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arXiv 2408.00527cs.LG
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自适应邻域对比学习用于三维刚度图的脑龄预测

Contrastive Learning with Adaptive Neighborhoods for Brain Age Prediction on 3D Stiffness Maps

University of Cambridge(剑桥大学);Cardiff University(卡迪夫大学);University of Delaware(特拉华大学)

Jakob Träuble, Lucy Hiscox, Curtis Johnson, Carola-Bibiane Schönlieb, Gabriele Kaminski Schierle, Angelica Aviles-Rivero

AI总结:

本文提出一种动态自适应局部邻域对比损失方法,首次将自监督学习应用于脑刚度图进行脑龄预测,持续优于现有最先进方法,为脑老化研究开辟新方向。

摘要:

在神经影像学领域,准确的脑龄预测对于揭示脑老化的复杂性以及识别神经退行性疾病的早期指标至关重要。自监督学习的最新进展,特别是对比学习,在处理复杂数据集时已展现出更强的鲁棒性。然而,当前方法在跨非均匀分布数据(这在医学影像场景中普遍存在)进行泛化时往往表现不足。为弥补这一差距,我们引入了一种新颖的对比损失,该损失在训练过程中动态自适应,聚焦于样本的局部邻域。此外,我们超越传统结构特征,纳入脑刚度——这一先前未被充分探索但因其对年龄相关变化的敏感性而具有前景的机械属性。本研究首次将自监督学习应用于脑机械属性,利用来自多项临床研究汇编的刚度图来预测脑龄。我们的方法以动态局部损失为特色,持续优于现有最先进方法,展现出卓越性能,并为脑老化研究开辟了新方向。

英文摘要:

In the field of neuroimaging, accurate brain age prediction is pivotal for uncovering the complexities of brain aging and pinpointing early indicators of neurodegenerative conditions. Recent advancements in self-supervised learning, particularly in contrastive learning, have demonstrated greater robustness when dealing with complex datasets. However, current approaches often fall short in generalizing across non-uniformly distributed data, prevalent in medical imaging scenarios. To bridge this gap, we introduce a novel contrastive loss that adapts dynamically during the training process, focusing on the localized neighborhoods of samples. Moreover, we expand beyond traditional structural features by incorporating brain stiffness - a mechanical property previously underexplored yet promising due to its sensitivity to age-related changes. This work presents the first application of self-supervised learning to brain mechanical properties, using compiled stiffness maps from various clinical studies to predict brain age. Our approach, featuring dynamic localized loss, consistently outperforms existing state-of-the-art methods, demonstrating superior performance and paving the way for new directions in brain aging research.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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