具有平面外聚焦光栅发射器的可植入光子神经探针
Implantable Photonic Neural Probes with Out-of-Plane Focusing Grating Emitters
AI总结：
该研究设计制造了带纳米光子光栅发射器的可植入硅神经探针，利用全息原理实现指定距离光聚焦，匹配光遗传学执行器光谱，实测与模拟吻合，首次实现脑组织中神经元胞体尺寸级聚焦光斑。
摘要：
我们设计、制造并表征了带有纳米光子光栅发射器的可植入硅神经探针，该发射器能将发射光聚焦在探针表面上方的指定距离处，以实现对神经元的空间精确光遗传学靶向。利用全息原理，我们为488 nm和594 nm波长设计了光栅，分别靶向光遗传学执行器Channelrhodopsin-2（通道视紫红质-2）和Chrimson的激发光谱。这些发射器在非散射介质和组织中的实测光发射模式与模拟结果吻合良好。据我们所知，这是首次报道由可植入神经探针在脑组织中形成神经元胞体尺寸级聚焦光斑的研究。
英文摘要：
We have designed, fabricated, and characterized implantable silicon neural probes with nanophotonic grating emitters that focus the emitted light at a specified distance above the surface of the probe for spatially precise optogenetic targeting of neurons. Using the holographic principle, we designed gratings for wavelengths of 488 and 594 nm, targeting the excitation spectra of the optogenetic actuators Channelrhodopsin-2 and Chrimson, respectively. The measured optical emission pattern of these emitters in non-scattering medium and tissue matched well with simulations. To our knowledge, this is the first report of focused spots with the size scale of a neuron soma in brain tissue formed from implantable neural probes.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
