未经处理的实体瘤生长过程中表面电荷密度变化的模拟
Simulations of surface charge density changes during the untreated solid tumor growth
摘要：
了解未经治疗的肿瘤生长动力学及其内在的发现是有趣和有趣的。本研究的目的是提出一个近似的分析表达式，允许模拟未经治疗的实体瘤生长过程中，在癌症周围的健康组织界面的表面电荷密度变化的变化。为此，使用Gompertz和Poisson方程。模拟显示，未受干扰的实体肿瘤生长与肿瘤和周围健康组织之间的表面电荷密度随时间的变化密切相关。此外，未受干扰的实体瘤生长受该表面电荷密度的时间变化支配。可以得出结论，图形策略证实了未经治疗的癌症的电参数和生理参数之间的对应关系，这可能在其生长，进展，转移和保护免受免疫系统攻击和抗癌治疗中起着至关重要的作用。此外，当考虑到化学疗法和免疫疗法中的分子的极性重新设计它们时，癌症周围健康组织界面处的表面电荷密度变化的知识可能是相关的。在设计全新的疗法时也是如此。
英文摘要：
Understanding the untreated tumor growth kinetics and its intrinsic findings is interesting and intriguing. The aim of this study is to propose an approximate analytical expression that allows to simulate changes in surface charge density changes at cancer-surrounding healthy tissue interface during the untreated solid tumor growth. For this, the Gompertz and Poisson equations are used. Simulations reveal that the unperturbed solid tumor growth is closely related to changes in the surface charge density over time between the tumor and the surrounding healthy tissue. Furthermore, the unperturbed solid tumor growth is governed by temporal changes in this surface charge density. It is concluded that graphic strategies corroborate the correspondence between the electrical and physiological parameters in the untreated cancer, which may have an essential role in its growth, progression, metastasis and protection against immune system attack and anti-cancer therapies. In addition, the knowledge of surface charge density changes at cancer-surrounding healthy tissue interface may be relevant when redesigning the molecules in chemotherapy and immunotherapy taking into account their polarities. This can also be true in the design of completely novel therapies.
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