arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2305.03340q-bio.PEcs.AIcs.SYeess.SYphysics.bio-ph
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用于控制进化与生态过程的强化学习

Reinforcement Learning for Control of Evolutionary and Ecological Processes

Mathematical Medicine Group, Stanford University(斯坦福大学数学医学组);Department of Neurosurgery, Stanford Medical School(斯坦福医学院神经外科部门);Physician-Scientist Training Program, Stanford Medical School(斯坦福医学院医师-科学家培训计划);Maternal & Child Health Research Institute, Stanford University School of Medicine(斯坦福大学医学院母婴健康研究所);Stanford Cancer Institute, Stanford University School of Medicine(斯坦福大学医学院癌症研究所)

Bryce Allen Bagley, Navin Khoshnan, Claudia K Petritsch

AI总结:

针对现有方法难以处理含生态、生理因素的进化控制问题,研究提出将二者建模为计算的进化博弈公式,结合强化学习取得细胞种群进化控制的首创成果,证明复杂度界并建立AI与生物学新联系。

摘要:

随着进化动力学从理论领域走向应用,需要算法来突破简单模型的局限,但现有文献中这类方法极少。已知生态和生理因素是现实情境下进化的核心,但纳入这些因素通常会让现有方法难以处理相关问题。我们提出一种进化博弈公式,通过将生态和生理建模为计算过程来纳入二者,并以此借助强化学习方法分析定向进化问题。这种结合让我们在学习控制不断进化的细胞种群的算法问题上取得了首创性成果。我们证明了在对细胞生理或生态的先验知识有限的情况下,生态进化控制的复杂度界,给出了最一般版本定向进化数学问题的首批结果,并建立了AI与生物学之间的新联系。

英文摘要:

As Evolutionary Dynamics moves from the realm of theory into application, algorithms are needed to move beyond simple models. Yet few such methods exist in the literature. Ecological and physiological factors are known to be central to evolution in realistic contexts, but accounting for them generally renders problems intractable to existing methods. We introduce a formulation of evolutionary games which accounts for ecology and physiology by modeling both as computations and use this to analyze the problem of directed evolution via methods from Reinforcement Learning. This combination enables us to develop first-of-their-kind results on the algorithmic problem of learning to control an evolving population of cells. We prove a complexity bound on eco-evolutionary control in situations with limited prior knowledge of cellular physiology or ecology, give the first results on the most general version of the mathematical problem of directed evolution, and establish a new link between AI and biology.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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