MRI synthesis promises to mitigate the challenge of missing MRI modality in clinical practice. Diffusion model has emerged as an effective technique for image synthesis by modelling complex and variable data distributions. However, most diffusion-based MRI synthesis models are using a single modality. As they operate in the original image domain, they are memory-intensive and less feasible for multi-modal synthesis. Moreover, they often fail to preserve the anatomical structure in MRI. Further, balancing the multiple conditions from multi-modal MRI inputs is crucial for multi-modal synthesis. Here, we propose the first diffusion-based multi-modality MRI synthesis model, namely Conditioned Latent Diffusion Model (CoLa-Diff). To reduce memory consumption, we design CoLa-Diff to operate in the latent space. We propose a novel network architecture, e.g., similar cooperative filtering, to solve the possible compression and noise in latent space. To better maintain the anatomical structure, brain region masks are introduced as the priors of density distributions to guide diffusion process. We further present auto-weight adaptation to employ multi-modal information effectively. Our experiments demonstrate that CoLa-Diff outperforms other state-of-the-art MRI synthesis methods, promising to serve as an effective tool for multi-modal MRI synthesis.
Magnetic resonance imaging (MRI) is a common and life-saving medical imaging technique. However, acquiring high signal-to-noise ratio MRI scans requires long scan times, resulting in increased costs and patient discomfort, and decreased throughput. Thus, there is great interest in denoising MRI scans, especially for the subtype of diffusion MRI scans that are severely SNR-limited. While most prior MRI denoising methods are supervised in nature, acquiring supervised training datasets for the multitude of anatomies, MRI scanners, and scan parameters proves impractical. Here, we propose Denoising…
Patch-Based Diffusion for Data-Efficient, Radiologist-Preferred MRI Reconstruction
Stanford University（斯坦福大学）；Stanford University School of Medicine（斯坦福大学医学院）；Stanford Center for Artificial Intelligence in Medicine and Imaging（斯坦福大学医学与成像人工智能中心）；Georgia Institute of Technology（佐治亚理工学院）
Cycle-guided Denoising Diffusion Probability Model for 3D Cross-modality MRI Synthesis
Emory University（埃默里大学）；Winship Cancer Institute（温希普癌症研究所）；Memorial Sloan Kettering Cancer Center（纪念斯隆凯特琳癌症中心）；Icahn School of Medicine at Mount Sinai（西奈山伊坎医学院）
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；Inner Mongolia University（内蒙古大学）
Recently, score-based diffusion models have shown satisfactory performance in MRI reconstruction. Most of these methods require a large amount of fully sampled MRI data as a training set, which, sometimes, is difficult to acquire in practice. This paper proposes a fully-sampled-data-free score-based diffusion model for MRI reconstruction, which learns the fully sampled MR image prior in a self-supervised manner on undersampled data. Specifically, we first infer the fully sampled MR image distribution from the undersampled data by Bayesian deep learning, then perturb the data distribution and a…
Sun Yat-Sen University（中山大学）；University of Edinburgh（爱丁堡大学）；Cardiovascular Research Centre, Royal Brompton Hospital（皇家布朗普顿医院心血管研究中心）；National Heart & Lung Institute, Imperial College London（帝国理工学院国家心肺研究所）
The performance of traditional compressive sensing-based MRI (CS-MRI) reconstruction is affected by its slow iterative procedure and noise-induced artefacts. Although many deep learning-based CS-MRI methods have been proposed to mitigate the problems of traditional methods, they have not been able to achieve more robust results at higher acceleration factors. Most of the deep learning-based CS-MRI methods still can not fully mine the information from the k-space, which leads to unsatisfactory results in the MRI reconstruction. In this study, we propose a new deep learning-based CS-MRI reconstr…
LDPM: Towards undersampled MRI reconstruction with MR-VAE and Latent Diffusion Prior
Shenzhen Technology University（深圳科技大学）；Shenzhen University（深圳大学）；Huawei（华为）；Nanjing University of Science and Technology（南京理工大学）；Qilu University of Technology（齐鲁工业大学）
Non-rigid Motion Correction for MRI Reconstruction via Coarse-To-Fine Diffusion Models
Department of Computing and Mathematical Sciences, Caltech（计算与数学科学部，加利福尼亚理工学院）；Chandra Family Department of Electrical and Computer Engineering, UT Austin（查纳德家庭电子与计算机工程系，德克萨斯大学奥斯汀分校）
本文提出一种基于由粗到细扩散模型的交替最小化框架，通过优先重建低频分量来联合校正非刚性运动并重建欠采样 k 空间数据，在 64 倍欠采样下仍表现良好。
MRI and CT are most widely used medical imaging modalities. It is often necessary to acquire multi-modality images for diagnosis and treatment such as radiotherapy planning. However, multi-modality imaging is not only costly but also introduces misalignment between MRI and CT images. To address this challenge, computational conversion is a viable approach between MRI and CT images, especially from MRI to CT images. In this paper, we propose to use an emerging deep learning framework called diffusion and score-matching models in this context. Specifically, we adapt denoising diffusion probabili…
MRPD: Undersampled MRI reconstruction by prompting a large latent diffusion model
School of Biomedical Engineering, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC)（中国科学技术大学生命科学与医学部生物医学工程学院）；Suzhou Institute for Advance Research, USTC（中国科学技术大学苏州高等研究院）；Key Laboratory of Precision and Intelligent Chemistry, USTC（中国科学技术大学精准与智能化学重点实验室）；Key Laboratory of Intelligent Information Processing of Chinese Academy of Sciences (CAS), Institute of Computing Technology, CAS（中国科学院计算技术研究所中国科学院智能信息处理重点实验室）
Comparative Analysis of GAN and Diffusion for MRI-to-CT translation
Department of Computer Science, University of Copenhagen, Copenhagen, Denmark（哥本哈根大学计算机科学系）；Department of Oncology, Rigshospitalet, Copenhagen, Denmark（哥本哈根医院肿瘤科）
DeepFakes are synthetic videos generated by swapping a face of an original image with the face of somebody else. In this paper, we describe our work to develop general, deep learning-based models to classify DeepFake content. We propose a novel framework for using Generative Adversarial Network (GAN)-based models, we call MRI-GAN, that utilizes perceptual differences in images to detect synthesized videos. We test our MRI-GAN approach and a plain-frames-based model using the DeepFake Detection Challenge Dataset. Our plain frames-based-model achieves 91% test accuracy and a model which uses our…
Linköping University（林雪平大学）；Center for Medical Image Science and Visualization (CMIV)（医学影像科学与可视化中心（CMIV））；Lund University（隆德大学）
Diffusion magnetic resonance imaging (diffusion MRI) is a non-invasive microstructure assessment technique. Scalar measures, such as FA (fractional anisotropy) and MD (mean diffusivity), quantifying micro-structural tissue properties can be obtained using diffusion models and data processing pipelines. However, it is costly and time consuming to collect high quality diffusion data. Here, we therefore demonstrate how Generative Adversarial Networks (GANs) can be used to generate synthetic diffusion scalar measures from structural T1-weighted images in a single optimized step. Specifically, we t…
Wavelet-Fusion Diffusion Model for Multimodal Brain MRI Synthesis with Modality and Metadata Conditioning
Department of Psychology & Neuroscience, Auckland University of Technology（心理学与神经科学系，奥克兰技术大学）；Department of Psychiatry, University of Melbourne（精神病学系，墨尔本大学）
Accelerating Stroke MRI with Diffusion Probabilistic Models through Large-Scale Pre-training and Target-Specific Fine-Tuning
Chandra Family Department of Electrical and Computer Engineering（查克拉家族电气与计算机工程系）；Department of Imaging Physics（成像物理系）；Dell Medical School Department of Neurology（德莱尔医学院神经学系）；Dell Medical School Department of Neurosurgery（德莱尔医学院神经外科系）；Dell Medical School Department of Diagnostic Medicine（德莱尔医学院诊断医学系）；Oden Institute for Computational Engineering and Sciences（奥登计算工程与科学研究院）
Multimodal synthesis of MRI and tabular data with diffusion in a joint latent space via cross-attention
Fraunhofer Institute for Digital Medicine MEVIS（弗劳恩霍夫数字医学研究所MEVIS）；Leibniz Institute for Prevention Research and Epidemiology – BIPS（莱比锡预防研究与流行病学研究所 – BIPS）；Faculty of Mathematics and Computer Science, University of Bremen（不莱梅大学数学与计算机科学学院）；Faculty of Physics and Electrical Engineering, University of Bremen（不莱梅大学物理与电气工程学院）
Pseudo-MRI-Guided PET Image Reconstruction Method Based on a Diffusion Probabilistic Model
Washington University in St. Louis（圣路易斯华盛顿大学）；Yale University（耶鲁大学）；Western University（西安大略大学）；Lawson Health Research Institute（劳森健康研究所）；McGill University（麦吉尔大学）；Siemens Healthineers AG（西门子医疗保健公司）；Mallinckrodt Institute of Radiology（马林克罗特放射学研究所）
DiffCMR: Fast Cardiac MRI Reconstruction with Diffusion Probabilistic Models
The Hong Kong University of Science and Technology（香港科技大学）；Southern University of Science and Technology（南方科技大学）；HKUST Shenzhen Research Institute（香港科技大学深圳研究院）
Rician Denoising Diffusion Probabilistic Models For Sodium Breast MRI Enhancement
University of Cambridge（剑桥大学）；Universitat de Barcelona（巴塞罗那大学）；Haukeland University Hospital（豪克兰大学医院）；University of York（约克大学）；Manchester Metropolitan University（曼彻斯特城市大学）
Magnetic resonance imaging (MRI) is highly sensitive for lesion detection in the breasts. Sequences obtained with different settings can capture the specific characteristics of lesions. Such multi-parameter MRI information has been shown to improve radiologist performance in lesion classification, as well as improving the performance of artificial intelligence models in various tasks. However, obtaining multi-parameter MRI makes the examination costly in both financial and time perspectives, and there may be safety concerns for special populations, thus making acquisition of the full spectrum …
InverseSR: 3D Brain MRI Super-Resolution Using a Latent Diffusion Model
St. Francis Xavier University（圣弗朗西斯泽维尔大学）；Martinos Center for Biomedical Imaging（马蒂诺生物医学成像中心）；Massachusetts General Hospital（麻省总医院）；Nova Scotia Health Authority（新斯科舍省卫生局）；King’s College London（伦敦国王学院）；University of California, Santa Cruz（加州大学圣克鲁兹分校）
Treatment-aware Diffusion Probabilistic Model for Longitudinal MRI Generation and Diffuse Glioma Growth Prediction
Oslo University Hospital（奥斯陆大学医院）；Universitat Politècnica de València（瓦伦西亚理工大学）；Instituto Universitario de Tecnologías de la Información y Comunicaciones（信息技术与通信大学学院）
Distillation-Driven Diffusion Model for Multi-Scale MRI Super-Resolution: Make 1.5T MRI Great Again
Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；University Sorbonne Paris Nord（巴黎北索邦大学）；Jiangsu Institute of Hematology（江苏血液学研究所）；The First Affiliated Hospital of Soochow University（苏州大学附属第一医院）；Henan University of Chinese Medicine（河南中医药大学）；German Cancer Research Center（德国癌症研究中心）；Athinoula A. Martinos Centre for Biomedical Imaging（阿西努拉·A.马蒂诺斯生物医学成像中心）；Geneva University Hospital（日内瓦大学医院）；IDP Institute（IDP研究所）；University of Orleans（奥尔良大学）
Feasibility Study of a Diffusion-Based Model for Cross-Modal Generation of Knee MRI from X-ray: Integrating Radiographic Feature Information
Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；University Sorbonne Paris Nord（巴黎北大索邦大学）；German Cancer Research Center（德国癌症研究中心）；Jiangsu Institute of Hematology（江苏血液学研究所）；The First Affiliated Hospital of Soochow University（苏州大学附属第一医院）；Henan University of Chinese Medicine（河南中医药大学）；Athinoula A. Martinos Centre for Biomedical Imaging（阿西努拉·A.马蒂诺斯生物医学成像中心）；IDP Institute（IDP研究所）；University of Orleans（奥尔良大学）
Fudan University（复旦大学）；Shanghai Jiao Tong University（上海交通大学）；King’s College London（伦敦国王学院）
Left atrial (LA) segmentation from late gadolinium enhanced magnetic resonance imaging (LGE MRI) is a crucial step needed for planning the treatment of atrial fibrillation. However, automatic LA segmentation from LGE MRI is still challenging, due to the poor image quality, high variability in LA shapes, and unclear LA boundary. Though deep learning-based methods can provide promising LA segmentation results, they often generalize poorly to unseen domains, such as data from different scanners and/or sites. In this work, we collect 210 LGE MRIs from different centers with different levels of ima…
Synthesis of Contrast-Enhanced Breast MRI Using Multi-b-Value DWI-based Hierarchical Fusion Network with Attention Mechanism
Netherlands Cancer Institute (NKI)（荷兰癌症研究所）；Maastricht University（马斯特里赫特大学）；Radboud University Medical Center（拉德堡德大学医学中心）；Fondazione Universitaria A. Gemelli, IRCCS Roma（罗马A.杰梅利大学基金会IRCCS）
The Netherlands Cancer Institute（荷兰癌症研究所）；Nanjing University of Information Science and Technology（南京信息工程大学）
Multi-sequence MRIs can be necessary for reliable diagnosis in clinical practice due to the complimentary information within sequences. However, redundant information exists across sequences, which interferes with mining efficient representations by modern machine learning or deep learning models. To handle various clinical scenarios, we propose a sequence-to-sequence generation framework (Seq2Seq) for imaging-differentiation representation learning. In this study, not only do we propose arbitrary 3D/4D sequence generation within one model to generate any specified target sequence, but also we…
A Novel Deep Learning Tractography Fiber Clustering Framework for Functionally Consistent White Matter Parcellation Using Multimodal Diffusion MRI and Functional MRI
University of Electronic Science and Technology of China（电子科技大学）；Harvard Medical School（哈佛医学院）；Boston University（波士顿大学）
Exploiting Completeness Perception with Diffusion Transformer for Unified 3D MRI Synthesis
School of Engineering, University of Birmingham, UK（伯明翰大学工程学院）；William Harvey Research Institute, Queen Mary University London, UK（女王玛丽大学伦敦威廉·哈里维研究所）；Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, UK（巴特勒心脏中心，圣巴塞洛缪医院，巴特勒健康 NHS信托）；Division of Cardiology, Johns Hopkins University School of Medicine, US（约翰霍普金斯大学医学院心脏病科）
Diffusion MRI preprocessing affects ADC estimation and automatic PI-RADS v2.1 classification in bi-parametric prostate MRI
Center for Image Sciences, University Medical Center Utrecht（乌得勒支大学医学中心影像科学中心）；Department of Radiotherapy, University Medical Center Utrecht（乌得勒支大学医学中心放射治疗科）；Cerebriu（Cerebriu公司）；Department of Diagnostic Radiology, Copenhagen University Hospital Rigshospitalet（哥本哈根大学医院 Rigshospitalet 诊断放射科）；Department of Diagnostic Radiology, Copenhagen University Hospital Herlev and Gentofte（哥本哈根大学医院海尔鲁夫与根措夫特医院诊断放射科）
Early prediction of pathological complete response (pCR) following neoadjuvant chemotherapy (NAC) for breast cancer plays a critical role in surgical planning and optimizing treatment strategies. Recently, machine and deep-learning based methods were suggested for early pCR prediction from multi-parametric MRI (mp-MRI) data including dynamic contrast-enhanced MRI and diffusion-weighted MRI (DWI) with moderate success. We introduce PD-DWI, a physiologically decomposed DWI machine-learning model to predict pCR from DWI and clinical data. Our model first decomposes the raw DWI data into the vario…
We develop and evaluate a neural network-based method for Gibbs artifact and noise removal. A convolutional neural network (CNN) was designed for artifact removal in diffusion-weighted imaging data. Two implementations were considered: one for magnitude images and one for complex images. Both models were based on the same encoder-decoder structure and were trained by simulating MRI acquisitions on synthetic non-MRI images. Both machine learning methods were able to mitigate artifacts in diffusion-weighted images and diffusion parameter maps. The CNN for complex images was also able to reduce a…
Fast Controllable Diffusion Models for Undersampled MRI Reconstruction
School of Electrical Engineering and Computer Science, University of Queensland（昆士兰大学电气工程与计算机科学学院）；School of Mathematics and Physics, University of Queensland（昆士兰大学数学与物理学院）
We propose a model-based deep learning architecture for the reconstruction of highly accelerated diffusion magnetic resonance imaging (MRI) that enables high resolution imaging. The proposed reconstruction jointly recovers all the diffusion weighted images in a single step from a joint k-q under-sampled acquisition in a parallel MRI setting. We propose the novel use of a pre-trained denoiser as a regularizer in a model-based reconstruction for the recovery of highly under-sampled data. Specifically, we designed the denoiser based on a general diffusion MRI tissue microstructure model for multi…
