在动态稳态中模拟简单上皮的真实3D变形
Modelling realistic 3D deformations of simple epithelia in dynamic homeostasis
摘要：
在动态内环境稳定期间组织和器官结构的维持常常不被很好地理解。为了使系统稳定，细胞更新、细胞迁移和细胞死亡必须精细地平衡。此外，组织的形状必须保持相对不变。简单的上皮组织存在于整个身体的各种结构中，例如内皮、间皮、肺的衬里、唾液和甲状腺以及胃肠道。尽管简单的上皮组织普遍存在，但很少有模型准确描述这些组织如何保持稳定的结构。在这里，我们提出了一种新的，三维，可变形，多层，细胞中心模型的一个简单的上皮。细胞运动受上皮弯曲电位、细胞-细胞黏附和粘性效应的最小化控制。我们表明，该模型是能够保持一致的组织结构，同时进行自我更新。我们还证明了模型的鲁棒性下的组织更新，细胞迁移和细胞去除。这里提出的模型是一个有价值的进步，对复杂和广义结构的组织和器官的建模。
英文摘要：
The maintenance of tissue and organ structures during dynamic homeostasis is often not well understood. In order for a system to be stable, cell renewal, cell migration and cell death must be finely balanced. Moreover, a tissue's shape must remain relatively unchanged. Simple epithelial tissues occur in various structures throughout the body, such as the endothelium, mesothelium, linings of the lungs, saliva and thyroid glands, and gastrointestinal tract. Despite the prevalence of simple epithelial tissues, there are few models which accurately describe how these tissues maintain a stable structure. Here, we present a novel, 3D, deformable, multilayer, cell-centre model of a simple epithelium. Cell movement is governed by the minimisation of a bending potential across the epithelium, cell-cell adhesion, and viscous effects. We show that the model is capable of maintaining a consistent tissue structure while undergoing self renewal. We also demonstrate the model's robustness under tissue renewal, cell migration and cell removal. The model presented here is a valuable advancement towards the modelling of tissues and organs with complex and generalised structures.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
