SzCORE: A Seizure Community Open-source Research Evaluation framework for the validation of EEG-based automated seizure detection algorithms
EPFL（洛桑联邦理工学院）；ETH Zürich（苏黎世联邦理工学院）；Centre Hospitalier Universitaire Vaudois（沃州大学医疗中心）；University of Bologna（博洛尼亚大学）；Aarhus University Hospital（奥胡斯大学医院）；Danish Epilepsy Centre（丹麦癫痫中心）
Jonathan Dan, Una Pale, Alireza Amirshahi, William Cappelletti, Thorir Mar Ingolfsson, Xiaying Wang, Andrea Cossettini, Adriano Bernini, Luca Benini, Sándor Ben… 展开作者
Jonathan Dan, Una Pale, Alireza Amirshahi, William Cappelletti, Thorir Mar Ingolfsson, Xiaying Wang, Andrea Cossettini, Adriano Bernini, Luca Benini, Sándor Beniczky, David Atienza, Philippe Ryvlin
随着动态和长期脑电图（EEG）监测的日益普及，对基于EEG的高质量自动癫痫发作检测算法的需求变得更加迫切。这些算法验证方法的异质性影响了报告的结果，并使全面评估和比较具有挑战性。这种异质性尤其涉及数据集、评估方法和性能指标的选择。在本文中，我们提出了一个统一框架，旨在为基于EEG的癫痫发作检测算法的验证建立标准化。基于现有的指南和建议，该框架引入了与数据集、文件格式、EEG数据输入内容、癫痫发作标注输入和输出、交叉验证策略以及性能指标相关的一套建议和标准。我们还提出了10-20癫痫发作检测基准，这是一个基于转换为标准化格式的公共数据集的机器学习基准。该基准定义了机器学习任务以及报告指标。我们通过评估一组现有的癫痫发作检测算法来说明该基准的使用。SzCORE（Seizure Community Open-source Research Evaluation）框架和基准连同开源软件库一起公开发布，以促进研究使用，同时能够严格评估算法的临床意义，促进更优化地检测癫痫发作的集体努力，以改善癫痫患者的生活。
英文摘要：
The need for high-quality automated seizure detection algorithms based on electroencephalography (EEG) becomes ever more pressing with the increasing use of ambulatory and long-term EEG monitoring. Heterogeneity in validation methods of these algorithms influences the reported results and makes comprehensive evaluation and comparison challenging. This heterogeneity concerns in particular the choice of datasets, evaluation methodologies, and performance metrics. In this paper, we propose a unified framework designed to establish standardization in the validation of EEG-based seizure detection algorithms. Based on existing guidelines and recommendations, the framework introduces a set of recommendations and standards related to datasets, file formats, EEG data input content, seizure annotation input and output, cross-validation strategies, and performance metrics. We also propose the 10-20 seizure detection benchmark, a machine-learning benchmark based on public datasets converted to a standardized format. This benchmark defines the machine-learning task as well as reporting metrics. We illustrate the use of the benchmark by evaluating a set of existing seizure detection algorithms. The SzCORE (Seizure Community Open-source Research Evaluation) framework and benchmark are made publicly available along with an open-source software library to facilitate research use, while enabling rigorous evaluation of the clinical significance of the algorithms, fostering a collective effort to more optimally detect seizures to improve the lives of people with epilepsy.
Bayesian uncertainty-aware deep learning with noisy labels: Tackling annotation ambiguity in EEG seizure detection
Department of Electrical and Computer Engineering, Johns Hopkins University（约翰霍普金斯大学电气与计算机工程系）；Department of Electrical and Computer Engineering, Boston University（波士顿大学电气与计算机工程系）
IBM Research Australia（IBM澳大利亚研究院）；Google Health（谷歌健康）
Accurate classification of seizure types plays a crucial role in the treatment and disease management of epileptic patients. Epileptic seizure types not only impact the choice of drugs but also the range of activities a patient can safely engage in. With recent advances being made towards artificial intelligence enabled automatic seizure detection, the next frontier is the automatic classification of seizure types. On that note, in this paper, we explore the application of machine learning algorithms for multi-class seizure type classification. We used the recently released TUH EEG seizure cor…
Rutgers University（罗格斯大学）；Henry Ford Health System（亨利福特医疗系统）；Spectrum Health System（斯佩克特拉姆医疗系统）；Michigan State University（密歇根州立大学）
Developing a Brain-Computer Interface~(BCI) for seizure prediction can help epileptic patients have a better quality of life. However, there are many difficulties and challenges in developing such a system as a real-life support for patients. Because of the nonstationary nature of EEG signals, normal and seizure patterns vary across different patients. Thus, finding a group of manually extracted features for the prediction task is not practical. Moreover, when using implanted electrodes for brain recording massive amounts of data are produced. This big data calls for the need for safe storage …
Department of Electrical and Computer Engineering, McGill University（麦吉尔大学电气与计算机工程系）；Mila - Quebec AI Institute（Mila-魁北克人工智能研究所）
Electroencephalogram (EEG) signals are effective tools towards seizure analysis where one of the most important challenges is accurate detection of seizure events and brain regions in which seizure happens or initiates. However, all existing machine learning-based algorithms for seizure analysis require access to the labeled seizure data while acquiring labeled data is very labor intensive, expensive, as well as clinicians dependent given the subjective nature of the visual qualitative interpretation of EEG signals. In this paper, we propose to detect seizure channels and clips in a self-super…
Rensselaer Polytechnic Institute（伦斯勒理工学院）；IBM Thomas J. Watson Research Center（IBM托马斯·J·沃森研究中心）；Mount Sinai Hospital（西奈山医院）
Electroencephalogram (EEG) is a prominent way to measure the brain activity for studying epilepsy, thereby helping in predicting seizures. Seizure prediction is an active research area with many deep learning based approaches dominating the recent literature for solving this problem. But these models require a considerable number of patient-specific seizures to be recorded for extracting the preictal and interictal EEG data for training a classifier. The increase in sensitivity and specificity for seizure prediction using the machine learning models is noteworthy. However, the need for a signi…
The University of Western Australia（西澳大学）；University of Jeddah（吉达大学）
Seizure type identification is essential for the treatment and management of epileptic patients. However, it is a difficult process known to be time consuming and labor intensive. Automated diagnosis systems, with the advancement of machine learning algorithms, have the potential to accelerate the classification process, alert patients, and support physicians in making quick and accurate decisions. In this paper, we present a novel multi-path seizure-type classification deep learning network (MP-SeizNet), consisting of a convolutional neural network (CNN) and a bidirectional long short-term me…
Bharati Vidyapeeth’s College of Engineering（巴拉蒂维迪亚佩特工程学院）
The electroencephalogram (EEG) is one of the most precious technologies to understand the happenings inside our brain and further understand our body's happenings. Automatic prediction of oncoming seizures using the EEG signals helps the doctors and clinical experts and reduces their workload. This paper proposes an end-to-end deep learning algorithm to fully automate seizure prediction's laborious task without any heavy pre-processing on the EEG data or feature engineering. The proposed deep learning network is a blend of signal processing and deep learning pipeline, which automates the seizu…
Centre for Informatics and Systems of the University of Coimbra（科英布拉大学信息与系统中心）；University of Coimbra（科英布拉大学）
Refractory epileptic patients can suffer a seizure at any moment. Seizure prediction would substantially improve their lives. In this work, based on scalp EEG and its transformation into images, the likelihood of an epileptic seizure occurring at any moment is computed using an average of the softmax layer output (the likelihood) of a CNN, instead of the output of the classification layer. Results show that by analyzing the likelihood and thresholding it, prediction has higher sensitivity or a lower FPR/h. The best threshold for the likelihood was higher than 50% for 5 patients, and was lower …
EEG-Based Inter-Patient Epileptic Seizure Detection Combining Domain Adversarial Training with CNN-BiLSTM Network
Graduate School of Advanced Science and Engineering, Hiroshima University（Hiroshima大学先进科学与工程研究生院）；Department of Pediatric Neurology, Okayama University Hospital（Okayama大学医院儿科神经科）
Epilepsy is a chronic neurological disorder affecting 1\% of people worldwide, deep learning (DL) algorithms-based electroencephalograph (EEG) analysis provides the possibility for accurate epileptic seizure (ES) prediction, thereby benefiting patients suffering from epilepsy. To identify the preictal region that precedes the onset of seizure, a large number of annotated EEG signals are required to train DL algorithms. However, the scarcity of seizure onsets leads to significant insufficiency of data for training the DL algorithms. To overcome this data insufficiency, in this paper, we propose…
Multi-Branch Mutual-Distillation Transformer for EEG-Based Seizure Subtype Classification
Huazhong University of Science and Technology（华中科技大学）；Dongfeng Corporation Research & Development Institute（东风公司研发院）；China Electronic System Technology Co., Ltd.（中国电子系统技术有限公司）；Southern University of Science and Technology（南方科技大学）
Interpretable Multimodal EEG-ECG Framework for Neonatal Seizure Prediction and Patient-Adaptive Transfer Learning
Department of Electronic and Telecommunication Engineering, University of Moratuwa, Sri Lanka（电子与电信工程系，乌尔塔瓦大学，斯里兰卡）；Department of Biomedical Engineering, University of Melbourne, Australia（生物医学工程系，墨尔本大学，澳大利亚）；Department of Electrical and Computer Engineering, University of British Columbia, Canada（电气与计算机工程系，不列颠哥伦比亚大学，加拿大）；Department of Pediatrics, Faculty of Medicine, University of Colombo, Sri Lanka（儿科系，医学院，科伦坡大学，斯里兰卡）
Epilepsy is one of the most common and yet diverse set of chronic neurological disorders. This excessive or synchronous neuronal activity is termed seizure. Electroencephalogram signal processing plays a significant role in detection and prediction of epileptic seizures. In this paper we introduce an approach that relies upon the properties of wavelets for seizure detection. We utilise the Maximum Overlap Discrete Wavelet Transform which enables us to reduce signal noise Then from the variance exhibited in wavelet coefficients we develop connectivity and communication efficiency between the el…
BioSensics LLC（BioSensics有限责任公司）；Brown University（布朗大学）；University of Southern California（南加州大学）
Epilepsy is one of the most common neurological disorders, typically observed via seizure episodes. Epileptic seizures are commonly monitored through electroencephalogram (EEG) recordings due to their routine and low expense collection. The stochastic nature of EEG makes seizure identification via manual inspections performed by highly-trained experts a tedious endeavor, motivating the use of automated identification. The literature on automated identification focuses mostly on supervised learning methods requiring expert labels of EEG segments that contain seizures, which are difficult to obt…
University of Coimbra（科英布拉大学）；CISUC（科英布拉大学信息与系统中心）
The time series captured by a single scalp electrode (plus the reference electrode) of refractory epileptic patients is used to forecast seizures susceptibility. The time series is preprocessed, segmented, and each segment transformed into an image, using three different known methods: Recurrence Plot, Gramian Angular Field, Markov Transition Field. The likelihood of the occurrence of a seizure in a future predefined time window is computed by averaging the output of the softmax layer of a CNN, differently from the usual consideration of the output of the classification layer. By thresholding …
Epilepsy is one of the most common brain diseases that affect more than 1\% of the world's population. It is characterized by recurrent seizures, which come in different types and are treated differently. Electroencephalography (EEG) is commonly used in medical services to diagnose seizures and their types. The accurate identification of seizures helps to provide optimal treatment and accurate information to the patient. However, the manual diagnostic procedures of epileptic seizures are laborious and highly-specialized. Moreover, EEG manual evaluation is a process known to have a low inter-ra…
Canine EEG Helps Human: Cross-Species and Cross-Modality Epileptic Seizure Detection via Multi-Space Alignment
Ministry of Education Key Laboratory of Image Processing and Intelligent Control, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology（教育部图像处理与智能控制重点实验室，人工智能与自动化学院，华中科技大学）；Hubei Key Laboratory of Brain-inspired Intelligent Systems, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology（湖北省脑启发智能系统重点实验室，人工智能与自动化学院，华中科技大学）
University of New South Wales（新南威尔士大学）；Stanford University School of Medicine（斯坦福大学医学院）；Tsinghua University（清华大学）
Objective: Epilepsy is a chronic neurological disorder characterized by the occurrence of spontaneous seizures, which affects about one percent of the world's population. Most of the current seizure detection approaches strongly rely on patient history records and thus fail in the patient-independent situation of detecting the new patients. To overcome such limitation, we propose a robust and explainable epileptic seizure detection model that effectively learns from seizure states while eliminates the inter-patient noises. Methods: A complex deep neural network model is proposed to learn the p…
There is abundant medical data on the internet, most of which are unlabeled. Traditional supervised learning algorithms are often limited by the amount of labeled data, especially in the medical domain, where labeling is costly in terms of human processing and specialized experts needed to label them. They are also prone to human error and biased as a select few expert annotators label them. These issues are mitigated by Self-supervision, where we generate pseudo-labels from unlabelled data by seeing the data itself. This paper presents various self-supervision strategies to enhance the perfor…
Neurologists typically identify epileptic seizures from electroencephalograms (EEGs) by visual inspection. This process is often time-consuming, especially for EEG recordings that last hours or days. To expedite the process, a reliable, automated, and patient-independent seizure detector is essential. However, developing a patient-independent seizure detector is challenging as seizures exhibit diverse characteristics across patients and recording devices. In this study, we propose a patient-independent seizure detector to automatically detect seizures in both scalp EEG and intracranial EEG (iE…
Epilepsy is a brain disorder due to abnormalactivity of neurons and recording of seizures is of primary interest in the evaluation of epileptic patients. A seizureis the phenomenon of rhythmicity discharge from either a local area or the whole brain and the individual behavior usually lasts from seconds to minutes.In this work, empirical wavelet transform(EWT) is applied to decompose signals into Electroencephalography (EEG) rhythms. EEG signals are separated to delta, theta, alpha, beta and gamma rhythms using EWT.The proposed method has been evaluated by benchmark dataset which is freely dow…
Automated seizure detection and classification from electroencephalography (EEG) can greatly improve seizure diagnosis and treatment. However, several modeling challenges remain unaddressed in prior automated seizure detection and classification studies: (1) representing non-Euclidean data structure in EEGs, (2) accurately classifying rare seizure types, and (3) lacking a quantitative interpretability approach to measure model ability to localize seizures. In this study, we address these challenges by (1) representing the spatiotemporal dependencies in EEGs using a graph neural network (GNN) a…
Hiroshima University（广岛大学）；Okayama University Hospital（冈山大学医院）
In this paper, we propose a time-series stochastic model based on a scale mixture distribution with Markov transitions to detect epileptic seizures in electroencephalography (EEG). In the proposed model, an EEG signal at each time point is assumed to be a random variable following a Gaussian distribution. The covariance matrix of the Gaussian distribution is weighted with a latent scale parameter, which is also a random variable, resulting in the stochastic fluctuations of covariances. By introducing a latent state variable with a Markov chain in the background of this stochastic relationship,…
Northeast Yucai Foreign Language School（东北育才外国语学校）；Shenyang Pharmaceutical University（沈阳药科大学）；Northwestern University（西北大学）
The prediction of epileptic seizure has always been extremely challenging in medical domain. However, as the development of computer technology, the application of machine learning introduced new ideas for seizure forecasting. Applying machine learning model onto the predication of epileptic seizure could help us obtain a better result and there have been plenty of scientists who have been doing such works so that there are sufficient medical data provided for researchers to do training of machine learning models.
Electroencephalography (EEG), as the most common tool for epileptic seizure classification, contains useful information about different physiological states of the brain. Seizure related features in EEG signals can be better identified when localized in time frequency basis projections. In this work, a novel method for epileptic seizure classification based on wavelet packets (WPs) is presented in which both mother wavelet function and WP bases are adapted a posteriori to improve the seizure classification. A support vector machine (SVM) as classifier is used for seizure versus non-seizure EEG…
University College Cork（科克大学）；University of Parma（帕尔马大学）
EEG is the gold standard for seizure detection in the newborn infant, but EEG interpretation in the preterm group is particularly challenging; trained experts are scarce and the task of interpreting EEG in real-time is arduous. Preterm infants are reported to have a higher incidence of seizures compared to term infants. Preterm EEG morphology differs from that of term infants, which implies that seizure detection algorithms trained on term EEG may not be appropriate. The task of developing preterm specific algorithms becomes extra-challenging given the limited amount of annotated preterm EEG d…
Electroencephalography (EEG) analysis extracts critical information from brain signals, which has provided fundamental support for various applications, including brain-disease diagnosis and brain-computer interface. However, the real-time processing of large-scale EEG signals at high energy efficiency has placed great challenges for electronic processors on edge computing devices. Here, we propose the EEG opto-processor based on diffractive photonic computing units (DPUs) to effectively process the extracranial and intracranial EEG signals and perform epileptic seizure detection. The signals …
Long-Term EEG Partitioning for Seizure Onset Detection
SANKEN, Osaka University（大阪大学 SANKEN）；University of Illinois Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）；Carle Illinois College of Medicine, University of Illinois Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校卡尔伊利诺伊医学院）
Objective: The detection of epileptic seizures from scalp electroencephalogram (EEG) signals can facilitate early diagnosis and treatment. Previous studies suggested that the Gaussianity of EEG distributions changes depending on the presence or absence of seizures; however, no general EEG signal models can explain such changes in distributions within a unified scheme. Methods: This paper describes the formulation of a stochastic EEG model based on a multivariate scale mixture distribution that can represent changes in non-Gaussianity caused by stochastic fluctuations in EEG. In addition, we pr…
Epilepsy is a chronic neurological disorder affecting more than 65 million people worldwide and manifested by recurrent unprovoked seizures. The unpredictability of seizures not only degrades the quality of life of the patients, but it can also be life-threatening. Modern systems monitoring electroencephalography (EEG) signals are being currently developed with the view to detect epileptic seizures in order to alert caregivers and reduce the impact of seizures on patients' quality of life. Such seizure detection systems employ state-of-the-art machine learning algorithms that require a conside…
K. N. Toosi University of Technology（K. N. 图西理工大学）；Deakin University（迪肯大学）；University of Turku（图尔库大学）；Effat University（埃法特大学）；Ngee Ann Polytechnic（义安理工学院）；SUSS University（新跃社科大学）；Asia University（亚洲大学）
Epileptic seizures are one of the most crucial neurological disorders, and their early diagnosis will help the clinicians to provide accurate treatment for the patients. The electroencephalogram (EEG) signals are widely used for epileptic seizures detection, which provides specialists with substantial information about the functioning of the brain. In this paper, a novel diagnostic procedure using fuzzy theory and deep learning techniques is introduced. The proposed method is evaluated on the Bonn University dataset with six classification combinations and also on the Freiburg dataset. The tun…
Paris Brian Institute（巴黎大脑研究所）；CentraleSupélec（巴黎中央理工-高等电力学院）；National Centre for scientific research（法国国家科学研究中心）；Hôpital de La Pitié Salpêtrière（皮提耶-萨尔佩特里埃医院）
Epileptic seizure prediction has gained considerable interest in the computational Epilepsy research community. This paper presents a Machine Learning based method for epileptic seizure prediction which outperforms state-of-the art methods. We compute a probability for a given epoch, of being pre-ictal against interictal using the Random Forest classifier and introduce new concepts to enhance the robustness of the algorithm to false alarms. We assessed our method on 20 patients of the benchmark scalp EEG CHB-MIT dataset for a seizure prediction horizon (SPH) of 5 minutes and a seizure occurren…
Bilkent University（比尔肯特大学）；Institute for Infocomm Research（信息通信研究院）；KK Women's and Children's Hospital（KK妇女儿童医院）
This work aims to develop an end-to-end solution for seizure onset detection. We design the SeizNet, a Convolutional Neural Network for seizure detection. To compare SeizNet with traditional machine learning approach, a baseline classifier is implemented using spectrum band power features with Support Vector Machines (BPsvm). We explore the possibility to use the least number of channels for accurate seizure detection by evaluating SeizNet and BPsvm approaches using all channels and two channels settings respectively. EEG Data is acquired from 29 pediatric patients admitted to KK Woman's and C…
The use of EEG signal to diagnose several brain abnormalities is well-established in the literature. Particularly, epileptic seizure can be detected using EEG signals and several works were done in this field. The joint time-frequency domain features proved to be an improvement in classification results. This can be attributed to the non-stationarity inherent feature of the EEG signals. Therefore, shifting to the joint time-frequency domain benefits in utilizing the variations in time with respect to frequency and vice versa to obtain better outcomes. The Bayesian classifier is utilized to obt…
Accurate prediction of epileptic seizures allows patients to take preventive measures in advance to avoid possible injuries. In this work, a novel convolutional neural network (CNN) is proposed to analyze time, frequency, and channel information of electroencephalography (EEG) signals. The model uses three-dimensional (3D) kernels to facilitate the feature extraction over the three dimensions. The application of multiscale dilated convolution enables the 3D kernel to have more flexible receptive fields. The proposed CNN model is evaluated with the CHB-MIT EEG database, the experimental results…
Since the manual detection of electrographic seizures in continuous electroencephalogram (EEG) monitoring is very time-consuming and requires a trained expert, attempts to develop automatic seizure detection are diverse and ongoing. Machine learning approaches are intensely being applied to this problem due to their ability to classify seizure conditions from a large amount of data, and provide pre-screened results for neurologists. Several features, data transformations, and classifiers have been explored to analyze and classify seizures via EEG signals. In the literature, some jointly-applie…
Epilepsy is the second most common brain disorder after migraine. Automatic detection of epileptic seizures can considerably improve the patients' quality of life. Current Electroencephalogram (EEG)-based seizure detection systems encounter many challenges in real-life situations. The EEGs are non-stationary signals and seizure patterns vary across patients and recording sessions. Moreover, EEG data are prone to numerous noise types that negatively affect the detection accuracy of epileptic seizures. To address these challenges, we introduce the use of a deep learning-based approach that autom…
Monash University（莫纳什大学）；Alfred Health（阿尔弗雷德健康）；The University of Melbourne（墨尔本大学）；Faculty of Information Technology, Monash University（莫纳什大学信息技术学院）；St. Vincent’s Hospital, The University of Melbourne（墨尔本大学圣文森特医院）；Turner Institute for Brain and Mental Health, Monash University（莫纳什大学特纳脑与心理健康研究所）；Monash Biomedical Imaging, Monash University（莫纳什大学生物医学成像）；Wellcome Centre for Human Neuroimaging, UCL（伦敦大学学院人类神经成像威尔康姆中心）
With the advancement in artificial intelligence (AI) and machine learning (ML) techniques, researchers are striving towards employing these techniques for advancing clinical practice. One of the key objectives in healthcare is the early detection and prediction of disease to timely provide preventive interventions. This is especially the case for epilepsy, which is characterized by recurrent and unpredictable seizures. Patients can be relieved from the adverse consequences of epileptic seizures if it could somehow be predicted in advance. Despite decades of research, seizure prediction remains…
University of California at Berkeley（加州大学伯克利分校）；University of the Philippines Diliman（菲律宾大学迪利曼分校）；Chan-Zuckerberg Biohub（陈-扎克伯格生物中心）
Implantable devices that record neural activity and detect seizures have been adopted to issue warnings or trigger neurostimulation to suppress epileptic seizures. Typical seizure detection systems rely on high-accuracy offline-trained machine learning classifiers that require manual retraining when seizure patterns change over long periods of time. For an implantable seizure detection system, a low power, at-the-edge, online learning algorithm can be employed to dynamically adapt to the neural signal drifts, thereby maintaining high accuracy without external intervention. This work proposes S…
Automated seizure detection using clinical electroencephalograms is a challenging machine learning problem because the multichannel signal often has an extremely low signal to noise ratio. Events of interest such as seizures are easily confused with signal artifacts (e.g, eye movements) or benign variants (e.g., slowing). Commercially available systems suffer from unacceptably high false alarm rates. Deep learning algorithms that employ high dimensional models have not previously been effective due to the lack of big data resources. In this paper, we use the TUH EEG Seizure Corpus to evaluate …
