脑动脉管腔表面的表面测量
Surface Metrology of Cerebral Arteries Luminal Surface
摘要：
颈动脉和脑血管内的动脉粥样硬化病变可能影响血液动力学并表现为血管病理，包括阿尔茨海默病和缺血性中风。血流动力学受血管管腔直径变化和湍流引起的壁面切应力的影响，这与管腔的表面形貌直接相关。在这项研究中，我们进行了定量评估的颈动脉和脑动脉的血管大小和位置之间的关系的表面计量。我们推测颅内血管将跟随颅外血管的变化，大直径血管的表面粗糙度增加。从10名人体全身供体的18个不同部位采集颈内动脉、颈总动脉和Willis环多个分支的样本。使用Senior S Neox 3D光学轮廓仪分析动脉表面计量，使用SensoMap软件分析ISO 25718-2区域粗糙度参数、纹理方向、图案分析和尺度敏感分形分析。个体之间的差异最显著，尽管表面粗糙度在较大的血管中也更大。相比之下，侧面（左与右）几乎是无关紧要的。随着这一领域的深入研究，颅内动脉粥样硬化的病理生理学和动脉粥样硬化在神经退行性疾病中的作用。
英文摘要：
Atherosclerotic lesions within carotid and cerebral vessels are likely to influence hemodynamics and manifest into vascular pathologies, including Alzheimers Disease and ischemic stroke. Hemodynamics are influenced by changes in luminal diameter of vessels and wall shear stress derived from turbulence, which directly relates to the surface topography of the lumen. In this study, we performed a quantitative assessment of surface metrology of carotid and cerebral arteries in relation to vessel size and location among individuals. We speculate intracranial vessels will follow suit of extracranial vessels, with increased surface roughness in larger-diameter vessels. Samples of the internal carotid, common carotid, and multiple branches of the Circle of Willis were collected at 18 different sites from 10 human whole body donors. The arterial surface metrology was analyzed using a Sensofar S Neox 3D optical profiler, from which ISO 25718-2 areal roughness parameters, texture direction, motifs analysis, and scale-sensitive fractal analyses were analyzed using SensoMap software. The most significant differences between individuals, though surface roughness appears also greater in the larger vessels. In comparison, the side (left vs. right) is almost immaterial. With further research in this field, the pathophysiology of intracranial atherosclerosis a the role of atherosclerosis in neurodegenerative disorders.
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