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多囊肾病的深度学习:利用神经网络通过基因表达分析实现准确早期检测

Deep Learning for Polycystic Kidney Disease: Utilizing Neural Networks for Accurate and Early Detection through Gene Expression Analysis

University of North Texas(北德克萨斯大学)

Kapil Panda, Anirudh Mazumder

AI总结:

本研究提出基于深度学习的基因表达分析方法,用于多囊肾病的准确早期检测,并通过基因本体论分析揭示PKD可能影响的关键基因过程与功能。

摘要:

多囊肾病(PKD)可能因肾脏中囊肿的形成而导致患者出现致命并发症,因此PKD的早期检测对于有效管理该疾病至关重要。然而,在诊断中起作用的多种患者特异性因素使临床医生难以解决这一复杂难题,并可能导致肾衰竭。因此,在本研究中,我们旨在利用基于深度学习的方法,通过基因表达分析实现早期疾病检测。所设计的神经网络能够对肾脏中可能的PKD实现准确且稳健的预测结果,从而改善患者预后。此外,通过进行基因本体论(Gene Ontology)分析,我们能够预测PKD可能影响的顶级基因过程和功能。

英文摘要:

With Polycystic Kidney Disease (PKD) potentially leading to fatal complications in patients due to the formation of cysts in kidneys, early detection of PKD is crucial for effective management of the condition. However, the various patient-specific factors that play a role in the diagnosis make it an intricate puzzle for clinicians to solve, leading to possible kidney failure. Therefore, in this study we aim to utilize a deep learning-based approach for early disease detection through gene expression analysis. The devised neural network is able to achieve accurate and robust prediction results for possible PKD in kidneys, thereby improving patient outcomes. Furthermore, by conducting a gene ontology analysis, we were able to predict the top gene processes and functions that PKD may affect.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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