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arXiv 2402.01191cs.CV
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基于扩散模型从MRI无监督生成伪正常PET用于癫痫灶定位

Unsupervised Generation of Pseudo Normal PET from MRI with Diffusion Model for Epileptic Focus Localization

University of Michigan-Shanghai Jiao Tong University Joint Institute(上海交通大学密西根学院);School of Biomedical Engineering, Shanghai Jiao Tong University(上海交通大学生物医学工程学院);Global Institute of Future Technology, Shanghai Jiao Tong University(上海交通大学未来技术学院);Ruijin Hospital, Shanghai Jiao Tong University School of Medicine(上海交通大学医学院附属瑞金医院)

Wentao Chen, Jiwei Li, Xichen Xu, Hui Huang, Siyu Yuan, Miao Zhang, Tianming Xu, Jie Luo, Weimin Zhou

AI总结:

针对健康对照PET数据难以获取的问题,本研究采用无监督学习方法实现非配对MRI到PET的转换,生成伪正常FDG PET用于癫痫灶定位,验证了扩散方法的更优定位性能。

摘要:

[$^{18}$F]氟代脱氧葡萄糖(FDG)正电子发射断层扫描(PET)已成为识别癫痫灶的关键工具,尤其是在磁共振成像(MRI)诊断结果不明确的病例中。FDG PET可提供葡萄糖代谢信息,帮助识别通过MRI难以发现的异常区域。然而,基于FDG PET的评估与诊断效果取决于健康对照组的选择。健康对照组通常由在年龄、性别及其他方面与癫痫患者相似的健康个体组成,用于提供正常FDG PET数据,作为提升癫痫诊断准确性与可靠性的参考。但当无法获取健康PET对照组时,会面临重大挑战。Yaakub等人此前提出了一种基于Pix2PixGAN的MRI到PET转换方法,该方法使用健康个体的配对MRI与FDG PET扫描数据进行训练,从患者MRI生成伪正常FDG PET图像,随后用于病灶检测。然而,这种方法需要大量来自健康对照受试者的高质量配对MRI与PET图像,而这类数据并非总能获取。本研究探究了用于非配对MRI到PET转换的无监督学习方法,以生成用于癫痫灶定位的伪正常FDG PET。研究采用了CycleGAN与SynDiff两种深度学习方法,结果发现基于扩散的方法在精准定位癫痫灶方面实现了更优的性能。

英文摘要:

[$^{18}$F]fluorodeoxyglucose (FDG) positron emission tomography (PET) has emerged as a crucial tool in identifying the epileptic focus, especially in cases where magnetic resonance imaging (MRI) diagnosis yields indeterminate results. FDG PET can provide the metabolic information of glucose and help identify abnormal areas that are not easily found through MRI. However, the effectiveness of FDG PET-based assessment and diagnosis depends on the selection of a healthy control group. The healthy control group typically consists of healthy individuals similar to epilepsy patients in terms of age, gender, and other aspects for providing normal FDG PET data, which will be used as a reference for enhancing the accuracy and reliability of the epilepsy diagnosis. However, significant challenges arise when a healthy PET control group is unattainable. Yaakub \emph{et al.} have previously introduced a Pix2PixGAN-based method for MRI to PET translation. This method used paired MRI and FDG PET scans from healthy individuals for training, and produced pseudo normal FDG PET images from patient MRIs that are subsequently used for lesion detection. However, this approach requires a large amount of high-quality, paired MRI and PET images from healthy control subjects, which may not always be available. In this study, we investigated unsupervised learning methods for unpaired MRI to PET translation for generating pseudo normal FDG PET for epileptic focus localization. Two deep learning methods, CycleGAN and SynDiff, were employed, and we found that diffusion-based method achieved improved performance in accurately localizing the epileptic focus.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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