磁体内阶段性运动下的加速实时电影与血流成像
Accelerated Real-time Cine and Flow under In-magnet Staged Exercise
AI总结：
针对运动期间定量运动负荷心血管磁共振成像（ExCMR）存在的运动伪影等技术挑战，本研究通过高加速率、线圈重加权及呼气末期心跳选择技术，在24名健康志愿者和6例患者中证明了磁体内阶段性运动下实时ExCMR评估双心室功能和血流动力学的可行性，提升了图像质量和参数重复性。
摘要：
背景：心血管磁共振成像（CMR）是诊断和管理心脏疾病的成熟成像工具。将运动负荷与CMR（ExCMR）结合可增强其诊断能力。尽管CMR技术近年取得进展，但运动期间的定量ExCMR因运动伪影及有限的空间和时间分辨率仍具技术挑战。方法：本研究在24名健康志愿者的阶段性运动方案中，探究使用实时（RT）ExCMR进行双心室功能和血流动力学评估的可行性。我们采用高加速率并应用线圈重加权技术以减少运动模糊和伪影，还应用呼气末期心跳选择技术，以降低呼吸诱导的平面运动对心功能定量的影响，并展示6例患者的结果以证明临床可行性。结果：研究发现不同运动强度下收缩末期容积持续减少、舒张末期容积稳定，导致每搏输出量和射血分数增加；9名志愿者的扫描-重扫测试显示，选择呼气末期心跳适度提高了心功能参数的重复性；盲法图像质量评估的高分表明线圈重加权有效减少了运动伪影。结论：本研究证明健康受试者和患者中磁体内运动RT ExCMR的可行性，结果显示高加速率、线圈重加权和呼吸相位特异性心跳选择可提升定量RT ExCMR的图像质量和重复性。
英文摘要：
Background: Cardiovascular magnetic resonance imaging (CMR) is a well established imaging tool for diagnosing and managing cardiac conditions. The integration of exercise stress with CMR (ExCMR) can enhance its diagnostic capacity. Despite recent advances in CMR technology, quantitative ExCMR during exercise remains technically challenging due to motion artifacts and limited spatial and temporal resolution. Methods: This study investigated the feasibility of biventricular functional and hemodynamic assessment using real-time (RT) ExCMR during a staged exercise protocol in 24 healthy volunteers. We employed high acceleration rates and applied a coil reweighting technique to minimize motion blurring and artifacts. We further applied a beat-selection technique that identified beats from the endexpiratory phase to minimize the impact of respiration-induced through-plane motion on cardiac function quantification. Additionally, results from six patients were presented to demonstrate clinical feasibility. Results: Our findings indicated a consistent decrease in end-systolic volume and stable end-diastolic volume across exercise intensities, leading to increased stroke volume and ejection fraction. The selection of end-expiratory beats modestly enhanced the repeatability of cardiac function parameters, as shown by scan-rescan tests in nine volunteers. High scores from a blinded image quality assessment indicated that coil reweighting effectively minimized motion artifacts. Conclusions: This study demonstrated the feasibility of RT ExCMR with inmagnet exercise in healthy subjects and patients. Our results indicate that high acceleration rates, coil reweighting, and selection of respiratory phase-specific heartbeats enhance image quality and repeatability of quantitative RT ExCMR.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
