等效时间主动空化成像实现血管分辨率血脑屏障开放治疗规划

Intravital imaging and cavitation monitoring of antivascular ultrasound in tumor microvasculature

Focused ultrasound stimulated microbubbles have been shown to be capable of inducing blood flow shutdown and necrosis in a range of tissue types in an approach termed antivascular ultrasound or mechanical ablation. In oncology, this approach has demonstrated tumor growth inhibition, and profound synergistic antitumor effects when combined with traditional platforms of chemo, radiation and immune therapies. However, the exposure schemes employed have been broad and underlying mechanisms remain unclear with fundamental questions about exposures, vessel types and sizes involved, and the nature of…

Delivery of Liquid Metal to the Target Vessels as Vascular Embolic Agent to Starve Diseased Tissues or Tumors to Death

Tumor growth relies heavily on the continuous blood and nutrients supply. Theoretically, it is an ideal therapeutic way of killing tumor by only vascular embolization. However, most of the existing vascular embolic agents are still rather insufficient to fulfill the real clinical need due to the reasons like: incomplete filling of target vasculature, being easily washed away by blood or body solution, or just producing toxicity to tissues. Here from an alternative way, the body temperature liquid metal, a kind of soft and highly compliant material, was proposed for the first time as blood vess…

一种用于治疗血管闭塞的新型前视超声导管

A novel forward-looking ultrasound catheter for treating vascular occlusions

本研究开发了一种带径向极化空心圆柱换能器的新型前视超声导管，可容纳导丝并递送空化核与药物，经实验验证能产生足够前视声压并激发惯性空化，为血管闭塞治疗提供新方案。

使用互相关角谱法的高质量被动声成像

High-Quality Passive Acoustic Mapping with the Cross-Correlated Angular Spectrum Method

针对PAM实时性与图像质量难以兼顾的问题，提出AS-TAX方法，通过子孔径AS波场互相关抑制伪影，以低两个数量级的计算量实现高质量毫秒级空化成像。

Wideband Excitation of Microbubbles with Chirps to Maximize the Sonoporation Efficiency and Contrast in Ultrasound Imaging

The importance of the excitation bandwidth is well known in diagnostic ultrasound imaging. However, the effect of excitation bandwidth in therapeutic applications of microbubbles has been mostly overlooked. A majority of contrast agent production techniques generate polydisperse microbubble populations, so a wide range of resonance frequencies exist. Therefore, wideband excitation is necessary to fully utilize microbubble resonance behavior and maximize the reradiated energy from a microbubble population, both for imaging and therapy. Oscillations of sixty SonoVue microbubbles in proximity of …

小鼠肿瘤中 radon-220 扩散的首次测量：迈向扩散 α 发射体放射治疗中的治疗规划

First measurements of radon-220 diffusion in mice tumors, towards treatment planning in diffusing alpha-emitters radiation therapy

本研究通过 24 个小鼠皮下肿瘤的放射自显影测量，首次实验估计 Alpha-DaRT 中 radon-220 的扩散长度，并发现体内远处活度扩散可能与血管贡献有关。