光学宽场核磁共振显微镜
Optical Widefield Nuclear Magnetic Resonance Microscopy
AI总结：
本研究利用金刚石NV中心将核磁共振信号转为光学信号，由高速相机捕获，实现约10微米分辨率、235×150微米区域的宽场NMR成像，每个像素记录完整谱信息，融合光学与NMR技术推动多领域成像应用。
摘要：
显微镜技术能够实现微小结构或过程的详细可视化与理解。尽管相机已显著推动了光学、红外及电子显微镜的发展，但在相机上直接成像核磁共振（NMR）信号仍然难以实现。在此，我们利用金刚石中的氮-空位（NV）中心作为量子传感器，将NMR信号转换为光学信号，随后由高速相机捕获。与传统磁共振成像（MRI）不同，我们的方法在实空间的宽视场上记录NMR信号。我们证明，我们的光学宽场核磁共振显微镜（OMRM）能够在约235×150微米平方的区域内，以约10微米的分辨率对微流控结构中的NMR信号进行成像。关键在于，每个相机像素记录一个NMR谱，提供关于信号幅度、相位、局部磁场强度和梯度的多组分信息。光学显微镜与NMR技术的融合，为物理和生命科学中的多面成像应用开辟了道路。
英文摘要：
Microscopy enables detailed visualization and understanding of minute structures or processes. While cameras have significantly advanced optical, infrared, and electron microscopy, imaging nuclear magnetic resonance (NMR) signals on a camera has remained elusive. Here, we employ nitrogen-vacancy (NV) centers in diamond as a quantum sensor, which converts NMR signals into optical signals that are subsequently captured by a high-speed camera. Unlike traditional magnetic resonance imaging (MRI), our method records the NMR signal over a wide field of view in real space. We demonstrate that our optical widefield NMR microscopy (OMRM) can image NMR signals in microfluidic structures with a $\sim 10\,μm$ resolution across a $\sim 235 \times 150\,μm^2$ area. Crucially, each camera pixel records an NMR spectrum providing multicomponent information about the signal's amplitude, phase, local magnetic field strengths, and gradients. The fusion of optical microscopy and NMR techniques enables multifaceted imaging applications in the physical and life sciences.
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