Medical imaging is the most important tool for detecting complications in the inner body of medicine. Nowadays, with the development of image processing technology as well as changing the size of photos to higher resolution images in the field of digital medical imaging, there is an efficient and accurate system for segmenting this. Real-world images that for a variety of reasons have poor heterogeneity, noise and contrast are essential. Digital image segmentation in medicine is used for diagnostic and therapeutic analysis, which is very helpful for physicians. In this study, we aim at liver cancer photographs, which aim to more accurately detect the lesion or tumor of the liver because accurate and timely detection of the tumor is very important in the survival and life of the patient.The aim of this paper is to simplify the obnoxious study problems related to the study of MR images. The liver is the second organ most generic involved by metastatic disease being liver cancer one of the prominent causes of death worldwide. Without healthy liver a person cannot survive. It is life threatening disease which is very challenging perceptible for both medical and engineering technologists. Medical image processing is used as a non-invasive method to detect tumours. The chances of survival having liver Tumor highly depends on early detection of Tumor and then classification as cancerous and noncancerous tumours. Image processing techniques for automatic detection of brain are includes pre-processing and enhancement, image segmentation, classification and volume calculation, Poly techniques have been developed for the detection of liver Tumor and different liver toM oR detection algorithms and methodologies utilized for Tumor diagnosis. Novel methodology for the detection and diagnosis of liver Tumor.
The Chinese University of Hong Kong（香港中文大学）；Imsight Medical Technology, Inc.（伊赛智能医疗科技有限公司）
Liver cancer is one of the leading causes of cancer death. To assist doctors in hepatocellular carcinoma diagnosis and treatment planning, an accurate and automatic liver and tumor segmentation method is highly demanded in the clinical practice. Recently, fully convolutional neural networks (FCNs), including 2D and 3D FCNs, serve as the back-bone in many volumetric image segmentation. However, 2D convolutions can not fully leverage the spatial information along the third dimension while 3D convolutions suffer from high computational cost and GPU memory consumption. To address these issues, we …
Recent breakthroughs in object detection and image classification using Convolutional Neural Networks (CNNs) are revolutionizing the state of the art in medical imaging, and microscopy in particular presents abundant opportunities for computer vision algorithms to assist medical professionals in diagnosis of diseases ranging from malaria to cancer. High resolution scans of microscopy slides called Whole Slide Images (WSIs) offer enough information for a cancer pathologist to come to a conclusion regarding cancer presence, subtype, and severity based on measurements of features within the slide…
Uncertainty-Aware Segmentation Quality Prediction via Deep Learning Bayesian Modeling: Comprehensive Evaluation and Interpretation on Skin Cancer and Liver Segmentation
BCN Medtech（BCN医学科技）；Scientific and Technical Department, Sycai Technologies S.L.（Sycai技术部门）
Semantic Segmentation-Driven Image-Level Diagnosis of Liver Cancers in Hematoxylin and Eosin Histopathology Images
Division of Computing and Data Science, Ruđer Bošković Institute（鲁德·波斯科维奇研究所计算与数据科学部）；Sitnik Ventures UG（Sitnik Ventures公司）；Department of Pathology and Cytology, Dubrava University Hospital（杜布拉瓦大学医院病理科与细胞学部）；Clinical Division for Pathology and Cytology, Clinical Hospital Center Zagreb（扎格雷布临床医院中心病理科与细胞学部）；Division of Molecular Medicine, Ruđer Bošković Institute（鲁德·波斯科维奇研究所分子医学部）
Artificial Intelligence-Enhanced Couinaud Segmentation for Precision Liver Cancer Therapy
Stanford University（斯坦福大学）；University of Southern California（南加州大学）；Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；Wake Forest University（维克森林大学）；Shandong Provincial Hospital Affiliated to Shandong First Medical University（山东第一医科大学附属山东省立医院）；Shandong First Medical University（山东第一医科大学）
AI generated annotations for Breast, Brain, Liver, Lungs and Prostate cancer collections in National Cancer Institute Imaging Data Commons
BAMF Health（BAMF健康公司）；National Institute of Health（美国国立卫生研究院）；Frederick National Laboratory for Cancer Research（弗雷德里克国家癌症研究实验室）；Brigham and Women’s Hospital（布莱根妇女医院）；Harvard Medical School（哈佛医学院）
INSA Centre Val de Loire（卢瓦尔河谷国立应用科学学院）；PRISME（PRISME实验室）
This paper addresses the problem of liver cancer segmentation in Whole Slide Image (WSI). We propose a multi-scale image processing method based on automatic end-to-end deep neural network algorithm for segmentation of cancer area. A seven-levels gaussian pyramid representation of the histopathological image was built to provide the texture information in different scales. In this work, several neural architectures were compared using the original image level for the training procedure. The proposed method is based on U-Net applied to seven levels of various resolutions (pyramidal subsumpling)…
A Classification-Based Adaptive Segmentation Pipeline: Feasibility Study Using Polycystic Liver Disease and Metastases from Colorectal Cancer CT Images
Washington State University（华盛顿州立大学）；M.D. Anderson Cancer Center, University of Texas（德克萨斯大学MD安德森癌症中心）
Tumor detection in biomedical imaging is a time-consuming process for medical professionals and is not without errors. Thus in recent decades, researchers have developed algorithmic techniques for image processing using a wide variety of mathematical methods, such as statistical modeling, variational techniques, and machine learning. In this paper, we propose a semi-automatic method for liver segmentation of 2D CT scans into three labels denoting healthy, vessel, or tumor tissue based on graph cuts. First, we create a feature vector for each pixel in a novel way that consists of the 59 intensi…
National Institutes of Health Clinical Center（美国国立卫生研究院临床中心）；Ping An Insurance Company of China（中国平安保险公司）
Developing an effective liver and liver tumor segmentation model from CT scans is very important for the success of liver cancer diagnosis, surgical planning and cancer treatment. In this work, we propose a two-stage framework for 2D liver and tumor segmentation. The first stage is a coarse liver segmentation network, while the second stage is an edge enhanced network (E$^2$Net) for more accurate liver and tumor segmentation. E$^2$Net explicitly models complementary objects (liver and tumor) and their edge information within the network to preserve the organ and lesion boundaries. We introduce…
A Multimodal Deep Learning Framework for Early Diagnosis of Liver Cancer via Optimized BiLSTM-AM-VMD Architecture
Department of Encephalopathy, Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu 611730, China（成都Pidu区中医医院神经病科）；Department of Tuina, Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu 611730, China（成都Pidu区中医医院推拿科）；Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA（卡内基梅隆大学电气与计算机工程系）
Institute of Computing Technology, Chinese Academy of Sciences（中国科学院计算技术研究所）；University of Chinese Academy of Sciences（中国科学院大学）；University of California, Los Angeles（加利福尼亚大学洛杉矶分校）；Lenovo Research（联想研究院）；Lenovo Ltd.（联想集团有限公司）
Liver cancer is one of the most common cancers worldwide. Due to inconspicuous texture changes of liver tumor, contrast-enhanced computed tomography (CT) imaging is effective for the diagnosis of liver cancer. In this paper, we focus on improving automated liver tumor segmentation by integrating multi-modal CT images. To this end, we propose a novel mutual learning (ML) strategy for effective and robust multi-modal liver tumor segmentation. Different from existing multi-modal methods that fuse information from different modalities by a single model, with ML, an ensemble of modality-specific mo…
Histopathology tissue analysis is considered the gold standard in cancer diagnosis and prognosis. Given the large size of these images and the increase in the number of potential cancer cases, an automated solution as an aid to histopathologists is highly desirable. In the recent past, deep learning-based techniques have provided state of the art results in a wide variety of image analysis tasks, including analysis of digitized slides. However, the size of images and variability in histopathology tasks makes it a challenge to develop an integrated framework for histopathology image analysis. W…
A Hyperspectral Imaging Dataset and Methodology for Intraoperative Pixel-Wise Classification of Metastatic Colon Cancer in the Liver
Ruđer Bošković Institute（鲁杰尔·博什科维奇研究所）；Technical University Munich（慕尼黑工业大学）；University of Montreal（蒙特利尔大学）；Photon etc.（Photon etc.公司）；Clinical Hospital Center Zagreb（萨格勒布临床医院中心）；University of Zagreb（萨格勒布大学）；Clinical Hospital Dubrava（杜布拉瓦临床医院）
Rutgers University（罗格斯大学）；Rutgers Robert Wood Johnson Medical School（罗格斯罗伯特·伍德·约翰逊医学院）
Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver diseases (CLD) which can progress to liver cancer. The severity and treatment of NAFLD is determined by NAFLD Activity Scores (NAS)and liver fibrosis stage, which are usually obtained from liver biopsy. However, biopsy is invasive in nature and involves risk of procedural complications. Current methods to predict the fibrosis and NAS scores from noninvasive CT images rely heavily on either a large annotated dataset or transfer learning using pretrained networks. However, the availability of a large anno…
SAS Institute Inc.（SAS研究所公司）；SAS Institute B.V.（SAS研究所私人有限公司）；Amsterdam University Medical Centers（阿姆斯特丹大学医学中心）
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related deaths worldwide. Most CRC deaths are the result of progression of metastases. The assessment of metastases is done using the RECIST criterion, which is time consuming and subjective, as clinicians need to manually measure anatomical tumor sizes. AI has many successes in image object detection, but often suffers because the models used are not interpretable, leading to issues in trust and implementation in the clinical setting. We propose a framework for an AI-augmented system in which an int…
Hybrid deep learning-based strategy for the hepatocellular carcinoma cancer grade classification of H&E stained liver histopathology images
Visvesvaraya National Institute of Technology（维斯瓦拉亚国家理工学院）；AIIMS Nagpur（那格浦尔全印度医学科学研究所）；Indian Institute of Technology Mandi（曼迪印度理工学院）；Universitat de Barcelona（巴塞罗那大学）
Trustworthy Multi-phase Liver Tumor Segmentation via Evidence-based Uncertainty
Southeast University（东南大学）；the First Affiliated Hospital, Zhejiang University School of Medicine（浙江大学医学院附属第一医院）；Zhongda Hospital, School of Medicine, Southeast University（东南大学医学院附属中大医院）
ShanghaiTech University（上海科技大学）；Shanghai United Imaging Intelligence Co., Ltd.（上海联影智能科技有限公司）；Shanghai Clinical Research and Trial Center（上海临床研究中心）
Image registration of liver dynamic contrast-enhanced computed tomography (DCE-CT) is crucial for diagnosis and image-guided surgical planning of liver cancer. However, intensity variations due to the flow of contrast agents combined with complex spatial motion induced by respiration brings great challenge to existing intensity-based registration methods. To address these problems, we propose a novel structure-aware registration method by incorporating structural information of related organs with segmentation-guided deep registration network. Existing segmentation-guided registration methods …
Hunan University of Technology and Business（湖南工商大学）；Utah State University（犹他州立大学）；University of Idaho（爱达荷大学）
Liver segmentation from abdominal CT images is an essential step for liver cancer computer-aided diagnosis and surgical planning. However, both the accuracy and robustness of existing liver segmentation methods cannot meet the requirements of clinical applications. In particular, for the common clinical cases where the liver tissue contains major pathology, current segmentation methods show poor performance. In this paper, we propose a novel low-rank tensor decomposition (LRTD) based multi-atlas segmentation (MAS) framework that achieves accurate and robust pathological liver segmentation of C…
China University of Petroleum（中国石油大学）；Qingdao Municipal Hospital（青岛市市立医院）；University of Chinese Academy of Sciences（中国科学院大学）
Liver cancer is one of the most common malignant diseases in the world. Segmentation and labeling of liver tumors and blood vessels in CT images can provide convenience for doctors in liver tumor diagnosis and surgical intervention. In the past decades, many state-of-the-art medical image segmentation algorithms appeared during this period. With the development of embedded devices, embedded deployment for medical segmentation and automatic reconstruction brings prospects for future automated surgical tasks. Yet, most of the existing segmentation methods mostly care about the spatial feature co…
Huazhong University of Science and Technology（华中科技大学）；The Chinese University of Hong Kong – Shenzhen（香港中文大学（深圳））；Johns Hopkins University（约翰斯·霍普金斯大学）；The First Affiliated Hospital of Nanjing Medical University（南京医科大学第一附属医院）
We demonstrate that AI models can accurately segment liver tumors without the need for manual annotation by using synthetic tumors in CT scans. Our synthetic tumors have two intriguing advantages: (I) realistic in shape and texture, which even medical professionals can confuse with real tumors; (II) effective for training AI models, which can perform liver tumor segmentation similarly to the model trained on real tumors -- this result is exciting because no existing work, using synthetic tumors only, has thus far reached a similar or even close performance to real tumors. This result also impl…
Surgical resections are the most prevalent curative treatment for primary liver cancer. Tumors located in critical positions are known to complexify liver resections (LR). While experienced surgeons in specialized medical centers may have the necessary expertise to accurately anticipate LR complexity, and prepare accordingly, an objective method able to reproduce this behavior would have the potential to improve the standard routine of care, and avoid intra- and postoperative complications. In this article, we propose CoRe, an automated medical image processing pipeline for the prediction of p…
With the injection of contrast material into blood vessels, multi-phase contrasted CT images can enhance the visibility of vessel networks in the human body. Reconstructing the 3D geometric morphology of liver vessels from the contrasted CT images can enable multiple liver preoperative surgical planning applications. Automatic reconstruction of liver vessel morphology remains a challenging problem due to the morphological complexity of liver vessels and the inconsistent vessel intensities among different multi-phase contrasted CT images. On the other side, high integrity is required for the 3D…
Anisotropic Hybrid Networks for liver tumor segmentation with uncertainty quantification
Univ. Grenoble Alpes（格勒诺布尔大学）；Inserm（法国国家健康与医学研究院）；Grenoble Institut Neurosciences（格勒诺布尔神经科学研究所）；Pixyl（Pixyl公司）；Research and Development Laboratory（研发实验室）；Inria（法国国家信息与自动化研究所）；CNRS（法国国家科学研究中心）；Grenoble INP（格勒诺布尔综合理工学院）；LJK（格勒诺布尔大学联合实验室（注：因LJK无明确对应中文通用名称，按原文保留英文缩写））
Yale University（耶鲁大学）；Yale School of Medicine（耶鲁大学医学院）；University of Science and Technology of China（中国科学技术大学）；Suzhou Institute for Advanced Research, University of Science and Technology of China（中国科学技术大学苏州高等研究院）；Chinese Academy of Sciences（中国科学院）
Multimodal image registration has many applications in diagnostic medical imaging and image-guided interventions, such as Transcatheter Arterial Chemoembolization (TACE) of liver cancer guided by intraprocedural CBCT and pre-operative MR. The ability to register peri-procedurally acquired diagnostic images into the intraprocedural environment can potentially improve the intra-procedural tumor targeting, which will significantly improve therapeutic outcomes. However, the intra-procedural CBCT often suffers from suboptimal image quality due to lack of signal calibration for Hounsfield unit, limi…
Queen Mary University of London（伦敦玛丽女王大学）；Communication University of Zhejiang（浙江传媒学院）；University of Leicester（莱斯特大学）
Cancer segmentation in whole-slide images is a fundamental step for viable tumour burden estimation, which is of great value for cancer assessment. However, factors like vague boundaries or small regions dissociated from viable tumour areas make it a challenging task. Considering the usefulness of multi-scale features in various vision-related tasks, we present a structure-aware scale-adaptive feature selection method for efficient and accurate cancer segmentation. Based on a segmentation network with a popular encoder-decoder architecture, a scale-adaptive module is proposed for selecting mor…
PAII Inc.（PAII公司）；Chang Gung Memorial Hospital（长庚纪念医院）；Vanderbilt University（范德堡大学）；PingAn Technology（平安科技）
Ultrasound (US) is a critical modality for diagnosing liver fibrosis. Unfortunately, assessment is very subjective, motivating automated approaches. We introduce a principled deep convolutional neural network (CNN) workflow that incorporates several innovations. First, to avoid overfitting on non-relevant image features, we force the network to focus on a clinical region of interest (ROI), encompassing the liver parenchyma and upper border. Second, we introduce global heteroimage fusion (GHIF), which allows the CNN to fuse features from any arbitrary number of images in a study, increasing its…
James Cook University（詹姆斯·库克大学）；Mahidol University（玛希隆大学）；University of Bremen（不来梅大学）
Automatic segmentation of hepatic lesions in computed tomography (CT) images is a challenging task to perform due to heterogeneous, diffusive shape of tumors and complex background. To address the problem more and more researchers rely on assistance of deep convolutional neural networks (CNN) with 2D or 3D type architecture that have proven to be effective in a wide range of computer vision tasks, including medical image processing. In this technical report, we carry out research focused on more careful approach to the process of learning rather than on complex architecture of the CNN. We have…
Colorectal cancer liver metastases (CLM) are the most common type of distant metastases originating from the abdomen and are characterized by a high recurrence rate after curative resection. It has been previously reported that CLM presenting a low cluster of differentiation 3 (CD3) positive T-cell infiltration density concurrent with a high major histocompatibility complex class I (MHC-I) expression were associated with poor clinical outcomes. In this study, we attempt to noninvasively predict whether a CLM exhibit the CD3LowMHCHigh immunological profile using preoperative CT images. To this …
Università degli Studi di Genova（热那亚大学）；IRCCS San Martino Hospital（IRCCS圣马蒂诺医院）
Due to the need for quick and effective treatments for liver diseases, which are among the most common health problems in the world, staging fibrosis through non-invasive and economic methods has become of great importance. Taking inspiration from diagnostic laparoscopy, used in the past for hepatic diseases, in this paper ultrasound images of the liver are studied, focusing on a specific region of the organ where the Glisson's capsule is visible. In ultrasound images, the Glisson's capsule appears in the shape of a line which can be extracted via classical methods in literature. By making use…
Electron density maps must be accurately estimated to achieve valid dose calculation in MR-only radiotherapy. The goal of this study is to assess whether two deep learning models, the conditional generative adversarial network (cGAN) and the cycle-consistent generative adversarial network (cycleGAN), can generate accurate abdominal synthetic CT (sCT) images from 0.35T MR images for MR-only liver radiotherapy. A retrospective study was performed using CT images and 0.35T MR images of 12 patients with liver (n=8) and non-liver abdominal (n=4) cancer. CT images were deformably registered to the c…
The Ohio State University（俄亥俄州立大学）；IBM Watson Health（IBM沃森健康）；University of York（约克大学）；Stanford University（斯坦福大学）；Harvard University（哈佛大学）；Brigham & Women’s Hospital（布莱根妇女医院）
Radiologists can classify a mammogram as normal or abnormal at better than chance levels after less than a second's exposure to the images. In this work, we combine these radiologists' gist inputs into pre-trained machine learning models to validate that integrating gist with a CNN model can achieve an AUC (area under the curve) statistically significantly higher than either the gist perception of radiologists or the model without gist input.
Otto von Guericke University（奥托·冯·格里克大学）；German Center for Neurodegenerative Disease（德国神经退行性疾病中心）；Center for Behavioral Brain Sciences（行为脑科学中心）；Leibniz Institute for Neurobiology（莱布尼茨神经生物学研究所）
Segmentation of biomedical images can assist radiologists to make a better diagnosis and take decisions faster by helping in the detection of abnormalities, such as tumors. Manual or semi-automated segmentation, however, can be a time-consuming task. Most deep learning based automated segmentation methods are supervised and rely on manually segmented ground-truth. A possible solution for the problem would be an unsupervised deep learning based approach for automated segmentation, which this research work tries to address. We use a W-Net architecture and modified it, such that it can be applied…
Accurate segmentation of the liver is a prerequisite for the diagnosis of disease. Automated segmentation is an important application of computer-aided detection and diagnosis of liver disease. In recent years, automated processing of medical images has gained breakthroughs. However, the low contrast of abdominal scan CT images and the complexity of liver morphology make accurate automatic segmentation challenging. In this paper, we propose RA V-Net, which is an improved medical image automatic segmentation model based on U-Net. It has the following three main innovations. CofRes Module (Compo…
Slovak University of Technology（斯洛伐克工业大学）；Institute for Clinical and Experimental Medicine（临床与实验医学研究所）；Charles University（查理大学）；Thomayer University Hospital（托马耶大学医院）
Prevention and early diagnosis of breast cancer (BC) is an essential prerequisite for the selection of proper treatment. The substantial pressure due to the increase of demand for faster and more precise diagnostic results drives for automatic solutions. In the past decade, deep learning techniques have demonstrated their power over several domains, and Computer-Aided (CAD) diagnostic became one of them. However, when it comes to the analysis of Whole Slide Images (WSI), most of the existing works compute predictions from levels independently. This is, however, in contrast to the histopatholog…
Korea Advanced Institute of Science and Technology（韩国科学技术院）；University of Ulsan College of Medicine（蔚山大学医学院）；Asan Medical Center（峨山医学中心）
Medical image registration is one of the key processing steps for biomedical image analysis such as cancer diagnosis. Recently, deep learning based supervised and unsupervised image registration methods have been extensively studied due to its excellent performance in spite of ultra-fast computational time compared to the classical approaches. In this paper, we present a novel unsupervised medical image registration method that trains deep neural network for deformable registration of 3D volumes using a cycle-consistency. Thanks to the cycle consistency, the proposed deep neural networks can t…
This paper presents U-net based breast cancer metastases detection and classification in lymph nodes, as well as patient-level classification based on metastases detection. The whole pipeline can be divided into five steps: preprocessing and data argumentation, patch-based segmentation, post processing, slide-level classification, and patient-level classification. In order to reduce overfitting and speedup convergence, we applied batch normalization and dropout into U-Net. The final Kappa score reaches 0.902 on training data.
AI in Oncology: Transforming Cancer Detection through Machine Learning and Deep Learning Applications
School of Basic Medical Sciences, Zhengzhou University（郑州大学基础医学院）；School of Electrical and Information Engineering, Zhengzhou University（郑州大学电气与信息工程学院）；Academy of Medical Sciences, Zhengzhou University（郑州大学医学科学院）；China-US (Henan) Hormel Cancer Institute（中美（河南）荷美尔肿瘤研究院）；The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital（郑州大学附属肿瘤医院 河南省肿瘤医院）；State Key Laboratory of Esophageal Cancer Prevention and Treatment（食管癌防治国家重点实验室）；The Collaborative Innovation Center of Henan Province for Cancer Chemoprevention（河南省癌症化预防协同创新中心）
