磁场激活的热响应 PNIPAM/FeRh 智能复合材料用于阿霉素释放
Thermoresponsive PNIPAM/FeRh smart composite activated by magnetic field for doxorubicin release
AI总结：
本文构建磁场响应的 PNIPAM/FeRh 智能复合材料，利用 FeRh 磁热效应触发 PNIPAM 相变，实现 3 T 磁场下阿霉素可控释放，并验证其对 PMEF 细胞的高生物相容性。
摘要：
通过对 PNIPAM/FeRh 智能复合材料开展原位实验，证明了利用磁热效应控制热响应聚合物 PNIPAM 物理性质的能力。以阿霉素为例，展示了通过施加 3 T 磁场使智能复合材料中负载药物释放的概念。采用 IV-VIS 和拉曼光谱检测了施加磁场后药物的释放结果。体外研究表明，PNIPAM/FeRh 支架对原代小鼠胚胎成纤维细胞（PMEF）培养具有高度生物相容性。PMEF 有效黏附在 PNIPAM/FeRh 支架表面，并在接种后 72 h 内表现出较高的代谢和增殖活性。
英文摘要：
The ability to control by physical properties of the thermoresponsive polymer of PNIPAM by magnetocaloric effect was demonstrated by in-situ experiments on PNIPAM/FeRh smart composite. The concept of drug release loaded in smart composite by applying of 3 T magnetic field was demonstrated using an example of doxorubicin. Released results of the magnetic field applying the drug were detected using IV-VIS and Raman spectroscopy. In vitro, studies have demonstrated a high degree of PNIPAM/FeRh scaffold biocompatibility for primary mouse embryonic fibroblasts (PMEF) cell culture. PMEFs effectively ad-hered to the PNIPAM/FeRh scaffold surface and showed high metabolic and proliferative activity for 72 h after seeding.
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