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scInterpreter:训练大语言模型解读单细胞RNA测序数据以实现细胞类型注释

scInterpreter: Training Large Language Models to Interpret scRNA-seq Data for Cell Type Annotation

Computer Network Information Center, Chinese Academy of Sciences(中国科学院计算机网络信息中心);State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences(中国科学院动物研究所干细胞与生殖生物学国家重点实验室);University of Chinese Academy of Sciences(中国科学院大学)

Cong Li, Meng Xiao, Pengfei Wang, Guihai Feng, Xin Li, Yuanchun Zhou

AI总结:

本文提出scInterpreter,训练大语言模型解读单细胞RNA测序数据,初步实验表明其能准确分类已知细胞类型,有望成为发现新生物学见解的有效工具。

摘要:

尽管现有大语言模型在直接读取和解读单细胞组学数据方面存在固有限制,但它们作为基础模型展现出显著的潜力和灵活性。本研究聚焦于如何训练和适配大语言模型,使其具备解读和区分单细胞RNA测序数据中细胞类型的能力。我们的初步研究结果表明,这些基础模型在准确分类已知细胞类型方面表现出色,展示了大语言模型作为揭示新生物学见解的有效工具的潜力。

英文摘要:

Despite the inherent limitations of existing Large Language Models in directly reading and interpreting single-cell omics data, they demonstrate significant potential and flexibility as the Foundation Model. This research focuses on how to train and adapt the Large Language Model with the capability to interpret and distinguish cell types in single-cell RNA sequencing data. Our preliminary research results indicate that these foundational models excel in accurately categorizing known cell types, demonstrating the potential of the Large Language Models as effective tools for uncovering new biological insights.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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