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arXiv 2305.07992cs.ITmath.IT
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论 DNA 标记的容量

On the Capacity of DNA Labeling

Dganit Hanania, Daniella Bar-Lev, Yevgeni Nogin, Yoav Shechtman, Eitan Yaakobi

AI总结:

本文研究 DNA 标记成像模型的最大信息率,计算单一标记容量,给出多标记结果,并确定达到容量 2 所需长度 1 或 2 标记的最小数量。

摘要:

DNA 标记是分子生物学和生物技术中的一种强大工具,可在分子水平上实现 DNA 的可视化、检测与研究。在该范式下,一个 DNA 分子由特定的 k 种模式进行标记,随后被成像。所得图像被建模为一个 (k+1) 元序列,其中任何非零符号都表示相应标记在 DNA 分子中的出现。本工作的主要目标是研究标记容量,其定义为利用该标记过程能够获得的最大信息率。文中计算了任意单一标记的标记容量,并针对多种标记给出了若干结果。此外,我们还给出了为获得标记容量 2 所需的、长度为 1 或 2 的标记的最优最小数量。

英文摘要:

DNA labeling is a powerful tool in molecular biology and biotechnology that allows for the visualization, detection, and study of DNA at the molecular level. Under this paradigm, a DNA molecule is being labeled by specific k patterns and is then imaged. Then, the resulted image is modeled as a (k + 1)- ary sequence in which any non-zero symbol indicates on the appearance of the corresponding label in the DNA molecule. The primary goal of this work is to study the labeling capacity, which is defined as the maximal information rate that can be obtained using this labeling process. The labeling capacity is computed for any single label and several results are provided for multiple labels as well. Moreover, we provide the optimal minimal number of labels of length one or two that are needed in order to gain labeling capacity of 2.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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