Epilepsy is one of the most common brain diseases that affect more than 1\% of the world's population. It is characterized by recurrent seizures, which come in different types and are treated differently. Electroencephalography (EEG) is commonly used in medical services to diagnose seizures and their types. The accurate identification of seizures helps to provide optimal treatment and accurate information to the patient. However, the manual diagnostic procedures of epileptic seizures are laborious and highly-specialized. Moreover, EEG manual evaluation is a process known to have a low inter-rater agreement among experts. This paper presents a novel automatic technique that involves extraction of specific features from EEG signals using Dual-tree Complex Wavelet Transform (DTCWT) and classifying them. We evaluated the proposed technique on TUH EEG Seizure Corpus (TUSZ) ver.1.5.2 dataset and compared the performance with existing state-of-the-art techniques using overall F1-score due to class imbalance seizure types. Our proposed technique achieved the best results of weighted F1-score of 99.1\% and 74.7\% for seizure-wise and patient-wise classification respectively, thereby setting new benchmark results for this dataset.
Epilepsy is one of the most common and yet diverse set of chronic neurological disorders. This excessive or synchronous neuronal activity is termed seizure. Electroencephalogram signal processing plays a significant role in detection and prediction of epileptic seizures. In this paper we introduce an approach that relies upon the properties of wavelets for seizure detection. We utilise the Maximum Overlap Discrete Wavelet Transform which enables us to reduce signal noise Then from the variance exhibited in wavelet coefficients we develop connectivity and communication efficiency between the el…
Electroencephalography (EEG), as the most common tool for epileptic seizure classification, contains useful information about different physiological states of the brain. Seizure related features in EEG signals can be better identified when localized in time frequency basis projections. In this work, a novel method for epileptic seizure classification based on wavelet packets (WPs) is presented in which both mother wavelet function and WP bases are adapted a posteriori to improve the seizure classification. A support vector machine (SVM) as classifier is used for seizure versus non-seizure EEG…
Epilepsy is a brain disorder due to abnormalactivity of neurons and recording of seizures is of primary interest in the evaluation of epileptic patients. A seizureis the phenomenon of rhythmicity discharge from either a local area or the whole brain and the individual behavior usually lasts from seconds to minutes.In this work, empirical wavelet transform(EWT) is applied to decompose signals into Electroencephalography (EEG) rhythms. EEG signals are separated to delta, theta, alpha, beta and gamma rhythms using EWT.The proposed method has been evaluated by benchmark dataset which is freely dow…
Shaheed Zulfikar Ali Bhutto Institute of Science and Technology（沙希德·祖尔菲卡尔·阿里·布托科学技术学院）；FAST National University of Computer and Emerging Sciences（FAST国家计算机与新兴科学大学）
Epilepsy is a disease in which frequent seizures occur due to abnormal activity of neurons. Patients affected by this disease can be treated with the help of medicines or surgical procedures. However, both of these methods are not quite useful. The only method to treat epilepsy patients effectively is to predict the seizure before its onset. It has been observed that abnormal activity in the brain signals starts before the occurrence of seizure known as the preictal state. Many researchers have proposed machine learning models for prediction of epileptic seizures by detecting the start of prei…
African Institute for Mathematical Sciences（非洲数学科学研究所）；Stellenbosch University（斯泰伦博斯大学）；Rochester Institute of Technology（罗切斯特理工学院）
This paper demonstrates the predictive superiority of discrete wavelet transform (DWT) over previously used methods of feature extraction in the diagnosis of epileptic seizures from EEG data. Classification accuracy, specificity, and sensitivity are used as evaluation metrics. We specifically show the immense potential of 2 combinations (DWT-db4 combined with SVM and DWT-db2 combined with RF) as compared to others when it comes to diagnosing epileptic seizures either in the balanced or the imbalanced dataset. The results also highlight that MFCC performs less than all the DWT used in this stud…
To define the neural networks responsible of the epileptic seizure, we had to study the electrophysiological signal in a proper way. The early recognition of the seizure build up could also be defined through the time space mapping of the preictal gamma oscillations. The electrophysiological signals present three types of wave: oscillations, spikes, and a mixture of both. Recent studies prove that spikes and oscillations should be separated efficiently to define the accurate neural connectivity for each activity. However retrieving the transitory activity is a sensitive task due to the frequen…
Epilepsy is a neurological condition such that it affects the brain and the nervous system. It is characterized by recurrent seizures, which are physical reactions to sudden, usually brief, excessive electrical discharges in a group of brain cells. Hence, seizure identification has great importance in clinical therapy of epileptic patients. Electroencephalogram (EEG) is one of the main biomarker that can measure voltage fluctuations of the brain and EEG data analysis helps to investigate the patient with epilepsy syndrome as epilepsy leaves their signature in EEG signals. In this paper, the Di…
Rensselaer Polytechnic Institute（伦斯勒理工学院）；IBM Thomas J. Watson Research Center（IBM托马斯·J·沃森研究中心）；Mount Sinai Hospital（西奈山医院）
Electroencephalogram (EEG) is a prominent way to measure the brain activity for studying epilepsy, thereby helping in predicting seizures. Seizure prediction is an active research area with many deep learning based approaches dominating the recent literature for solving this problem. But these models require a considerable number of patient-specific seizures to be recorded for extracting the preictal and interictal EEG data for training a classifier. The increase in sensitivity and specificity for seizure prediction using the machine learning models is noteworthy. However, the need for a signi…
Epileptic seizure detection and classification in clinical electroencephalogram data still is a challenge, and only low sensitivity with a high rate of false positives has been achieved with commercially available seizure detection tools, which usually are patient non-specific. Epilepsy patients suffer from severe detrimental effects like physical injury or depression due to unpredictable seizures. However, even in hospitals due to the high rate of false positives, the seizure alert systems are of poor help for patients as tools of seizure detection are mostly trained on unrealistically clean …
The University of Western Australia（西澳大学）；University of Jeddah（吉达大学）
Seizure type identification is essential for the treatment and management of epileptic patients. However, it is a difficult process known to be time consuming and labor intensive. Automated diagnosis systems, with the advancement of machine learning algorithms, have the potential to accelerate the classification process, alert patients, and support physicians in making quick and accurate decisions. In this paper, we present a novel multi-path seizure-type classification deep learning network (MP-SeizNet), consisting of a convolutional neural network (CNN) and a bidirectional long short-term me…
In this paper, we propose a personalized seizure detection and classification framework that quickly adapts to a specific patient from limited seizure samples. We achieve this by combining two novel paradigms that have recently seen much success in a wide variety of real-world applications: graph neural networks (GNN), and meta-learning. We train a Meta-GNN based classifier that learns a global model from a set of training patients such that this global model can eventually be adapted to a new unseen patient using very limited samples. We apply our approach on the TUSZ-dataset, one of the larg…
Electroencephalogram, an influential equipment for analyzing humans activities and recognition of seizure attacks can play a crucial role in designing accurate systems which can distinguish ictal seizures from regular brain alertness, since it is the first step towards accomplishing a high accuracy computer aided diagnosis system (CAD). In this article a novel approach for classification of ictal signals with wavelet based cross frequency coupling (CFC) is suggested. After extracting features by wavelet based CFC, optimal features have been selected by t-test and quadratic discriminant analysi…
Multi-Branch Mutual-Distillation Transformer for EEG-Based Seizure Subtype Classification
Huazhong University of Science and Technology（华中科技大学）；Dongfeng Corporation Research & Development Institute（东风公司研发院）；China Electronic System Technology Co., Ltd.（中国电子系统技术有限公司）；Southern University of Science and Technology（南方科技大学）
Automated seizure detection and classification from electroencephalography (EEG) can greatly improve seizure diagnosis and treatment. However, several modeling challenges remain unaddressed in prior automated seizure detection and classification studies: (1) representing non-Euclidean data structure in EEGs, (2) accurately classifying rare seizure types, and (3) lacking a quantitative interpretability approach to measure model ability to localize seizures. In this study, we address these challenges by (1) representing the spatiotemporal dependencies in EEGs using a graph neural network (GNN) a…
Epilepsy is a neurological brain disorder which life threatening and gives rise to recurrent seizures that are unprovoked. It occurs due to the abnormal chemical changes in our brain. Over the course of many years, studies have been conducted to support automatic diagnosis of epileptic seizures for the ease of clinicians. For that, several studies entail the use of machine learning methods for the early prediction of epileptic seizures. Mainly, feature extraction methods have been used to extract the right features from the EEG data generated by the EEG machine and then various machine learnin…
Epilepsy affects 50 million people worldwide and is one of the most common serious neurological disorders. Seizure detection and classification is a valuable tool for diagnosing and maintaining the condition. An automated classification algorithm will allow for accurate diagnosis. Utilising the Temple University Hospital (TUH) Seizure Corpus, six seizure types are compared; absence, complex partial, myoclonic, simple partial, tonic and tonic- clonic models. This study proposes a method that utilises unique features with a novel parallel classifier - Parallel Genetic Naive Bayes (NB) Seizure Cl…
Institute of Biomedical Informatics, University of Kentucky（肯塔基大学生物医学信息学研究所）；The University of Texas Health Science Center at Houston（德克萨斯大学休斯顿健康科学中心）
In current clinical practice, electroencephalograms (EEG) are reviewed and analyzed by well-trained neurologists to provide supports for therapeutic decisions. The way of manual reviewing is labor-intensive and error prone. Automatic and accurate seizure/nonseizure classification methods are needed. One major problem is that the EEG signals for seizure state and nonseizure state exhibit considerable variations. In order to capture essential seizure features, this paper integrates an emerging deep learning model, the independently recurrent neural network (IndRNN), with a dense structure and an…
Westlake University（西湖大学）；Zhejiang University School of Medicine Second Affiliated Hospital（浙江大学医学院附属第二医院）
An accurate seizure prediction system enables early warnings before seizure onset of epileptic patients. It is extremely important for drug-refractory patients. Conventional seizure prediction works usually rely on features extracted from Electroencephalography (EEG) recordings and classification algorithms such as regression or support vector machine (SVM) to locate the short time before seizure onset. However, such methods cannot achieve high-accuracy prediction due to information loss of the hand-crafted features and the limited classification ability of regression and SVM algorithms. We pr…
Seizure onset detection in electroencephalography (EEG) signals is a challenging task due to the non-stereotyped seizure activities as well as their stochastic and non-stationary characteristics in nature. Joint spectral-temporal features are believed to contain sufficient and powerful feature information for absence seizure detection. However, the resulting high-dimensional features involve redundant information and require heavy computational load. Here, we discover significant low-dimensional spectral-temporal features in terms of mean-standard deviation of wavelet transform coefficient (MS…
The University of Sydney（悉尼大学）；Royal Prince Alfred Hospital（皇家阿尔弗雷德王子医院）
Epilepsy affects nearly 1% of the global population, of which two thirds can be treated by anti-epileptic drugs and a much lower percentage by surgery. Diagnostic procedures for epilepsy and monitoring are highly specialized and labour-intensive. The accuracy of the diagnosis is also complicated by overlapping medical symptoms, varying levels of experience and inter-observer variability among clinical professions. This paper proposes a novel hybrid bilinear deep learning network with an application in the clinical procedures of epilepsy classification diagnosis, where the use of surface electr…
Centre for Informatics and Systems of the University of Coimbra（科英布拉大学信息与系统中心）；University of Coimbra（科英布拉大学）
Refractory epileptic patients can suffer a seizure at any moment. Seizure prediction would substantially improve their lives. In this work, based on scalp EEG and its transformation into images, the likelihood of an epileptic seizure occurring at any moment is computed using an average of the softmax layer output (the likelihood) of a CNN, instead of the output of the classification layer. Results show that by analyzing the likelihood and thresholding it, prediction has higher sensitivity or a lower FPR/h. The best threshold for the likelihood was higher than 50% for 5 patients, and was lower …
The analysis of electrophysiological signal of scalp: EEG (electroencephalography), MEG (magnetoencephalography) and depth (intracerebral EEG) IEEG is a way to delimit epileptogenic zone (EZ). These epileptic signals present two different activities (oscillations and spikes) which can be overlapped in the time frequency plane. Automatic recognition of epileptic seizure occurrence needs several preprocessing steps. In this study, we evaluated two filtering techniques: the stationary wavelet transforms (SWT) and the Despikifying in order to extract pre ictal gamma oscillations (bio markers of se…
University of Coimbra（科英布拉大学）；CISUC（科英布拉大学信息与系统中心）
The time series captured by a single scalp electrode (plus the reference electrode) of refractory epileptic patients is used to forecast seizures susceptibility. The time series is preprocessed, segmented, and each segment transformed into an image, using three different known methods: Recurrence Plot, Gramian Angular Field, Markov Transition Field. The likelihood of the occurrence of a seizure in a future predefined time window is computed by averaging the output of the softmax layer of a CNN, differently from the usual consideration of the output of the classification layer. By thresholding …
The use of EEG signal to diagnose several brain abnormalities is well-established in the literature. Particularly, epileptic seizure can be detected using EEG signals and several works were done in this field. The joint time-frequency domain features proved to be an improvement in classification results. This can be attributed to the non-stationarity inherent feature of the EEG signals. Therefore, shifting to the joint time-frequency domain benefits in utilizing the variations in time with respect to frequency and vice versa to obtain better outcomes. The Bayesian classifier is utilized to obt…
The two-point central difference is a common algorithm in biological signal processing and is particularly useful in analyzing physiological signals. In this paper, we develop a model-based classification method to detect epileptic seizures that relies on this algorithm to filter EEG signals. The underlying idea is to design an EEG filter that enhances the waveform of epileptic signals. The filtered signal is fitted to a quadratic linear-parabolic model using the curve fitting technique. The model fitting is assessed using four statistical parameters, which are used as classification features …
Since the manual detection of electrographic seizures in continuous electroencephalogram (EEG) monitoring is very time-consuming and requires a trained expert, attempts to develop automatic seizure detection are diverse and ongoing. Machine learning approaches are intensely being applied to this problem due to their ability to classify seizure conditions from a large amount of data, and provide pre-screened results for neurologists. Several features, data transformations, and classifiers have been explored to analyze and classify seizures via EEG signals. In the literature, some jointly-applie…
K. N. Toosi University of Technology（K. N. 图西理工大学）；Deakin University（迪肯大学）；University of Turku（图尔库大学）；Effat University（埃法特大学）；Ngee Ann Polytechnic（义安理工学院）；SUSS University（新跃社科大学）；Asia University（亚洲大学）
Epileptic seizures are one of the most crucial neurological disorders, and their early diagnosis will help the clinicians to provide accurate treatment for the patients. The electroencephalogram (EEG) signals are widely used for epileptic seizures detection, which provides specialists with substantial information about the functioning of the brain. In this paper, a novel diagnostic procedure using fuzzy theory and deep learning techniques is introduced. The proposed method is evaluated on the Bonn University dataset with six classification combinations and also on the Freiburg dataset. The tun…
Frankfurt Institute for Advanced Studies (FIAS)（法兰克福高等研究院）；Goethe University Frankfurt（法兰克福大学）；Center for Personalized Translational Epilepsy Research (CePTER)（个性化转化癫痫研究中心）
Epilepsy is the fourth most common neurological disorder, affecting about 1% of the population at all ages. As many as 60% of people with epilepsy experience focal seizures which originate in a certain brain area and are limited to part of one cerebral hemisphere. In focal epilepsy patients, a precise surgical removal of the seizure onset zone can lead to effective seizure control or even a seizure-free outcome. Thus, correct identification of the seizure onset zone is essential. For clinical evaluation purposes, electroencephalography (EEG) recordings are commonly used. However, their interpr…
Long-Term EEG Partitioning for Seizure Onset Detection
SANKEN, Osaka University（大阪大学 SANKEN）；University of Illinois Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）；Carle Illinois College of Medicine, University of Illinois Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校卡尔伊利诺伊医学院）
Identifying seizure activities in non-stationary electroencephalography (EEG) is a challenging task, since it is time-consuming, burdensome, and dependent on expensive human resources and subject to error and bias. A computerized seizure identification scheme can eradicate the above problems, assist clinicians and benefit epilepsy research. So far, several attempts were made to develop automatic systems to help neurophysiologists accurately identify epileptic seizures. In this research, a fully automated system is presented to automatically detect the various states of the epileptic seizure. T…
University of California at Berkeley（加州大学伯克利分校）；University of the Philippines Diliman（菲律宾大学迪利曼分校）；Chan-Zuckerberg Biohub（陈-扎克伯格生物中心）
Implantable devices that record neural activity and detect seizures have been adopted to issue warnings or trigger neurostimulation to suppress epileptic seizures. Typical seizure detection systems rely on high-accuracy offline-trained machine learning classifiers that require manual retraining when seizure patterns change over long periods of time. For an implantable seizure detection system, a low power, at-the-edge, online learning algorithm can be employed to dynamically adapt to the neural signal drifts, thereby maintaining high accuracy without external intervention. This work proposes S…
Sri Sivasubramaniya Nadar College of Engineering（斯里西瓦苏布拉马尼亚纳达尔工程学院）
Neonatal seizures are a commonly encountered neurological condition. They are the first clinical signs of a serious neurological disorder. Thus, rapid recognition and treatment are necessary to prevent serious fatalities. The use of electroencephalography (EEG) in the field of neurology allows precise diagnosis of several medical conditions. However, interpreting EEG signals needs the attention of highly specialized staff since the infant brain is developmentally immature during the neonatal period. Detecting seizures on time could potentially prevent the negative effects on the neurocognitive…
Indian Institute of Information Technology, Sonepat（印度信息技术学院，索尼帕特）；National Institute of Technology, Kurukshetra（国立技术学院，库鲁克舍特拉）；Punjab Agricultural University（旁遮普农业大学）
Timely diagnosis is important for saving the life of epileptic patients. In past few years, a lot of treatments are available for epilepsy. These treatments require use of anti-seizure drugs but are not effective in controlling frequency of seizure. There is need of removal of an affected region using surgery. Electroencephalogram (EEG) is a widely used technique for monitoring the brain activity and widely popular for seizure region detection. It is used before surgery for locating affected region. This manual process, using EEG graphs, is time consuming and requires deep expertise. In the pr…
Electroencephalography (EEG) analysis extracts critical information from brain signals, which has provided fundamental support for various applications, including brain-disease diagnosis and brain-computer interface. However, the real-time processing of large-scale EEG signals at high energy efficiency has placed great challenges for electronic processors on edge computing devices. Here, we propose the EEG opto-processor based on diffractive photonic computing units (DPUs) to effectively process the extracranial and intracranial EEG signals and perform epileptic seizure detection. The signals …
Epilepsy affects about 1% of the population every year, and is characterized by abnormal and sudden hyper-synchronous excitation of the neurons in the brain. The electroencephalogram(EEG) is the most widely used method to record brain signals and diagnose epilepsy and seizure cases. In this paper we use the method of Variational Mode Decomposition (VMD) in our analysis to classify seizure/seizure free signals. This technique uses variational non recursive mode decomposition, in comparison to other methods like Empirical Mode (EMD) and Hilbert-Huang transform which recursively decompose the sig…
ETH Zurich（苏黎世联邦理工学院）；Inselspital Bern（伯尔尼 Inselspital 医院）
This paper presents an efficient binarized algorithm for both learning and classification of human epileptic seizures from intracranial electroencephalography (iEEG). The algorithm combines local binary patterns with brain-inspired hyperdimensional computing to enable end-to-end learning and inference with binary operations. The algorithm first transforms iEEG time series from each electrode into local binary pattern codes. Then atomic high-dimensional binary vectors are used to construct composite representations of seizures across all electrodes. For the majority of our patients (10 out of 1…
K. N. Toosi University of Technology（K. N. 图西理工大学）；Ferdowsi University of Mashhad（马什哈德菲尔多西大学）；Semnan University（塞姆南大学）；Deakin University（迪肯大学）；University of California, San Francisco（加州大学旧金山分校）
A variety of screening approaches have been proposed to diagnose epileptic seizures, using electroencephalography (EEG) and magnetic resonance imaging (MRI) modalities. Artificial intelligence encompasses a variety of areas, and one of its branches is deep learning (DL). Before the rise of DL, conventional machine learning algorithms involving feature extraction were performed. This limited their performance to the ability of those handcrafting the features. However, in DL, the extraction of features and classification are entirely automated. The advent of these techniques in many areas of med…
Technion - Israel Institute of Technology（以色列理工学院）；The Hospital for Sick Children（病童医院）；University of Toronto（多伦多大学）；KU Leuven（鲁汶大学）；Alberta Children’s Hospital（阿尔伯塔儿童医院）；University of Calgary（卡尔加里大学）；Li Ka Shing Knowledge Institute of St. Michael’s Hospital（圣迈克尔医院李嘉诚知识研究院）
Objective: Epileptic seizures are relatively common in critically-ill children admitted to the pediatric intensive care unit (PICU) and thus serve as an important target for identification and treatment. Most of these seizures have no discernible clinical manifestation but still have a significant impact on morbidity and mortality. Children that are deemed at risk for seizures within the PICU are monitored using continuous-electroencephalogram (cEEG). cEEG monitoring cost is considerable and as the number of available machines is always limited, clinicians need to resort to triaging patients a…
Epilepsy is the second most common brain disorder after migraine. Automatic detection of epileptic seizures can considerably improve the patients' quality of life. Current Electroencephalogram (EEG)-based seizure detection systems encounter many challenges in real-life situations. The EEGs are non-stationary signals and seizure patterns vary across patients and recording sessions. Moreover, EEG data are prone to numerous noise types that negatively affect the detection accuracy of epileptic seizures. To address these challenges, we introduce the use of a deep learning-based approach that autom…
Objective: The detection of epileptic seizures from scalp electroencephalogram (EEG) signals can facilitate early diagnosis and treatment. Previous studies suggested that the Gaussianity of EEG distributions changes depending on the presence or absence of seizures; however, no general EEG signal models can explain such changes in distributions within a unified scheme. Methods: This paper describes the formulation of a stochastic EEG model based on a multivariate scale mixture distribution that can represent changes in non-Gaussianity caused by stochastic fluctuations in EEG. In addition, we pr…
Epilepsy Seizure Detection and Prediction using an Approximate Spiking Convolutional Transformer
Institute of Neuroinformatics, University of Zurich and ETH Zurich（苏黎世大学与苏黎世联邦理工学院神经信息学研究所）；Delft University of Technology（代尔夫特理工大学）；School of Electronic Science and Technology, Nanjing University（南京大学电子科学与技术学院）
In this paper, the wavelet analysis is used to study the ECG signal. We show that the high-frequency wavelet components of the ECG signal contain information on the functioning of the heart and can be used in diagnosis. We describe the automated classification system that separates the ECG of sick and healthy persons using only a high-frequency ECG component.
Reduced system dependability and higher maintenance costs may be the consequence of poor electric power quality, which can disturb normal equipment performance, speed up aging, and even cause outright failures. This study implements and tests a prototype of an Online Sequential Extreme Learning Machine (OS-ELM) classifier based on wavelets for detecting power quality problems under transient conditions. In order to create the classifier, the OSELM-network model and the discrete wavelet transform (DWT) method are combined. First, discrete wavelet transform (DWT) multi-resolution analysis (MRA) …
In this paper a technique for detection of multiple power quality (PQ) events is illustrated. An algorithm based on wavelet transform and Random Forest based classifier is proposed in this paper. The developed technique is implemented on 11 different power quality events consisting of single stage power quality events such as sag, swell, flicker, interruption and multi stage power quality events such as harmonics combined with sag, swell, flicker, interruption. PQ events are simulated in MATLAB using standard IEEE-1159 standard. Significant features of PQ events are extracted using wavelet tra…
