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arXiv 1609.04778stat.ME
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协变量条件下高维分位数关联网络的错误发现率控制

False Discovery Rate Control for High-Dimensional Networks of Quantile Associations Conditioning on Covariates

Jichun Xie, Ruosha Li

摘要:

受基因共表达模式分析的启发,我们提出了一种新型的基于样本分位数的偶然(squac)统计量来推断基于协变量的分位数关联。它具有增强的灵活性,可以处理任意分布的变量和以协变量为条件的复杂关联模式。我们首先推导出它的渐近零分布,然后开发了一个基于squac的多重检验程序,同时检验所有$p(p-1)/2$对的协变量条件下的一对变量之间的独立性。这里,$p$是结局的长度,可能超过样本量。该测试过程不需要复位或扰动,因此计算效率高。通过理论和数值实验证明了该测试方法渐近控制错误发现率(\FDR)。当存在复杂的关联情况时,该方法优于所有的替代方法。将该方法应用于一个胃癌数据,成功地推断出了早期和晚期患者的基因共表达网络。它确定了与癌症存活率相关的网络中的更多变化。我们将我们的方法推广到结果的长度和协变量的长度都超过样本量的情况,并证明了渐近理论仍然成立。

英文摘要:

Motivated by the gene co-expression pattern analysis, we propose a novel sample quantile-based contingency (squac) statistic to infer quantile associations conditioning on covariates. It features enhanced flexibility in handling variables with both arbitrary distributions and complex association patterns conditioning on covariates. We first derive its asymptotic null distribution, and then develop a multiple testing procedure based on squac to simultaneously test the independence between one pair of variables conditioning on covariates for all $p(p-1)/2$ pairs. Here, $p$ is the length of the outcomes and could exceed the sample size. The testing procedure does not require resampling or perturbation, and thus is computationally efficient. We prove by theory and numerical experiments that this testing method asymptotically controls the false discovery rate (\FDR). It outperforms all alternative methods when the complex association panterns exist. Applied to a gastric cancer data, this testing method successfully inferred the gene co-expression networks of early and late stage patients. It identified more changes in the networks which are associated with cancer survivals. We extend our method to the case that both the length of the outcomes and the length of covariates exceed the sample size, and show that the asymptotic theory still holds.

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