Integrating Physician Diagnostic Logic into Large Language Models: Preference Learning from Process Feedback
School of Computer Science, Peking University(北京大学计算机学院);Key Laboratory of High Confidence Software Technologies(PKU), MOE, China(教育部高可信软件技术重点实验室);Beijing Jiaotong University(北京交通大学)
The use of large language models in medical dialogue generation has garnered significant attention, with a focus on improving response quality and fluency. While previous studies have made progress in optimizing model performance for single-round medical Q&A tasks, there is a need to enhance the model's capability for multi-round conversations to avoid logical inconsistencies. To address this, we propose an approach called preference learning from process feedback~(PLPF), which integrates the doctor's diagnostic logic into LLMs. PLPF involves rule modeling, preference data generation, and preference alignment to train the model to adhere to the diagnostic process. Experimental results using Standardized Patient Testing show that PLPF enhances the diagnostic accuracy of the baseline model in medical conversations by 17.6%, outperforming traditional reinforcement learning from human feedback. Additionally, PLPF demonstrates effectiveness in both multi-round and single-round dialogue tasks, showcasing its potential for improving medical dialogue generation.
Comparisons between a Large Language Model-based Real-Time Compound Diagnostic Medical AI Interface and Physicians for Common Internal Medicine Cases using Simulated Patients
Shihwa Medical Center(始华医疗中心);Helpmedoc Inc.(Helpmedoc公司);Asan Medical Center(峨山医疗中心);University of Ulsan College of Medicine(蔚山大学医学院)
本研究开发了基于大语言模型的实时复合诊断医疗AI界面,通过非随机临床试验与医生比较,发现其在常见内科病例中诊断准确率更高(80% vs 50-70%)、时间更短(缩短44.6%)、成本更低(降低98.1%),患者满意度相当,显示出辅助初级保健的潜力。
Reverse Physician-AI Relationship: Full-process Clinical Diagnosis Driven by a Large Language Model
State Key Laboratory of AI Safety, Institute of Computing Technology, CAS(人工智能安全国家重点实验室,计算技术研究所,中国科学院);University of Chinese Academy of Sciences(中国科学院大学);Peking University Third Hospital(北京大学第三医院)
Superhuman performance of a large language model on the reasoning tasks of a physician
Beth Israel Deaconess Medical Center(贝斯以色列女执事医疗中心);Harvard Medical School(哈佛医学院);Stanford University(斯坦福大学);Cambridge Health Alliance(剑桥健康联盟);Brigham and Women's Hospital(布列根和妇女医院);University of Minnesota Medical School(明尼苏达大学医学院);University of Maryland School of Medicine(马里兰大学医学院);Veterans Affairs Maryland Healthcare System(马里兰退伍军人医疗保健系统);VA Palo Alto Health Care System(帕洛阿尔托退伍军人医疗保健系统);Massachusetts Institute of Technology(麻省理工学院);University of Alberta(阿尔伯塔大学);Beth Israel Lahey Health(贝斯以色列拉海健康);Massachusetts General Hospital(麻省总医院);Microsoft Corp(微软公司)
Exploring LLM-based Data Annotation Strategies for Medical Dialogue Preference Alignment
School of Computer Science, Peking University(北京大学计算机学院);Key Laboratory of High Confidence Software Technologies(PKU), MOE, China(教育部高可信软件技术重点实验室(北京大学));Beijing Jiaotong University(北京交通大学)
Large Language Models Versus Physicians in Traditional Chinese Medicine: A Real-World Clinical Case Evaluation
University of Missouri(密苏里大学);Community Health Service Center Shanghai Pudong New Area(上海市浦东新区社区卫生服务中心);Jinsha County Chinese Medicine Hospital(金沙县中医院);Shanghai Seventh People's Hospital(上海市第七人民医院);The First People’s Hospital of Lanzhou City(兰州市第一人民医院);The First Affiliated Hospital of Yunnan University of Chinese Medicine(云南中医药大学第一附属医院);Northwestern University(西北大学);Linyi Traditional Chinese Medicine Hospital(临沂市中医院);Shanghai University of Traditional Chinese Medicine(上海中医药大学)
From Physician Expertise to Clinical Agents: Preserving, Standardizing, and Scaling Physicians' Medical Expertise with Lightweight LLM
the School of Chinese Medicine, the Beijing University of Chinese Medicine, Beijing, China(中国中医药大学中医学院,北京中医药大学,北京,中国);the School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China(南京中医药大学药学院,南京,中国);the Infectious disease department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China(北京中医药大学东四医院感染科,北京,中国);the Gulou Hospital of Traditional Chinese Medicine of Beijing,Beijing, China(北京中医药大学附属鼓楼中医医院,北京,中国);the Department of Computer Science, Johns Hopkins University, Baltimore, USA(约翰霍普金斯大学计算机科学系,美国马里兰州巴尔的摩市);the Department of Education, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China(北京中医药大学东直门医院教育部,北京,中国);the Department of Pediatrics, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China(中国医学科学院北京协和医院儿科部,北京,中国);the School of Information Engineering, Huzhou University, Huzhou, China(湖州大学信息工程学院,湖州,中国);Research Center for Scientific Data Hub, Zhejiang Lab, Hangzhou, China(浙江省实验室科学数据中心研究中心,杭州,中国);the Frontier Basic Research Center, Zhejiang Lab, Hangzhou, China(浙江省实验室前沿基础研究中心,杭州,中国);the Research Center for High Efficiency Computing Infrastructure, Zhejiang Lab, Hangzhou, China(浙江省实验室高效计算基础设施研究中心,杭州,中国)
RareBench: Can LLMs Serve as Rare Diseases Specialists?
Tsinghua University(清华大学);Peking Union Medical College Hospital(北京协和医院);Chinese Academy of Medical Sciences(中国医学科学院);Peking Union Medical College(北京协和医学院)
RPRO: Ranked Preference Reinforcement Optimization for Enhancing Medical QA and Diagnostic Reasoning
Department of Computer Science and Information Engineering, National Taiwan University of Science and Technology(计算机科学与信息工程系,台湾科技大学);Department of Systems Engineering, Stevens Institute of Technology(系统工程系,史蒂文斯理工学院);Department of Management Information Systems, National Chengchi University(管理信息系,National Chengchi University);AI Research Center, Agaruda System(Agaruda系统人工智能研究中心);Department of Computer Science, Stevens Institute of Technology(计算机科学系,史蒂文斯理工学院);Far Eastern Memorial Hospital(东部纪念医院);Smart Healthcare Interdisciplinary College, National Taipei University of Nursing and Health Sciences(智慧医疗跨领域学院,台北大学护理及健康科学学院)
Leveraging Large Language Models to Extract and Translate Medical Information in Doctors' Notes for Health Records and Diagnostic Billing Codes
Department of Computer Science & Information Technologies, Frostburg State University(弗罗斯堡州立大学计算机科学与信息科技系);Department of Emergency Medicine, FAU Charles E Schmidt College of Medicine(FAU查尔斯·E·施密特医学院急诊医学系)
Automatic Personalized Impression Generation for PET Reports Using Large Language Models
University of Wisconsin(威斯康星大学);Emory University School of Medicine(埃默里大学医学院);Children’s Healthcare of Atlanta(亚特兰大儿童医疗保健系统);Roswell Park Comprehensive Cancer Center(罗斯韦尔公园综合癌症中心);University at Buffalo Jacobs School of Medicine and Biomedical Sciences(布法罗大学雅各布斯医学与生物医学科学学院)
A specialized reasoning large language model for accelerating rare disease diagnosis: a randomized AI physician assistance trial
Tsinghua Medicine, Tsinghua University(清华大学医学部,清华大学);Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College(北京大学人民医院眼科,中国医学科学院 & 北京大学医学部);Department of Statistics and Data Science, Tsinghua University(清华大学统计与数据科学系);Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College(北京大学人民医院风湿免疫科,中国医学科学院 & 北京大学医学部);Department of Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College(北京大学人民医院罕见病科,中国医学科学院 & 北京大学医学部);Department of Dermatology, Xijing Hospital, Air Force Medical University(西安空军军医大学西京医院皮肤科);School of Computer Science and Technology, East China Normal University (ECNU)(东华大学计算机科学与技术学院);Department of Neurosurgery, Xuanwu Hospital, Capital Medical University(首都医科大学宣武医院神经外科);Department of Ophthalmology, National University of Singapore(新加坡国立大学眼科);Singapore Eye Research Institute, Singapore National Eye Centre(新加坡眼科学研究所,新加坡国家眼科中心);Ophthalmology and Visual Science Academic Clinical Program, Duke-NUS Medical School(杜克-国立新加坡大学医学学校眼科与视觉科学学术临床项目);Department of Pediatrics, The First Hospital of Tsinghua University(清华大学第一医院儿科);College of Future Technology, Peking University(北京大学未来技术学院);School of Health and Wellbeing, University of Glasgow(格拉斯哥大学健康与福祉学院)
ClinDEF: A Dynamic Evaluation Framework for Large Language Models in Clinical Reasoning
ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University(浙江大学杭州全球科技创新中心);ZJU-UIUC Institute, Zhejiang University(浙江大学UIUC研究院);College of Computer Science and Technology, Zhejiang University(浙江大学计算机科学与技术学院);The Polytechnic Institute, Zhejiang University(浙江大学 polytechnic 院);AntGroup(蚂蚁集团)
DiReCT: Diagnostic Reasoning for Clinical Notes via Large Language Models
Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe)(人类元宇宙医学高级研究机构(WPI-PRIMe));Osaka University(大阪大学);Department of Cardiology, The First Affiliated Hospital of Dalian Medical University(大连医科大学第一附属医院心内科);Institute of Computing Technology, Chinese Academy of Science(中国科学院计算技术研究所);D3 Center, Osaka University(大阪大学D3中心);Agency for Science, Technology and Research (A*STAR)(科技研究局(A*STAR))
HEAL: A Hypothesis-Based Preference-Aware Analysis Framework
School of Computer Science and Engineering, Northeastern University(计算机科学与工程学院,东北大学);NiuTrans Research(NiuTrans研究院);CAS Key Laboratory of Behavioral Science, Institute of Psychology, CAS(行为科学重点实验室,心理学研究所)
Ask Now, Use Later: Benchmarking the Proactivity Gap in Long-Lived LLM Agents
Beijing University of Posts and Telecommunications(北京邮电大学);Nanjing University of Aeronautics and Astronautics(南京航空航天大学);Harbin Institute of Technology (Shenzhen)(哈尔滨工业大学(深圳));Noumena AI
A Super-Learner with Large Language Models for Medical Emergency Advising
Northeastern University(东北大学);Biovitalage S.R.L.(Biovitalage有限责任公司);Territorial Emergency System SET 118(地区紧急系统SET 118);Territorial Center for Medical Assistance(地区医疗援助中心);Aldo Moro University of Bari(巴里阿尔多·莫罗大学)
Improving Interactive Diagnostic Ability of a Large Language Model Agent Through Clinical Experience Learning
Research Center of Computational Life Science, Zhejiang Lab(浙江实验室计算生命科学研究中心);TransTek Medical(TransTek医疗);Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University(浙江大学医学院附属邵逸夫医院);College of Computer Science and Technology, Zhejiang University(浙江大学计算机科学与技术学院)
End-to-End Agentic RAG System Training for Traceable Diagnostic Reasoning
Shanghai Jiao Tong University(上海交通大学);Shanghai AI Laboratory(上海人工智能实验室);Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine(上海交通大学医学院附属新华医院);Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine(上海交通大学医学院附属第九人民医院);Shanghai Jiao Tong University School of Medicine(上海交通大学医学院)
Beyond Uniform Forgetting: A Study of Sequential Direct Preference Optimization Across Preference Settings
Network Analysis and Social Influence Modelling (NASIM) Lab(网络分析与社会影响建模实验室);School of Physics Maths and Computing, The University of Western Australia(西澳大学物理数学与计算学院);School of Psychological Science, The University of Western Australia(西澳大学心理科学学院);School of Computing, Macquarie University(麦考瑞大学计算机学院)
University of Toronto(多伦多大学);Vector Institute for Artificial Intelligence(矢量人工智能研究所);Unity Health Toronto(多伦多统一健康)
We introduce Doctor XAvIer, a BERT-based diagnostic system that extracts relevant clinical data from transcribed patient-doctor dialogues and explains predictions using feature attribution methods. We present a novel performance plot and evaluation metric for feature attribution methods: Feature Attribution Dropping (FAD) curve and its Normalized Area Under the Curve (N-AUC). FAD curve analysis shows that integrated gradients outperforms Shapley values in explaining diagnosis classification. Doctor XAvIer outperforms the baseline with 0.97 F1-score in named entity recognition and symptom perti…
AI-generated data contamination erodes pathological variability and diagnostic reliability
National University of Singapore(新加坡国立大学);Harvard University(哈佛大学);Massachusetts General Hospital(麻省总医院);Stanford University(斯坦福大学);Yale University(耶鲁大学);Google(谷歌);Mayo Clinic(妙佑医疗国际)