通过载药磁性电纺纤维实现释放的远程控制激活
Remote-Controlled Activation of the Release through Drug-Loaded Magnetic Electrospun Fibers
AI总结：
本研究提出一种基于电纺磁性纤维结合药物、磁性纳米颗粒和介孔二氧化硅纳米颗粒的新型药物释放平台，通过交变磁场实现亲水及疏水药物的精细可控释放，在5分钟内升温达8°C，在透皮给药等领域具应用前景。
摘要：
将磁性纳米颗粒整合到纤维状结构中，为治疗剂的远程控制释放提供了一条有趣的途径。本研究提出了一种基于电纺磁性纤维（EMFs）的新型药物释放平台，该平台结合了药物、磁性纳米颗粒（MNPs）和介孔二氧化硅纳米颗粒（MSNs），通过交变磁场（AMF）实现可控的药物递送。该平台被证明对亲水性酮咯酸（KET）和疏水性姜黄素（CUR）的包封具有通用性和有效性，并且使用纤维内载有药物的MSNs实现了对AMF触发释放的主要响应，从而对药物释放模式提供了精细控制。EMFs表现出优异的感应加热能力，在5分钟的AMF脉冲内温度升高达到8 °C。该系统在透皮疼痛管理、肿瘤药物递送、组织工程和伤口愈合等应用中显示出良好的前景，能够在空间和时间维度上实现对药物释放的精确控制。本研究的发现为开发基于可远程调节的多功能材料的下一代智能药物递送系统提供了有价值的见解，并有望彻底改变纳米医学领域。
英文摘要：
The integration of magnetic nanoparticles within fibrillar structures represents an interesting avenue for the remotely controlled release of therapeutic agents. This work presents a novel drug release platform based on electrospun magnetic fibers (EMFs) combining drugs, magnetic nanoparticles (MNPs) and mesoporous silica nanoparticles (MSNs) for controlled drug delivery via alternating magnetic fields (AMF). The platform was demonstrated to be versatile and effective for hydrophilic ketorolac (KET) and hydrophobic curcumin (CUR) encapsulation and the major response observed for AMF-triggered release was reached using drug-loaded MSNs within the fibers, providing fine control over drug release patterns. The EMFs exhibited excellent inductive heating capabilities, showing a temperature increase up to 8 °C within a 5 min AMF pulse. The system is shown to be promising for applications like transdermal pain management, oncological drug delivery, tissue engineering, and wound healing, enabling precise control over drug release in both spatial and temporal dimensions. The findings of this study offer valuable insights into the development of the next generation of smart drug delivery systems, based in multifunctional materials that can be remotely regulated and potentially revolutionize the field of nanomedicine.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
