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arXiv 2301.03057stat.ME
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在加速失败时间模型下刻画分位数变化的协变量效应

Characterizing quantile-varying covariate effects under the accelerated failure time model

Harvard T.H. Chan School of Public Health(哈佛大学陈曾熙公共卫生学院)

Harrison T. Reeder, Kyu Ha Lee, Sebastien Haneuse

AI总结:

本文提出在加速失败时间模型下刻画分位数变化的协变量效应的框架,通过灵活回归结构和贝叶斯方法,实现对生存分位数效应的解释和估计。

摘要:

生存分析中一个重要任务是确定感兴趣的协变量与时间到事件结果之间关系的结构。例如,加速失败时间(AFT)模型将每个协变量效应视为在所有生存分位数上对结果分布的恒定乘法位移。尽管简洁,这种结构无法检测或捕捉不同分布分位数的效应,这一限制类似于在Cox模型中仅允许比例危险。为解决此问题,我们提出了一种在AFT模型下适用于分位数变化的乘法效应的一般框架。具体来说,我们在AFT模型中嵌入了灵活的回归结构,并推导出一个新颖的公式,用于在分位数尺度上解释效应。我们提出了一种基于g公式回归标准化方案,以实现对感兴趣暴露的协变量条件效应和边际效应的估计。我们实现了一种用户友好的贝叶斯方法进行估计和不确定性量化,同时考虑左截断和复杂的删失。我们强调通过数值和图形工具直观解释此模型,并通过模拟和应用到阿尔茨海默病和痴呆症研究中来展示其性能。

英文摘要:

An important task in survival analysis is choosing a structure for the relationship between covariates of interest and the time-to-event outcome. For example, the accelerated failure time (AFT) model structures each covariate effect as a constant multiplicative shift in the outcome distribution across all survival quantiles. Though parsimonious, this structure cannot detect or capture effects that differ across quantiles of the distribution, a limitation that is analogous to only permitting proportional hazards in the Cox model. To address this, we propose a general framework for quantile-varying multiplicative effects under the AFT model. Specifically, we embed flexible regression structures within the AFT model, and derive a novel formula for interpretable effects on the quantile scale. A regression standardization scheme based on the g-formula is proposed to enable estimation of both covariate-conditional and marginal effects for an exposure of interest. We implement a user-friendly Bayesian approach for estimation and quantification of uncertainty, while accounting for left truncation and complex censoring. We emphasize the intuitive interpretation of this model through numerical and graphical tools, and illustrate its performance through simulation and application to a study of Alzheimer's disease and dementia.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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