）
Most deep learning models in chest X-ray prediction utilize the posteroanterior (PA) view due to the lack of other views available. PadChest is a large-scale chest X-ray dataset that has almost 200 labels and multiple views available. In this work, we use PadChest to explore multiple approaches to merging the PA and lateral views for predicting the radiological labels associated with the X-ray image. We find that different methods of merging the model utilize the lateral view differently. We also find that including the lateral view increases performance for 32 labels in the dataset, while bei…
Cupertino High School（库比蒂诺高中）；Stanford University（斯坦福大学）
Coronavirus disease 2019 (COVID-19) is the highly contagious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The standard diagnostic testing procedure for COVID-19 is testing a nasopharyngeal swab for SARS-CoV-2 nucleic acid using a real-time polymerase chain reaction (PCR), which can take multiple days to provide a diagnosis. Another widespread form of testing is rapid antigen testing, which has a low sensitivity compared to PCR, but is favored for its quick diagnosis time of usually 15-30 minutes. Patients who test positive for COVID-19 demonstrate diffuse alv…
Department of Radiology and Imaging Sciences, Clinical Center（临床中心放射与影像科学系）
Chest X-rays are one of the most common radiological examinations in daily clinical routines. Reporting thorax diseases using chest X-rays is often an entry-level task for radiologist trainees. Yet, reading a chest X-ray image remains a challenging job for learning-oriented machine intelligence, due to (1) shortage of large-scale machine-learnable medical image datasets, and (2) lack of techniques that can mimic the high-level reasoning of human radiologists that requires years of knowledge accumulation and professional training. In this paper, we show the clinical free-text radiological repor…
X-rays are commonly performed imaging tests that use small amounts of radiation to produce pictures of the organs, tissues, and bones of the body. X-rays of the chest are used to detect abnormalities or diseases of the airways, blood vessels, bones, heart, and lungs. In this work we present a stochastic attention-based model that is capable of learning what regions within a chest X-ray scan should be visually explored in order to conclude that the scan contains a specific radiological abnormality. The proposed model is a recurrent neural network (RNN) that learns to sequentially sample the ent…
Virginia Tech（弗吉尼亚理工大学）；IBM Research（IBM研究院）；Institute for Medical Engineering and Science, Massachusetts Institute of Technology（麻省理工学院医学工程与科学研究所）；Beth Israel Deaconess Medical Center（贝斯以色列女执事医疗中心）；Harvard T.H. Chan School of Public Health（哈佛陈曾熙公共卫生学院）；University of British Columbia（不列颠哥伦比亚大学）
Despite the progress in utilizing deep learning to automate chest radiograph interpretation and disease diagnosis tasks, change between sequential Chest X-rays (CXRs) has received limited attention. Monitoring the progression of pathologies that are visualized through chest imaging poses several challenges in anatomical motion estimation and image registration, i.e., spatially aligning the two images and modeling temporal dynamics in change detection. In this work, we propose CheXRelNet, a neural model that can track longitudinal pathology change relations between two CXRs. CheXRelNet incorpor…
Tuberculosis (TB) is a contagious bacterial airborne disease, and is one of the top 10 causes of death worldwide. According to the World Health Organization (WHO), around 1.8 billion people are infected with TB and 1.6 million deaths were reported in 2018. More importantly,95% of cases and deaths were from developing countries. Yet, TB is a completely curable disease through early diagnosis. To achieve this goal one of the key requirements is efficient utilization of existing diagnostic technologies, among which chest X-ray is the first line of diagnostic tool used for screening for active TB.…
University of Oulu（奥卢大学）；Oulu University Hospital（奥卢大学医院）；Oxipit UAB
Objectives: To assess the use of artificial intelligence-based software in ruling out chest X-ray cases, with no significant findings in a primary health care setting. Methods: In this retrospective study, a commercially available artificial intelligence (AI) software was used to analyse 10 000 chest X-rays of Finnish primary health care patients. In studies with a mismatch between an AI normal report and the original radiologist report, a consensus read by two board-certified radiologists was conducted to make the final diagnosis. Results: After the exclusion of cases not meeting the study cr…
University of Warwick（华威大学）；Guy’s and St Thomas’ NHS Foundation Trust（盖伊和圣托马斯国民保健服务基金会信托）；University Hospitals Coventry and Warwickshire NHS Trust（考文垂与沃里克郡大学医院国民保健服务信托）；Guy’s and St Thomas’ NHS Trust（盖伊和圣托马斯国民保健服务信托）；King’s College London（伦敦国王学院）；The Alan Turing Institute（艾伦·图灵研究所）
Understanding the internal physiological changes accompanying the aging process is an important aspect of medical image interpretation, with the expected changes acting as a baseline when reporting abnormal findings. Deep learning has recently been demonstrated to allow the accurate estimation of patient age from chest X-rays, and shows potential as a health indicator and mortality predictor. In this paper we present a novel comparative study of the relative performance of radiologists versus state-of-the-art deep learning models on two tasks: (a) patient age estimation from a single chest X-r…
SharpXR: Structure-Aware Denoising for Pediatric Chest X-Rays
Federal University of Agriculture Abeokuta, Nigeria（尼日利亚阿贝奥库塔联邦农业大学）；University of Lagos, Nigeria（尼日利亚拉各斯大学）；University of Nigeria, Nsukka（尼日利亚恩苏克卡大学）；University of Benin, Nigeria（尼日利亚贝宁大学）；Olabisi Onabanjo University, Nigeria（尼日利亚奥拉比·奥纳班乔大学）；Federal University of Technology, Minna, Nigeria（尼日利亚米纳联邦技术大学）；McGill University, Canada（加拿大麦吉尔大学）；AGH University of Krakow, Poland（波兰克拉科夫AGH大学）
IPPM RAS, Russian Academy of Sciences（俄罗斯科学院IPPM）；Aalto University（阿尔托大学）；Oulu University Hospital（奥卢大学医院）；University of Oulu（奥卢大学）
Cardiothoratic ratio (CTR) estimated from chest radiographs is a marker indicative of cardiomegaly, the presence of which is in the criteria for heart failure diagnosis. Existing methods for automatic assessment of CTR are driven by Deep Learning-based segmentation. However, these techniques produce only point estimates of CTR but clinical decision making typically assumes the uncertainty. In this paper, we propose a novel method for chest X-ray segmentation and CTR assessment in an automatic manner. In contrast to the previous art, we, for the first time, propose to estimate CTR with uncertai…
Jordan University of Science and Technology（约旦科技大学）；Staffordshire University（斯塔福德郡大学）
Pneumothorax, also called a collapsed lung, refers to the presence of the air in the pleural space between the lung and chest wall. It can be small (no need for treatment), or large and causes death if it is not identified and treated on time. It is easily seen and identified by experts using a chest X-ray. Although this method is mostly error-free, it is time-consuming and needs expert radiologists. Recently, Computer Vision has been providing great assistance in detecting and segmenting pneumothorax. In this paper, we propose a 2-Stage Training system (2ST-UNet) to segment images with pneumo…
The University of Texas at Austin（德克萨斯大学奥斯汀分校）；Weill Cornell Medicine（威尔康奈尔医学院）
Chest X-ray becomes one of the most common medical diagnoses due to its noninvasiveness. The number of chest X-ray images has skyrocketed, but reading chest X-rays still have been manually performed by radiologists, which creates huge burnouts and delays. Traditionally, radiomics, as a subfield of radiology that can extract a large number of quantitative features from medical images, demonstrates its potential to facilitate medical imaging diagnosis before the deep learning era. In this paper, we develop an end-to-end framework, ChexRadiNet, that can utilize the radiomics features to improve t…
G.B. Pant Government Engineering College（G.B. Pant政府工程学院）
Coronavirus is a large virus family consisting of diverse viruses, some of which disseminate among mammals and others cause sickness among humans. COVID-19 is highly contagious and is rapidly spreading, rendering its early diagnosis of preeminent status. Researchers, medical specialists and organizations all over the globe have been working tirelessly to combat this virus and help in its containment. In this paper, a novel neural network called WisdomNet has been proposed, for the diagnosis of COVID-19 using chest X-rays. The WisdomNet uses the concept of Wisdom of Crowds as its founding idea.…
Purpose: The purpose of this study was to observe change in accuracies of convolutional neural networks (CNN) models (ratio of correct classifications to total predictions) on thoracic radiological images by creating different binary classification models based on age, gender, and image pre-processing filters on 14 pathologies. Methodology: This is a quantitative research exploring variation in CNN model accuracies. Radiological thoracic images were divided by age and gender and pre-processed by various image processing filters. Findings: We found partial support for enhancement to model accur…
Toronto Rehabilitation Institute, University Health Network（多伦多康复研究所，大学健康网络）；University of Toronto（多伦多大学）；University of Manitoba（曼尼托巴大学）
The current COVID-19 pandemic is now getting contained, albeit at the cost of morethan2.3million human lives. A critical phase in any pandemic is the early detection of cases to develop preventive treatments and strategies. In the case of COVID-19,several studies have indicated that chest radiography images of the infected patients show characteristic abnormalities. However, at the onset of a given pandemic, such asCOVID-19, there may not be sufficient data for the affected cases to train models for their robust detection. Hence, supervised classification is ill-posed for this problem because …
The University of Texas at Austin（德克萨斯大学奥斯汀分校）；Icahn School of Medicine at Mount Sinai（西奈山伊坎医学院）；Weill Cornell Medicine（威尔康奈尔医学院）
Building a highly accurate predictive model for classification and localization of abnormalities in chest X-rays usually requires a large number of manually annotated labels and pixel regions (bounding boxes) of abnormalities. However, it is expensive to acquire such annotations, especially the bounding boxes. Recently, contrastive learning has shown strong promise in leveraging unlabeled natural images to produce highly generalizable and discriminative features. However, extending its power to the medical image domain is under-explored and highly non-trivial, since medical images are much les…
