与拓扑缺陷逾渗相关的可变形活性胞的胞形转变
Active Deformable Cells Undergo Cell Shape Transition Associated with Percolation of Topological Defects
摘要：
细胞变形性是组织尺度力学性质（如流动性和刚性）的重要决定因素，因此对于理解组织稳态和稳定发育过程至关重要。然而，数值模拟的集体动力学的细胞仲裁细胞变形类似于间充质，阿米巴样，上皮细胞在非融合的情况下需要高的计算成本，仍然是具有挑战性的。在这里，我们提出了一种新的方法，使我们能够研究比现有方法更大数量的细胞。使用该方法，我们研究了密集的活性细胞群体通过排除体积相互作用相互作用，并发现了两个流体相的出现在可变形的细胞群体中，一个软流体相与急剧变形的细胞形状和一个流体相与圆形细胞形状。这两个阶段之间的过渡的特点是渗透的拓扑缺陷，这是实验测试。
英文摘要：
Cell deformability is an essential determinant for tissue-scale mechanical nature, such as fluidity and rigidity, and is thus crucial for understanding tissue homeostasis and stable developmental processes. However, numerical simulations for the collective dynamics of cells with arbitral cell deformations akin to mesenchymal, ameboid, and epithelial cells in a non-confluent situation need high computational costs and are still challenging. Here we propose a new method that allows us to study significantly larger numbers of cells than existing methods. Using the method, we investigated the densely packed active cell population interacting via excluded volume interactions, and discovered the emergence of two fluid phases in deformable cell populations, a soft-fluid phase with drastically deformed cell shapes and a fluid phase with circular cell shapes. The transition between these two phases is characterized by the percolation of topological defects, which is experimentally testable.
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