In this paper, we consider the problem of disease diagnosis. Unlike the conventional learning paradigm that treats labels independently, we propose a knowledge-enhanced framework, that enables training visual representation with the guidance of medical domain knowledge. In particular, we make the following contributions: First, to explicitly incorporate experts' knowledge, we propose to learn a neural representation for the medical knowledge graph via contrastive learning, implicitly establishing relations between different medical concepts. Second, while training the visual encoder, we keep the parameters of the knowledge encoder frozen and propose to learn a set of prompt vectors for efficient adaptation. Third, we adopt a Transformer-based disease-query module for cross-model fusion, which naturally enables explainable diagnosis results via cross attention. To validate the effectiveness of our proposed framework, we conduct thorough experiments on three x-ray imaging datasets across different anatomy structures, showing our model is able to exploit the implicit relations between diseases/findings, thus is beneficial to the commonly encountered problem in the medical domain, namely, long-tailed and zero-shot recognition, which conventional methods either struggle or completely fail to realize.
School of Biomedical Informatics, The University of Texas Health Science Center at Houston（德克萨斯大学休斯顿健康科学中心生物医学信息学院）；Department of Periodontics and Dental Hygiene, The University of Texas Health Science Center at Houston（德克萨斯大学休斯顿健康科学中心牙周病与口腔卫生学系）；Department of Applied Data Science, San Jose State University（圣何塞州立大学应用数据科学系）
Periodontitis is a biofilm-related chronic inflammatory disease characterized by gingivitis and bone loss in the teeth area. Approximately 61 million adults over 30 suffer from periodontitis (42.2%), with 7.8% having severe periodontitis in the United States. The measurement of radiographic bone loss (RBL) is necessary to make a correct periodontal diagnosis, especially if the comprehensive and longitudinal periodontal mapping is unavailable. However, doctors can interpret X-rays differently depending on their experience and knowledge. Computerized diagnosis support for doctors sheds light on …
AI-assisted radiographic analysis in detecting alveolar bone-loss severity and patterns
Faculty of Engineering, University of Peradeniya（工程学院，珀德尼亚大学）；Faculty of Dental Sciences, University of Peradeniya（牙科学院，珀德尼亚大学）；Simula Metropolitan Center for Digital Engineering（模拟 Metropolitan 数字工程中心）
The University of Texas Health Science Center at Houston（德克萨斯大学休斯顿健康科学中心）；The Forsyth Institute（福赛斯研究所）；Harvard University（哈佛大学）；San Jose State University（圣何塞州立大学）
Abstract: Aim: The goal was to use a Deep Convolutional Neural Network to measure the radiographic alveolar bone level to aid periodontal diagnosis. Material and methods: A Deep Learning (DL) model was developed by integrating three segmentation networks (bone area, tooth, cementoenamel junction) and image analysis to measure the radiographic bone level and assign radiographic bone loss (RBL) stages. The percentage of RBL was calculated to determine the stage of RBL for each tooth. A provisional periodontal diagnosis was assigned using the 2018 periodontitis classification. RBL percentage, sta…
Australian Institute for Machine Learning（澳大利亚机器学习研究所）；University of Adelaide（阿德莱德大学）；Peter Faber Business School, Australian Catholic University（澳大利亚天主教大学彼得·法伯商学院）；Australian Catholic University（澳大利亚天主教大学）；Amsterdam UMC（阿姆斯特丹大学医学中心）；Flinders Medical Centre（弗林德斯医学中心）；Flinders University（弗林德斯大学）；Groningen University Medical Centre（格罗宁根大学医学中心）
Convolutional neural networks (CNNs) have gained significant popularity in orthopedic imaging in recent years due to their ability to solve fracture classification problems. A common criticism of CNNs is their opaque learning and reasoning process, making it difficult to trust machine diagnosis and the subsequent adoption of such algorithms in clinical setting. This is especially true when the CNN is trained with limited amount of medical data, which is a common issue as curating sufficiently large amount of annotated medical imaging data is a long and costly process. While interest has been d…
HIST-AID: Leveraging Historical Patient Reports for Enhanced Multi-Modal Automatic Diagnosis
Courant Institute of Mathematical Sciences, New York University（纽约大学柯朗数学科学研究所）；New York University Grossman School of Medicine（纽约大学格罗斯曼医学院）；Center of Data Science, New York University（纽约大学数据科学中心）；Prescient Design, Genentech（基因泰克公司Prescient Design部门）；CIFAR LMB（加拿大高级研究院学习算法与机器智能实验室）
Center for Biomedical Image Computing and Analytics（生物医学图像计算与分析中心）；University of Pennsylvania（宾夕法尼亚大学）；Comsats University Islamabad（COMSATS伊斯兰堡大学）；Wake Forest School of Medicine（维克森林医学院）；Bowman Gray Center for Medical Education（鲍曼·格雷医学教育中心）
Both radiographic (Rad) imaging, such as multi-parametric magnetic resonance imaging, and digital pathology (Path) images captured from tissue samples are currently acquired as standard clinical practice for glioblastoma tumors. Both these data streams have been separately used for diagnosis and treatment planning, despite the fact that they provide complementary information. In this research work, we aimed to assess the potential of both Rad and Path images in combination and comparison. An extensive set of engineered features was extracted from delineated tumor regions in Rad images, compris…
Empowering Medical Imaging with Artificial Intelligence: A Review of Machine Learning Approaches for the Detection, and Segmentation of COVID-19 Using Radiographic and Tomographic Images
Clinically, the accurate annotation of lesions/tissues can significantly facilitate the disease diagnosis. For example, the segmentation of optic disc/cup (OD/OC) on fundus image would facilitate the glaucoma diagnosis, the segmentation of skin lesions on dermoscopic images is helpful to the melanoma diagnosis, etc. With the advancement of deep learning techniques, a wide range of methods proved the lesions/tissues segmentation can also facilitate the automated disease diagnosis models. However, existing methods are limited in the sense that they can only capture static regional correlations i…
Cardiac magnetic resonance (CMR) is used extensively in the diagnosis and management of cardiovascular disease. Deep learning methods have proven to deliver segmentation results comparable to human experts in CMR imaging, but there have been no convincing results for the problem of end-to-end segmentation and diagnosis from CMR. This is in part due to a lack of sufficiently large datasets required to train robust diagnosis models. In this paper, we propose a learning method to train diagnosis models, where our approach is designed to work with relatively small datasets. In particular, the opti…
A Progressive Single-Modality to Multi-Modality Classification Framework for Alzheimer's Disease Sub-type Diagnosis
School of Biomedical Engineering, ShanghaiTech University（上海科技大学生物医学工程学院）；Shanghai Artificial Intelligence Laboratory（上海人工智能实验室）；Shanghai United Imaging Intelligence Co., Ltd.（上海联影智能医疗科技有限公司）；Shanghai Clinical Research and Trial Center（上海临床研究与试验中心）
Feasibility Study of a Diffusion-Based Model for Cross-Modal Generation of Knee MRI from X-ray: Integrating Radiographic Feature Information
Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；University Sorbonne Paris Nord（巴黎北大索邦大学）；German Cancer Research Center（德国癌症研究中心）；Jiangsu Institute of Hematology（江苏血液学研究所）；The First Affiliated Hospital of Soochow University（苏州大学附属第一医院）；Henan University of Chinese Medicine（河南中医药大学）；Athinoula A. Martinos Centre for Biomedical Imaging（阿西努拉·A.马蒂诺斯生物医学成像中心）；IDP Institute（IDP研究所）；University of Orleans（奥尔良大学）
This report describes our submission to the ISIC 2017 Challenge in Skin Lesion Analysis Towards Melanoma Detection. We have participated in the Part 3: Lesion Classification with a system for automatic diagnosis of nevus, melanoma and seborrheic keratosis. Our approach aims to incorporate the expert knowledge of dermatologists into the well known framework of Convolutional Neural Networks (CNN), which have shown impressive performance in many visual recognition tasks. In particular, we have designed several networks providing lesion area identification, lesion segmentation into structural patt…
the University of Hong Kong（香港大学）；China Agricultural University（中国农业大学）；Deepwise Healthcare（深睿医疗）
During clinical practice, radiologists often use attributes, e.g. morphological and appearance characteristics of a lesion, to aid disease diagnosis. Effectively modeling attributes as well as all relationships involving attributes could boost the generalization ability and verifiability of medical image diagnosis algorithms. In this paper, we introduce a hybrid neuro-probabilistic reasoning algorithm for verifiable attribute-based medical image diagnosis. There are two parallel branches in our hybrid algorithm, a Bayesian network branch performing probabilistic causal relationship reasoning a…
Ghent University Global Campus（根特大学全球校区）；Ghent University（根特大学）
Glaucoma is a major eye disease, leading to vision loss in the absence of proper medical treatment. Current diagnosis of glaucoma is performed by ophthalmologists who are often analyzing several types of medical images generated by different types of medical equipment. Capturing and analyzing these medical images is labor-intensive and expensive. In this paper, we present a novel computational approach towards glaucoma diagnosis and localization, only making use of eye fundus images that are analyzed by state-of-the-art deep learning techniques. Specifically, our approach leverages Convolution…
School of Electronics Engineering and Computer Science Peking University（北京大学电子工程与计算机科学学院）；Institute of Sports Medicine Peking University Third Hospital（北京大学第三医院运动医学研究所）
The process of determining which disease or condition explains a person's symptoms and signs can be very complicated and may be inaccurate in some cases. The general belief is that diagnosing diseases relies on doctors' keen intuition, rich experience and professional equipment. In this work, we employ ideas from recent advances in plantar pressure research and from the powerful capacity of the convolutional neural network for learning representations. Here, we propose a model using convolutional neural network based on plantar pressure for medical diagnosis. Our model learns a network that ma…
Samsung Medical Center（三星医疗中心）；Sungkyunkwan University School of Medicine（成均馆大学医学院）；Sungkyunkwan University（成均馆大学）
The cone-beam computed tomography (CBCT) provides 3D volumetric imaging of a target with low radiation dose and cost compared with conventional computed tomography, and it is widely used in the detection of paranasal sinus disease. However, it lacks the sensitivity to detect soft tissue lesions owing to reconstruction constraints. Consequently, only physicians with expertise in CBCT reading can distinguish between inherent artifacts or noise and diseases, restricting the use of this imaging modality. The development of artificial intelligence (AI)-based computer-aided diagnosis methods for CBC…
In this work, we use a deep learning framework for simultaneous classification and regression of Parkinson disease diagnosis based on MR-Images and personal information (i.e. age, gender). We intend to facilitate and increase the confidence in Parkinson disease diagnosis through our deep learning framework.
Hebei University of Technology（河北工业大学）；University of Oxford（牛津大学）；Hospital of Joint Logistics Support Force（联勤保障部队第九八三医院）
Computer-Aided Diagnosis and Treatment of Tumors is a hot topic of deep learning in recent years, which constitutes a series of medical tasks, such as detection of tumor markers, the outline of tumor leisures, subtypes and stages of tumors, prediction of therapeutic effect, and drug development. Meanwhile, there are some deep learning models with precise positioning and excellent performance produced in mainstream task scenarios. Thus follow to introduce deep learning methods from task-orient, mainly focus on the improvements for medical tasks. Then to summarize the recent progress in four sta…
University of California, Irvine（加利福尼亚大学尔湾分校）；Anivive Lifesciences, Inc.（Anivive生命科学公司）；University of Tennessee（田纳西大学）；The University of Arizona（亚利桑那大学）
Coccidioidomycosis is the most common systemic mycosis in dogs in the southwestern United States. With warming climates, affected areas and number of cases are expected to increase in the coming years, escalating also the chances of transmission to humans. As a result, developing methods for automating the detection of the disease is important, as this will help doctors and veterinarians more easily identify and diagnose positive cases. We apply machine learning models to provide accurate and interpretable predictions of Coccidioidomycosis. We assemble a set of radiographic images and use it t…
Beijing Institute of Technology（北京理工大学）；Xuanwu Hospital, Capital Medical University（首都医科大学宣武医院）；National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College（中国医学科学院北京协和医学院肿瘤医院（国家癌症中心/国家肿瘤临床医学研究中心））
Current Computer-Aided Diagnosis (CAD) methods mainly depend on medical images. The clinical information, which usually needs to be considered in practical clinical diagnosis, has not been fully employed in CAD. In this paper, we propose a novel deep learning-based method for fusing Magnetic Resonance Imaging (MRI)/Computed Tomography (CT) images and clinical information for diagnostic tasks. Two paths of neural layers are performed to extract image features and clinical features, respectively, and at the same time clinical features are employed as the attention to guide the extraction of imag…
