涨落流体动力学描述细胞聚集体中的输运
Fluctuating Hydrodynamics Describes Transport in Cellular Aggregates
AI总结：
本研究受细菌微菌落聚集动力学启发，提出活性多细胞聚集体模型，用宏观涨落理论推导其涨落流体动力学，发现团簇内输运系数降低、细致平衡不满足时爱因斯坦关系失效，为相关实验提供工具。
摘要：
细胞聚集体的生物学功能在很大程度上受其组成单个细胞的活性和位移影响。从理论角度来看，这种活性可通过扩散系数和电导率等流体动力学输运系数来表征。受细菌微菌落聚集动力学的启发，我们提出了一个活性多细胞聚集体模型，并利用最新发展的宏观涨落理论推导出该模型系统的涨落流体动力学方程。半解析理论和微观模拟均表明，流体动力学输运系数受非平衡微观参数影响，且在团簇内部显著降低。我们进一步发现，在不满足细致平衡的参数区间内，连接输运系数与涨落的爱因斯坦关系失效。本研究为肿瘤球、类器官等其他细胞聚集体系统中流体动力学输运的实验研究提供了有价值的工具。
英文摘要：
Biological functionality of cellular aggregates is largely influenced by the activity and displacements of individual constituent cells. From a theoretical perspective this activity can be characterized by hydrodynamic transport coefficients of diffusivity and conductivity. Motivated by the clustering dynamics of bacterial microcolonies we propose a model of active multicellular aggregates and use recently developed macroscopic fluctuation theory to derive a fluctuating hydrodynamics for this model system. Both semi-analytic theory and microscopic simulations show that the hydrodynamic transport coefficients are affected by non-equilibrium microscopic parameters and significantly decrease inside of the clusters. We further find that the Einstein relation connecting the transport coefficients and fluctuations breaks down in the parameter regime where the detailed balance is not satisfied. This study offers valuable tools for experimental investigation of hydrodynamic transport in other systems of cellular aggregates such as tumor spheroids and organoids.
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