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arXiv 2202.06159q-bio.NCcs.LG
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通过无监督域自适应的神经元群体活动的跨会话记录的鲁棒对齐

Robust alignment of cross-session recordings of neural population activity by behaviour via unsupervised domain adaptation

University of Edinburgh(爱丁堡大学);Icahn School of Medicine at Mount Sinai(西奈山伊坎医学院)

Justin Jude, Matthew G Perich, Lee E Miller, Matthias H Hennig

摘要:

与行为相关的神经元群体活动被假定为固有的低维,尽管观察到使用多电极阵列记录的数据的高维性。因此,从神经元群体记录预测行为已被证明是最有效的,当使用潜变量模型。然而,随着时间的推移,单个神经元的活动可以漂移,并且由于植入的神经探针的移动,不同的神经元将被记录。这意味着一个被训练来预测某一天行为的解码器在另一天测试时表现更差。另一方面,有证据表明,行为背后的潜在动力甚至可能在数月或数年内保持稳定。基于这一想法,我们引入了一个模型,能够推断行为相关的潜在动态从以前看不见的数据记录从同一个动物,而不需要解码器重新校准。我们表明,无监督域自适应结合顺序变分自动编码器,在几个会话上训练,可以实现良好的泛化到看不见的数据,并正确预测传统方法失败的行为。我们的研究结果进一步支持了这一假设,即行为相关的神经动力学是低维的,随着时间的推移是稳定的,并将使更有效和灵活地使用脑机接口技术。

英文摘要:

Neural population activity relating to behaviour is assumed to be inherently low-dimensional despite the observed high dimensionality of data recorded using multi-electrode arrays. Therefore, predicting behaviour from neural population recordings has been shown to be most effective when using latent variable models. Over time however, the activity of single neurons can drift, and different neurons will be recorded due to movement of implanted neural probes. This means that a decoder trained to predict behaviour on one day performs worse when tested on a different day. On the other hand, evidence suggests that the latent dynamics underlying behaviour may be stable even over months and years. Based on this idea, we introduce a model capable of inferring behaviourally relevant latent dynamics from previously unseen data recorded from the same animal, without any need for decoder recalibration. We show that unsupervised domain adaptation combined with a sequential variational autoencoder, trained on several sessions, can achieve good generalisation to unseen data and correctly predict behaviour where conventional methods fail. Our results further support the hypothesis that behaviour-related neural dynamics are low-dimensional and stable over time, and will enable more effective and flexible use of brain computer interface technologies.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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