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arXiv 2208.03396stat.MEq-bio.QMstat.ML
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多源多路数据的贝叶斯预测建模

Bayesian predictive modeling of multi-source multi-way data

Jonathan Kim, Brian J. Sandri, Raghavendra B. Rao, Eric F. Lock

摘要:

我们开发了一种贝叶斯方法来预测从多个来源收集的数据的连续或二进制结果,具有多路(即。多维张量)结构。作为一个激励性的例子,我们考虑来自多个组学来源的分子数据,每个在多个发育时间点测量,作为恒河猴模型中早期生活铁缺乏症(ID)的预测因子。我们使用一个线性模型与低秩结构的系数捕捉多路依赖性和模型的方差系数分别跨每个源,以推断其相对的贡献。共轭先验便于后验推理的有效吉布斯抽样算法,假设具有正态误差的连续结果或具有概率位链接的二进制结果。仿真结果表明,我们的模型在误分类率和估计系数与真实系数的相关性方面的表现与预期一致,在考虑不同来源的不同信号大小时,通过采用多路结构和适度增益,性能获得了很大的增益。此外,它为我们的激励应用程序提供了ID猴子的强大分类。R代码形式的软件可在https://github.com/BiostatsKim/BayesMSMW上获得。

英文摘要:

We develop a Bayesian approach to predict a continuous or binary outcome from data that are collected from multiple sources with a multi-way (i.e.. multidimensional tensor) structure. As a motivating example we consider molecular data from multiple 'omics sources, each measured over multiple developmental time points, as predictors of early-life iron deficiency (ID) in a rhesus monkey model. We use a linear model with a low-rank structure on the coefficients to capture multi-way dependence and model the variance of the coefficients separately across each source to infer their relative contributions. Conjugate priors facilitate an efficient Gibbs sampling algorithm for posterior inference, assuming a continuous outcome with normal errors or a binary outcome with a probit link. Simulations demonstrate that our model performs as expected in terms of misclassification rates and correlation of estimated coefficients with true coefficients, with large gains in performance by incorporating multi-way structure and modest gains when accounting for differing signal sizes across the different sources. Moreover, it provides robust classification of ID monkeys for our motivating application. Software in the form of R code is available at https://github.com/BiostatsKim/BayesMSMW .

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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