去分支胸主动脉腔内修复术引起的椎动脉流量相位变化：流路与局部血管刚度对椎动脉搏动的影响
Phase changes of the flow rate in the vertebral artery caused by debranching thoracic endovascular aortic repair: effects of flow path and local vessel stiffness on vertebral arterial pulsation
AI总结：
本研究通过一维数值模型发现，dTEVAR术后左椎动脉流量相位延迟主要由旁路手术改变流路引起，而非支架植入改变血管刚度，为术后血流动力学及治疗决策提供了新见解。
摘要：
尽管对脑动脉血流已有大量研究，但目前仍缺乏对接受去分支胸主动脉腔内修复术（dTEVAR，一种治疗主动脉弓动脉瘤的有前景的手术选择）患者血流动力学的全面描述。实验观察到，与术前相比，dTEVAR术后患者左椎动脉（LVA）的流量出现相位延迟，而右椎动脉（RVA）的相位在术前和术后几乎保持不变。由于该手术干预包括支架植入和额外解剖旁路，预计dTEVAR引起的颅内血流动力学变化与脑动脉中的流体流动和脉搏波耦合。为阐明这一问题，使用一维模型（1D）数值研究了椎动脉流量对相位差的相对贡献（即局部血管刚度和流路变化）。数值结果表明，相对于术前患者，接受dTEVAR的术后患者LVA的流量出现相位延迟，但RVA没有。结果进一步显示，与术前相比，术后影响LVA流量相位延迟的主要因素是旁路（即流路的改变），而非支架植入（即局部血管刚度的变化）。数值结果为接受dTEVAR的术后患者的血流动力学提供了深入见解，以及关于治疗决策的知识。
英文摘要：
Despite numerous studies on cerebral arterial blood flow, there has not yet been a comprehensive description of hemodynamics in patients undergoing debranching thoracic endovascular aortic repair (dTEVAR), a promising surgical option for aortic arch aneurysms. A phase delay of the flow rate in the left vertebral artery (LVA) in patients after dTEVAR compared to those before was experimentally observed, while the phase in the right vertebral artery (RVA) remained almost the same before and after surgery. Since this surgical intervention included stent graft implantation and extra-anatomical bypass, it was expected that the intracranial hemodynamic changes due to dTEVAR were coupled with fluid flow and pulse waves in cerebral arteries. To clarify this issue, A one-dimensional model (1D) was used to numerically investigate the relative contribution (i.e., local vessel stiffness and flow path changes) of the VA flow rate to the phase difference. The numerical results demonstrated a phase delay of flow rate in the LVA but not the RVA in postoperative patients undergoing dTEVAR relative to preoperative patients. The results further showed that the primary factor affecting the phase delay of the flow rate in the LVA after surgery compared to that before was the bypass, i.e., alteration of flow path, rather than stent grafting, i.e., the change in local vessel stiffness. The numerical results provide insights into hemodynamics in postoperative patients undergoing dTEVAR, as well as knowledge about therapeutic decisions.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
