Fusing Medical Image Features and Clinical Features with Deep Learning for Computer-Aided Diagnosis
Beijing Institute of Technology（北京理工大学）；Xuanwu Hospital, Capital Medical University（首都医科大学宣武医院）；National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College（中国医学科学院北京协和医学院肿瘤医院（国家癌症中心/国家肿瘤临床医学研究中心））
Songxiao Yang, Xiabi Liu, Zhongshu Zheng, Wei Wang, Xiaohong Ma
Current Computer-Aided Diagnosis (CAD) methods mainly depend on medical images. The clinical information, which usually needs to be considered in practical clinical diagnosis, has not been fully employed in CAD. In this paper, we propose a novel deep learning-based method for fusing Magnetic Resonance Imaging (MRI)/Computed Tomography (CT) images and clinical information for diagnostic tasks. Two paths of neural layers are performed to extract image features and clinical features, respectively, and at the same time clinical features are employed as the attention to guide the extraction of image features. Finally, these two modalities of features are concatenated to make decisions. We evaluate the proposed method on its applications to Alzheimer's disease diagnosis, mild cognitive impairment converter prediction and hepatic microvascular invasion diagnosis. The encouraging experimental results prove the values of the image feature extraction guided by clinical features and the concatenation of two modalities of features for classification, which improve the performance of diagnosis effectively and stably.
College of Physics and Information Engineering, Fuzhou University（福州大学物理与信息工程学院）；Thoracic Department, Fujian Medical University Union Hospital（福建医科大学附属协和医院胸外科）
Background and Objective:Computer-aided diagnosis (CAD) systems promote diagnosis effectiveness and alleviate pressure of radiologists. A CAD system for lung cancer diagnosis includes nodule candidate detection and nodule malignancy evaluation. Recently, deep learning-based pulmonary nodule detection has reached satisfactory performance ready for clinical application. However, deep learning-based nodule malignancy evaluation depends on heuristic inference from low-dose computed tomography volume to malignant probability, which lacks clinical cognition. Methods:In this paper, we propose a joint…
Shanghai Jiao Tong University（上海交通大学）；University of Georgia（佐治亚大学）；ShanghaiTech University（上海科技大学）；Shanghai United Imaging Intelligence Co., Ltd.（上海联影智能医疗科技有限公司）
When deep neural network (DNN) was first introduced to the medical image analysis community, researchers were impressed by its performance. However, it is evident now that a large number of manually labeled data is often a must to train a properly functioning DNN. This demand for supervision data and labels is a major bottleneck in current medical image analysis, since collecting a large number of annotations from experienced experts can be time-consuming and expensive. In this paper, we demonstrate that the eye movement of radiologists reading medical images can be a new form of supervision t…
A ChatGPT Aided Explainable Framework for Zero-Shot Medical Image Diagnosis
Zhejiang University-University of Illinois at Urbana-Champaign Institute（浙江大学伊利诺伊大学厄巴纳香槟校区联合学院）；Zhejiang University（浙江大学）；National University of Singapore（新加坡国立大学）；Angelalign Inc.（时代天使公司）
Large language models (LLMs) have recently demonstrated their potential in clinical applications, providing valuable medical knowledge and advice. For example, a large dialog LLM like ChatGPT has successfully passed part of the US medical licensing exam. However, LLMs currently have difficulty processing images, making it challenging to interpret information from medical images, which are rich in information that supports clinical decisions. On the other hand, computer-aided diagnosis (CAD) networks for medical images have seen significant success in the medical field by using advanced deep-le…
University of Toronto（多伦多大学）；Sunnybrook Research Institute（桑尼布鲁克研究所）
High predictive performance and ease of use and interpretability are important requirements for the applicability of a computer-aided diagnosis (CAD) to human reading studies. We propose a CAD system specifically designed to be more comprehensible to the radiologist reviewing screening breast MRI studies. Multiparametric imaging features are combined to produce a CAD system for differentiating cancerous and non-cancerous lesions. The complete system uses a rule-extraction algorithm to present lesion classification results in an easy to understand graph visualization.
Recent works on Multimodal 3D Computer-aided diagnosis have demonstrated that obtaining a competitive automatic diagnosis model when a 3D convolution neural network (CNN) brings more parameters and medical images are scarce remains nontrivial and challenging. Considering both consistencies of regions of interest in multimodal images and diagnostic accuracy, we propose a novel mutual attention-based hybrid dimensional network for MultiModal 3D medical image classification (MMNet). The hybrid dimensional network integrates 2D CNN with 3D convolution modules to generate deeper and more informativ…
Huazhong University of Science and Technology（华中科技大学）；Guizhou Normal University（贵州师范大学）；Hubei University（湖北大学）
Mapping X-ray images, radiology reports, and other medical data as binary codes in the common space, which can assist clinicians to retrieve pathology-related data from heterogeneous modalities (i.e., hashing-based cross-modal medical data retrieval), provides a new view to promot computeraided diagnosis. Nevertheless, there remains a barrier to boost medical retrieval accuracy: how to reveal the ambiguous semantics of medical data without the distraction of superfluous information. To circumvent this drawback, we propose Deep Supervised Information Bottleneck Hashing (DSIBH), which effectivel…
COVID-19 Computer-aided Diagnosis through AI-assisted CT Imaging Analysis: Deploying a Medical AI System
University of Ioannina（约阿尼纳大学）；AIandMe SMPC（AIandMe SMPC公司）；National Technical University of Athens（雅典国立技术大学）；Queen Mary University of London（伦敦大学玛丽皇后学院）
Convolutional neural networks (ConvNets) are the actual standard for image recognizement and classification. On the present work we develop a Computer Aided-Diagnosis (CAD) system using ConvNets to classify a x-rays chest images dataset in two groups: Normal and Pneumonia. The study uses ConvNets models available on the PyTorch platform: AlexNet, SqueezeNet, ResNet and Inception. We initially use three training styles: complete from scratch using random initialization, using a pre-trained ImageNet model training only the last layer adapted to our problem (transfer learning) and a pre-trained m…
Coronavirus disease (COVID-19) is a contagious infection caused by severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) and it has infected and killed millions of people across the globe. In the absence of specific drugs or vaccines for the treatment of COVID-19 and the limitation of prevailing diagnostic techniques, there is a requirement for some alternate automatic screening systems that can be used by the physicians to quickly identify and isolate the infected patients. A chest X-ray (CXR) image can be used as an alternative modality to detect and diagnose the COVID-19. In this stu…
Ghent University Global Campus（根特大学全球校区）；Ghent University（根特大学）
Glaucoma is a major eye disease, leading to vision loss in the absence of proper medical treatment. Current diagnosis of glaucoma is performed by ophthalmologists who are often analyzing several types of medical images generated by different types of medical equipment. Capturing and analyzing these medical images is labor-intensive and expensive. In this paper, we present a novel computational approach towards glaucoma diagnosis and localization, only making use of eye fundus images that are analyzed by state-of-the-art deep learning techniques. Specifically, our approach leverages Convolution…
University of Turin（都灵大学）；Azienda Ospedaliera Città della Salute e della Scienza Presidio Molinette（健康与科学城医院莫利内特分院）；AOU San Luigi Gonzaga（圣路易吉·贡扎加大学医院）
Early screening of patients is a critical issue in order to assess immediate and fast responses against the spread of COVID-19. The use of nasopharyngeal swabs has been considered the most viable approach; however, the result is not immediate or, in the case of fast exams, sufficiently accurate. Using Chest X-Ray (CXR) imaging for early screening potentially provides faster and more accurate response; however, diagnosing COVID from CXRs is hard and we should rely on deep learning support, whose decision process is, on the other hand, "black-boxed" and, for such reason, untrustworthy. We propos…
Arizona State University（亚利桑那州立大学）；University of Michigan（密歇根大学）；Mayo Clinic（梅奥诊所）
Algorithmic image-based diagnosis and prognosis of neurodegenerative diseases on longitudinal data has drawn great interest from computer vision researchers. The current state-of-the-art models for many image classification tasks are based on the Convolutional Neural Networks (CNN). However, a key challenge in applying CNN to biological problems is that the available labeled training samples are very limited. Another issue for CNN to be applied in computer aided diagnosis applications is that to achieve better diagnosis and prognosis accuracy, one usually has to deal with the longitudinal data…
Computer-aided diagnosis (CADx) systems have been shown to assist radiologists by providing classifications of all kinds of medical images like Computed tomography (CT) and Magnetic resonance (MR). Currently, convolutional neural networks play an important role in CADx. However, since CNN model should have a square-like input, it is usually difficult to directly apply the CNN algorithms on the irregular segmentation region of interests (ROIs) where the radiologists are interested in. In this paper, we propose a new approach to construct the model by extracting and converting the information of…
Federated Distillation for Medical Image Classification: Towards Trustworthy Computer-Aided Diagnosis
School of Information and Communication Engineering, Hainan University（海南大学信息与通信工程学院）；College of Mathematical Sciences, BoHai University（渤海大学数学科学学院）；Australian AI Institute, University of Technology Sydney（悉尼科技大学澳大利亚人工智能研究所）；School of Electronic Science and Technology, Hainan University（海南大学电子科学与技术学院）
Computer-Aided Osteoporosis Diagnosis Using Transfer Learning with Enhanced Features from Stacked Deep Learning Modules
Bangladesh Army University of Science and Technology（孟加拉国陆军科技大学）；Brac University（BRAC大学）；National Institute of Textile Engineering and Research (NITER)（国家纺织工程与研究所（NITER））；University of Dhaka（达卡大学）
University of Waterloo（滑铁卢大学）；University of Guelph（圭尔夫大学）；Canadian Institute of Advanced Research (CIFAR)（加拿大高等研究院）；Vector Institute（向量研究院）
Objective: Radiomics-driven Computer Aided Diagnosis (CAD) has shown considerable promise in recent years as a potential tool for improving clinical decision support in medical oncology, particularly those based around the concept of Discovery Radiomics, where radiomic sequencers are discovered through the analysis of medical imaging data. One of the main limitations with current CAD approaches is that it is very difficult to gain insight or rationale as to how decisions are made, thus limiting their utility to clinicians. Methods: In this study, we propose CLEAR-DR, a novel interpretable CAD …
Yahoo Labs（雅虎研究院）；National Institutes of Health（美国国立卫生研究院）；Georgia State University（佐治亚州立大学）；Siemens Medical Solutions Inc（西门子医疗解决方案公司）
Classification is one of the core problems in Computer-Aided Diagnosis (CAD), targeting for early cancer detection using 3D medical imaging interpretation. High detection sensitivity with desirably low false positive (FP) rate is critical for a CAD system to be accepted as a valuable or even indispensable tool in radiologists' workflow. Given various spurious imagery noises which cause observation uncertainties, this remains a very challenging task. In this paper, we propose a novel, two-tiered coarse-to-fine (CTF) classification cascade framework to tackle this problem. We first obtain classi…
Third Affiliated Hospital of Zhengzhou University, China（郑州大学第三附属医院）；Lehigh University, USA（理海大学）
Objective: Ultrahigh-resolution optical coherence microscopy (OCM) has recently demonstrated its potential for accurate diagnosis of human cervical diseases. One major challenge for clinical adoption, however, is the steep learning curve clinicians need to overcome to interpret OCM images. Developing an intelligent technique for computer-aided diagnosis (CADx) to accurately interpret OCM images will facilitate clinical adoption of the technology and improve patient care. Methods: 497 high-resolution 3-D OCM volumes (600 cross-sectional images each) were collected from 159 ex vivo specimens of …
Broad Institute of Harvard and MIT（哈佛大学与麻省理工学院博德研究所）；Dana-Farber Cancer Institute（丹娜法伯癌症研究院）；Department of Biomedical Informatics, Harvard Medical School（哈佛医学院生物医学信息学系）
Cancer diagnosis, prognosis, and therapeutic response predictions are based on morphological information from histology slides and molecular profiles from genomic data. However, most deep learning-based objective outcome prediction and grading paradigms are based on histology or genomics alone and do not make use of the complementary information in an intuitive manner. In this work, we propose Pathomic Fusion, an interpretable strategy for end-to-end multimodal fusion of histology image and genomic (mutations, CNV, RNA-Seq) features for survival outcome prediction. Our approach models pairwise…
Northeastern University（东北大学）；Cancer Hospital, China Medical University（中国医科大学肿瘤医院）；Liaoning Cancer Hospital and Institute（辽宁省肿瘤医院和研究所）；Heilongjiang University（黑龙江大学）；Stevens Institute of Technology（斯蒂文斯理工学院）；Shengjing Hospital, China Medical University（中国医科大学盛京医院）；University of Luebeck（吕贝克大学）
Background and Objective: Gastric cancer has turned out to be the fifth most common cancer globally, and early detection of gastric cancer is essential to save lives. Histopathological examination of gastric cancer is the gold standard for the diagnosis of gastric cancer. However, computer-aided diagnostic techniques are challenging to evaluate due to the scarcity of publicly available gastric histopathology image datasets. Methods: In this paper, a noble publicly available Gastric Histopathology Sub-size Image Database (GasHisSDB) is published to identify classifiers' performance. Specificall…
Magnetic Resonance Imaging (MRI) is widely used for screening and staging prostate cancer. However, many prostate cancers have subtle features which are not easily identifiable on MRI, resulting in missed diagnoses and alarming variability in radiologist interpretation. Machine learning models have been developed in an effort to improve cancer identification, but current models localize cancer using MRI-derived features, while failing to consider the disease pathology characteristics observed on resected tissue. In this paper, we propose CorrSigNet, an automated two-step model that localizes p…
Technical University of Munich（慕尼黑工业大学）；Klinikum Rechts der Isar, Technical University of Munich（慕尼黑工业大学 rechts der Isar 医院）；Fudan University（复旦大学）
The lethal nature of pancreatic ductal adenocarcinoma (PDAC) calls for early differential diagnosis of pancreatic cysts, which are identified in up to 16% of normal subjects, and some of which may develop into PDAC. Previous computer-aided developments have achieved certain accuracy for classification on segmented cystic lesions in CT. However, pancreatic cysts have a large variation in size and shape, and the precise segmentation of them remains rather challenging, which restricts the computer-aided interpretation of CT images acquired for differential diagnosis. We propose a computer-aided f…
University of Central Florida（中佛罗里达大学）；National Institutes of Health（美国国立卫生研究院）
There are at least two categories of errors in radiology screening that can lead to suboptimal diagnostic decisions and interventions:(i)human fallibility and (ii)complexity of visual search. Computer aided diagnostic (CAD) tools are developed to help radiologists to compensate for some of these errors. However, despite their significant improvements over conventional screening strategies, most CAD systems do not go beyond their use as second opinion tools due to producing a high number of false positives, which human interpreters need to correct. In parallel with efforts in computerized analy…
UniCAD: Efficient and Extendable Architecture for Multi-Task Computer-Aided Diagnosis System
School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University（生物医学工程学院及先进医疗材料与设备国家重点实验室，上海科技大学）；School of Biomedical Engineering, Shanghai Jiao Tong University（生物医学工程学院，上海交通大学）；Shanghai Clinical Research and Trial Center（上海临床研究与试验中心）；Shanghai United Imaging Intelligence Co. Ltd.（上海联合影像智能科技有限公司）
Stevens Institute of Technology（史蒂文斯理工学院）；University of Luebeck（吕贝克大学）；Northeastern University（东北大学）；China Medical University（中国医科大学）
With the development of computer-aided diagnosis (CAD) and image scanning technology, Whole-slide Image (WSI) scanners are widely used in the field of pathological diagnosis. Therefore, WSI analysis has become the key to modern digital pathology. Since 2004, WSI has been used more and more in CAD. Since machine vision methods are usually based on semi-automatic or fully automatic computers, they are highly efficient and labor-saving. The combination of WSI and CAD technologies for segmentation, classification, and detection helps histopathologists obtain more stable and quantitative analysis r…
Manchester Metropolitan University（曼彻斯特城市大学）；Nanjing University of Aeronautics and Astronautics（南京航空航天大学）
Computer-aided early diagnosis of Alzheimer's disease (AD) and its prodromal form mild cognitive impairment (MCI) based on structure Magnetic Resonance Imaging (sMRI) has provided a cost-effective and objective way for early prevention and treatment of disease progression, leading to improved patient care. In this work, we have proposed a novel computer-aided approach for early diagnosis of AD by introducing an explainable 3D Residual Attention Deep Neural Network (3D ResAttNet) for end-to-end learning from sMRI scans. Different from the existing approaches, the novelty of our approach is thre…
Institut de Robòtica i Informàtica Industrial, UPC-CSIC（加泰罗尼亚理工大学-西班牙国家研究委员会机器人与工业信息技术研究所）；Institut Pediàtric de Malalties Rares, Hospital de Sant Joan de Déu（罕见病儿科研究所，圣若安·德乌医院）；Hospital de Sant Joan de Déu（圣若安·德乌医院）
The development of machine learning systems for the diagnosis of rare diseases is challenging mainly due the lack of data to study them. Despite this challenge, this paper proposes a system for the Computer Aided Diagnosis (CAD) of low-prevalence, congenital muscular dystrophies from confocal microscopy images. The proposed CAD system relies on a Convolutional Neural Network (CNN) which performs an independent classification for non-overlapping patches tiling the input image, and generates an overall decision summarizing the individual decisions for the patches on the query image. This decisio…
Massachusetts General Hospital（麻省总医院）；Zhejiang University（浙江大学）；University of Michigan（密歇根大学）；Beijing Institute of Technology（北京理工大学）
Tissue characterization has long been an important component of Computer Aided Diagnosis (CAD) systems for automatic lesion detection and further clinical planning. Motivated by the superior performance of deep learning methods on various computer vision problems, there has been increasing work applying deep learning to medical image analysis. However, the development of a robust and reliable deep learning model for computer-aided diagnosis is still highly challenging due to the combination of the high heterogeneity in the medical images and the relative lack of training samples. Specifically,…
A Computer-aided Framework for Detecting Osteosarcoma in Computed Tomography Scans
Universidad Carlos III de Madrid, Departamento de Informática, ARCOS, Avenida de la Universidad, 30 (edificio Sabatini), 28911 Leganés (Madrid), España（卡洛斯三世大学马德里分校，信息学院，ARCOS，大学大道30号（萨巴蒂尼大楼），28911 Leganés（马德里），西班牙）；Cinvestav Tamaulipas, Cd. Victoria, Tamaulipas, México（塔毛利帕斯大学，维克多城，塔毛利帕斯，墨西哥）
Northwestern Polytechnical University（西北工业大学）；Tianjin Medical University（天津医科大学）
Goal: Squamous cell carcinoma of cervix is one of the most prevalent cancer worldwide in females. Traditionally, the most indispensable diagnosis of cervix squamous carcinoma is histopathological assessment which is achieved under microscope by pathologist. However, human evaluation of pathology slide is highly depending on the experience of pathologist, thus big inter- and intra-observer variability exists. Digital pathology, in combination with deep learning provides an opportunity to improve the objectivity and efficiency of histopathologic slide analysis. Methods: In this study, we obtaine…
Research Computing Center at the University of Chicago（芝加哥大学研究计算中心）
Prostate cancer is one of the most common causes of cancer deaths in men. There is a growing demand for noninvasively and accurately diagnostic methods that facilitate the current standard prostate cancer risk assessment in clinical practice. Still, developing computer-aided classification tools in prostate cancer diagnostics from multiparametric magnetic resonance images continues to be a challenge. In this work, we propose a novel deep learning approach for automatic classification of prostate lesions in the corresponding magnetic resonance images by constructing a two-stage multimodal multi…
We introduce a new computer aided detection and diagnosis system for lung cancer screening with low-dose CT scans that produces meaningful probability assessments. Our system is based entirely on 3D convolutional neural networks and achieves state-of-the-art performance for both lung nodule detection and malignancy classification tasks on the publicly available LUNA16 and Kaggle Data Science Bowl challenges. While nodule detection systems are typically designed and optimized on their own, we find that it is important to consider the coupling between detection and diagnosis components. Exploiti…
While microscopic analysis of histopathological slides is generally considered as the gold standard method for performing cancer diagnosis and grading, the current method for analysis is extremely time consuming and labour intensive as it requires pathologists to visually inspect tissue samples in a detailed fashion for the presence of cancer. As such, there has been significant recent interest in computer aided diagnosis systems for analysing histopathological slides for cancer grading to aid pathologists to perform cancer diagnosis and grading in a more efficient, accurate, and consistent ma…
FusionFM: Fusing Eye-specific Foundational Models for Optimized Ophthalmic Diagnosis
Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore（新加坡国立大学 Yong Loo Lin 医学院眼科系）；Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore（新加坡国立大学 Yong Loo Lin 医学院创新与精准眼科健康中心）；Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore（新加坡眼科研究院）；Ophthalmology and Visual Science Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore（杜克-国立新加坡大学医学学校眼科与视觉科学学术临床项目）；Centre for Medical Image Computing, University College London, London, United Kingdom（伦敦大学学院医学图像计算中心）；Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, China（汕尾国际眼科中心，汕尾大学及香港中文大学）；Department of Ophthalmology, Stadtspital Zürich, Zurich, Switzerland（苏黎世州立医院眼科部）；Spross Research Institute, Zurich, Switzerland（苏黎世 Spross 研究院）；Institute of High Performance Computing, A*STAR, Singapore（新加坡 A*STAR 高性能计算研究院）；NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom（英国国家健康服务基金会 Moorfields 眼科医院生物医学研究中心）；Institute of Ophthalmology, University College London, London, United Kingdom（伦敦大学学院眼科研究院）
School of Computing and Information Technology, University of Wollongong（卧龙岗大学计算与信息技术学院）
The Coronavirus Disease 2019 (COVID-19) is affecting increasingly large number of people worldwide, posing significant stress to the health care systems. Early and accurate diagnosis of COVID-19 is critical in screening of infected patients and breaking the person-to-person transmission. Chest X-ray (CXR) based computer-aided diagnosis of COVID-19 using deep learning becomes a promising solution to this end. However, the diverse and various radiographic features of COVID-19 make it challenging, especially when considering each CXR scan typically only generates one single image. Data scarcity i…
AWGUNET: Attention-Aided Wavelet Guided U-Net for Nuclei Segmentation in Histopathology Images
Jadavpur University（jadavpur大学）；Artificial Intelligence Research Institute, China University of Mining and Technology（中国矿业大学人工智能研究院）；Saint Petersburg Electrotechnical University "LETI"（圣彼得堡国立电工技术大学"LETI"）
Royal College of Art（皇家艺术学院）；University of Warwick（华威大学）
Computer-assisted multimodal training is an effective way of learning complex motor skills in various applications. In particular disciplines (eg. healthcare) incompetency in performing dexterous hands-on examinations (clinical palpation) may result in misdiagnosis of symptoms, serious injuries or even death. Furthermore, a high quality clinical examination can help to exclude significant pathology, and reduce time and cost of diagnosis by eliminating the need for unnecessary medical imaging. Medical palpation is used regularly as an effective preliminary diagnosis method all around the world …
We introduce a new dataset called Synthetic COVID-19 Chest X-ray Dataset for training machine learning models. The dataset consists of 21,295 synthetic COVID-19 chest X-ray images to be used for computer-aided diagnosis. These images, generated via an unsupervised domain adaptation approach, are of high quality. We find that the synthetic images not only improve performance of various deep learning architectures when used as additional training data under heavy imbalance conditions, but also detect the target class with high confidence. We also find that comparable performance can also be achi…
Low grade endometrial stromal sarcoma (LGESS) is rare form of cancer, accounting for about 0.2% of all uterine cancer cases. Approximately 75% of LGESS patients are initially misdiagnosed with leiomyoma, which is a type of benign tumor, also known as fibroids. In this research, uterine tissue biopsy images of potential LGESS patients are preprocessed using segmentation and staining normalization algorithms. A variety of classic machine learning and leading deep learning models are then applied to classify tissue images as either benign or cancerous. For the classic techniques considered, the h…
Hebei University of Technology（河北工业大学）；University of Oxford（牛津大学）；Hospital of Joint Logistics Support Force（联勤保障部队第九八三医院）
Computer-Aided Diagnosis and Treatment of Tumors is a hot topic of deep learning in recent years, which constitutes a series of medical tasks, such as detection of tumor markers, the outline of tumor leisures, subtypes and stages of tumors, prediction of therapeutic effect, and drug development. Meanwhile, there are some deep learning models with precise positioning and excellent performance produced in mainstream task scenarios. Thus follow to introduce deep learning methods from task-orient, mainly focus on the improvements for medical tasks. Then to summarize the recent progress in four sta…
The inability to interpret the model prediction in semantically and visually meaningful ways is a well-known shortcoming of most existing computer-aided diagnosis methods. In this paper, we propose MDNet to establish a direct multimodal mapping between medical images and diagnostic reports that can read images, generate diagnostic reports, retrieve images by symptom descriptions, and visualize attention, to provide justifications of the network diagnosis process. MDNet includes an image model and a language model. The image model is proposed to enhance multi-scale feature ensembles and utiliza…
University of Oulu（奥卢大学）；Tampere University of Technology（坦佩雷理工大学）；Oulu University Hospital（奥卢大学医院）
Knee osteoarthritis (OA) is the most common musculoskeletal disorder. OA diagnosis is currently conducted by assessing symptoms and evaluating plain radiographs, but this process suffers from subjectivity. In this study, we present a new transparent computer-aided diagnosis method based on the Deep Siamese Convolutional Neural Network to automatically score knee OA severity according to the Kellgren-Lawrence grading scale. We trained our method using the data solely from the Multicenter Osteoarthritis Study and validated it on randomly selected 3,000 subjects (5,960 knees) from Osteoarthritis …
Edith Cowan University（伊迪丝·考恩大学）；University of Western Australia（西澳大利亚大学）
Deep learning is gaining instant popularity in computer aided diagnosis of COVID-19. Due to the high sensitivity of Computed Tomography (CT) to this disease, CT-based COVID-19 detection with visual models is currently at the forefront of medical imaging research. Outcomes published in this direction are frequently claiming highly accurate detection under deep transfer learning. This is leading medical technologists to believe that deep transfer learning is the mainstream solution for the problem. However, our critical analysis of the literature reveals an alarming performance disparity between…
Northeastern University（东北大学）；China Medical University（中国医科大学）；University of Luebeck（吕贝克大学）
The gold standard for gastric cancer detection is gastric histopathological image analysis, but there are certain drawbacks in the existing histopathological detection and diagnosis. In this paper, based on the study of computer aided diagnosis system, graph based features are applied to gastric cancer histopathology microscopic image analysis, and a classifier is used to classify gastric cancer cells from benign cells. Firstly, image segmentation is performed, and after finding the region, cell nuclei are extracted using the k-means method, the minimum spanning tree (MST) is drawn, and graph …
University of Idaho（爱达荷大学）；Harbin Institute of Technology（哈尔滨工业大学）；Medical College at Qingdao University（青岛大学医学院）
Deep learning-based computer-aided diagnosis has achieved unprecedented performance in breast cancer detection. However, most approaches are computationally intensive, which impedes their broader dissemination in real-world applications. In this work, we propose an efficient and light-weighted multitask learning architecture to classify and segment breast tumors simultaneously. We incorporate a segmentation task into a tumor classification network, which makes the backbone network learn representations focused on tumor regions. Moreover, we propose a new numerically stable loss function that e…
Hong Kong Baptist University（香港浸会大学）；Harbin Institute of Technology（哈尔滨工业大学）；The University of Hong Kong - Shenzhen Hospital（香港大学深圳医院）；Shenzhen Yiyuan Intelligent Technology Co., Ltd.（深圳怡园智能科技有限公司）
Skin disease is one of the most common types of human diseases, which may happen to everyone regardless of age, gender or race. Due to the high visual diversity, human diagnosis highly relies on personal experience; and there is a serious shortage of experienced dermatologists in many countries. To alleviate this problem, computer-aided diagnosis with state-of-the-art (SOTA) machine learning techniques would be a promising solution. In this paper, we aim at understanding the performance of convolutional neural network (CNN) based approaches. We first build two versions of skin disease datasets…
The Third Affiliated Hospital of Tsinghua University（清华大学附属北京清华长庚医院）；Zhengzhou University（郑州大学）
As a disease with malignant potential, hydatidiform mole (HM) is one of the most common gestational trophoblastic diseases. For pathologists, the HM section of hydrops lesions is an important basis for diagnosis. In pathology departments, the diverse microscopic manifestations of HM lesions and the limited view under the microscope mean that physicians with extensive diagnostic experience are required to prevent missed diagnosis and misdiagnosis. Feature extraction can significantly improve the accuracy and speed of the diagnostic process. As a remarkable diagnosis assisting technology, comput…
NMAM Institute of Technology（NMAM理工学院）；Visvesvaraya Technological University（韦斯韦斯瓦拉亚理工大学）；Sahyadri College of Engineering and Management（萨亚德里工程与管理学院）；JSS Academy of Technical Education（JSS技术教育学院）
Lung cancer begins in the lungs and leading to the reason of cancer demise amid population in the creation. According to the American Cancer Society, which estimates about 27% of the deaths because of cancer. In the early phase of its evolution, lung cancer does not cause any symptoms usually. Many of the patients have been diagnosed in a developed phase where symptoms become more prominent, that results in poor curative treatment and high mortality rate. Computer Aided Detection systems are used to achieve greater accuracies for the lung cancer diagnosis. In this research exertion, we propose…
We evaluate two different methods for the integration of prediction uncertainty into diagnostic image classifiers to increase patient safety in deep learning. In the first method, Monte Carlo sampling is applied with dropout at test time to get a posterior distribution of the class labels (Bayesian ResNet). The second method extends ResNet to a probabilistic approach by predicting the parameters of the posterior distribution and sampling the final result from it (Variational ResNet).The variance of the posterior is used as metric for uncertainty.Both methods are trained on a data set of optica…
Vrije Universiteit（阿姆斯特丹自由大学）；Amsterdam UMC（阿姆斯特丹大学医学中心）；Amsterdam Neuroscience（阿姆斯特丹神经科学研究所）；Erasmus MC（伊拉斯姆斯医学中心）；University College London（伦敦大学学院）；TU Delft（代尔夫特理工大学）
Computer-aided methods have shown added value for diagnosing and predicting brain disorders and can thus support decision making in clinical care and treatment planning. This chapter will provide insight into the type of methods, their working, their input data - such as cognitive tests, imaging and genetic data - and the types of output they provide. We will focus on specific use cases for diagnosis, i.e. estimating the current 'condition' of the patient, such as early detection and diagnosis of dementia, differential diagnosis of brain tumours, and decision making in stroke. Regarding predic…
Shenzhen University（深圳大学）；Guangdong Province Traditional Chinese Medical Hospital（广东省中医院）
Automated breast ultrasound (ABUS) is a new and promising imaging modality for breast cancer detection and diagnosis, which could provide intuitive 3D information and coronal plane information with great diagnostic value. However, manually screening and diagnosing tumors from ABUS images is very time-consuming and overlooks of abnormalities may happen. In this study, we propose a novel two-stage 3D detection network for locating suspected lesion areas and further classifying lesions as benign or malignant tumors. Specifically, we propose a 3D detection network rather than frequently-used segme…
The past years have seen a considerable increase in cancer cases. However, a cancer diagnosis is often complex and depends on the types of images provided for analysis. It requires highly skilled practitioners but is often time-consuming and error-prone. If Machine Learning and deep learning algorithms have been widely used, a comprehensive review of the techniques used from the pre-processing steps to the final prediction is lacking. With this review, we aim to provide a comprehensive overview of the current steps required in building efficient and accurate machine learning algorithm for canc…
College of Information Science and Technology, Northwest University（西北大学信息科学与技术学院）；University of Texas Southwestern Medical Center（德克萨斯大学西南医学中心）
Breast ultrasound (US) is an effective imaging modality for breast cancer detec-tion and diagnosis. The structural characteristics of breast lesion play an im-portant role in Computer-Aided Diagnosis (CAD). In this paper, a novel struc-ture-aware triplet path networks (SATPN) was designed to integrate classifica-tion and two image reconstruction tasks to achieve accurate diagnosis on US im-ages with small training dataset. Specifically, we enhance clinically-approved breast lesion structure characteristics though converting original breast US imag-es to BIRADS-oriented feature maps (BFMs) with…
Universidad Técnica Particular de Loja（洛哈技术大学）；Instituto de Instrumentacion para la Imagen Molecular I3M, Universitat Politécnica de Valencia（瓦伦西亚理工大学分子图像仪器研究所I3M）；University of Waterloo（滑铁卢大学）
This paper provides a critical review of the literature on deep learning applications in breast tumor diagnosis using ultrasound and mammography images. It also summarizes recent advances in computer-aided diagnosis (CAD) systems, which make use of new deep learning methods to automatically recognize images and improve the accuracy of diagnosis made by radiologists. This review is based upon published literature in the past decade (January 2010 January 2020). The main findings in the classification process reveal that new DL-CAD methods are useful and effective screening tools for breast cance…
