Real-time automatic polyp detection in colonoscopy using feature enhancement module and spatiotemporal similarity correlation unit
Shanghai Jiao Tong University（上海交通大学）；Renji Hospital, School of Medicine, Shanghai Jiao Tong University（上海交通大学医学院附属仁济医院）；Deepwise Artificial Intelligence Laboratory（深睿人工智能实验室）
Jianwei Xu, Ran Zhao, Yizhou Yu, Qingwei Zhang, Xianzhang Bian, Jun Wang, Zhizheng Ge, Dahong Qian
备注：
This paper has been accepted by Biomedical Signal Processing and Control. Please cite the paper as Xu, J., Zhao, R., Yu, Y., Zhang, Q., Bian, X., Wang, J., Ge, Z., Qian, D., 2021. Real-time automatic polyp detection in colonoscopy using feature enhancement module and spatiotemporal similarity correlation unit. Biomedical Signal Processing and Control 66, 102503
发表信息：
Biomedical Signal Processing and Control, vol. 66, p. 102503, Apr. 2021
Automatic detection of polyps is challenging because different polyps vary greatly, while the changes between polyps and their analogues are small. The state-of-the-art methods are based on convolutional neural networks (CNNs). However, they may fail due to lack of training data, resulting in high rates of missed detection and false positives (FPs). In order to solve these problems, our method combines the two-dimensional (2-D) CNN-based real-time object detector network with spatiotemporal information. Firstly, we use a 2-D detector network to detect static images and frames, and based on the detector network, we propose two feature enhancement modules-the FP Relearning Module (FPRM) to make the detector network learning more about the features of FPs for higher precision, and the Image Style Transfer Module (ISTM) to enhance the features of polyps for sensitivity improvement. In video detection, we integrate spatiotemporal information, which uses Structural Similarity (SSIM) to measure the similarity between video frames. Finally, we propose the Inter-frame Similarity Correlation Unit (ISCU) to combine the results obtained by the detector network and frame similarity to make the final decision. We verify our method on both private databases and publicly available databases. Experimental results show that these modules and units provide a performance improvement compared with the baseline method. Comparison with the state-of-the-art methods shows that the proposed method outperforms the existing ones which can meet real-time constraints. It's demonstrated that our method provides a performance improvement in sensitivity, precision and specificity, and has great potential to be applied in clinical colonoscopy.
We present a neural network architecture for medical image segmentation of diabetic foot ulcers and colonoscopy polyps. Diabetic foot ulcers are caused by neuropathic and vascular complications of diabetes mellitus. In order to provide a proper diagnosis and treatment, wound care professionals need to extract accurate morphological features from the foot wounds. Using computer-aided systems is a promising approach to extract related morphological features and segment the lesions. We propose a convolution neural network called HarDNet-DFUS by enhancing the backbone and replacing the decoder of …
Department Of Computer Science University of Massachusetts Lowell（马萨诸塞大学洛厄尔分校计算机科学系）
Colorectal cancer (CRC) is a common and lethal disease. Globally, CRC is the third most commonly diagnosed cancer in males and the second in females. For colorectal cancer, the best screening test available is the colonoscopy. During a colonoscopic procedure, a tiny camera at the tip of the endoscope generates a video of the internal mucosa of the colon. The video data are displayed on a monitor for the physician to examine the lining of the entire colon and check for colorectal polyps. Detection and removal of colorectal polyps are associated with a reduction in mortality from colorectal canc…
University of Cambridge（剑桥大学）；Cancer Research UK Cambridge Centre（英国癌症研究中心剑桥中心）
Background: Colonoscopy remains the gold-standard screening for colorectal cancer. However, significant miss rates for polyps have been reported, particularly when there are multiple small adenomas. This presents an opportunity to leverage computer-aided systems to support clinicians and reduce the number of polyps missed. Method: In this work we introduce the Focus U-Net, a novel dual attention-gated deep neural network, which combines efficient spatial and channel-based attention into a single Focus Gate module to encourage selective learning of polyp features. The Focus U-Net further incorp…
TSdetector: Temporal-Spatial Self-correction Collaborative Learning for Colonoscopy Video Detection
School of Biological Science and Medical Engineering, Southeast University（东南大学生物科学与医学工程学院）；Jiangsu Key Laboratory of Biomaterials and Devices, Southeast University（东南大学江苏省生物材料与器件重点实验室）；TUGE Healthcare（图格医疗）；Institute of Medical Technology, Peking University Health Science Center（北京大学医学部医学技术研究院）；Laboratory of Image Science and Technology, Southeast University（东南大学图像科学与技术实验室）；Key Laboratory of Computer Network and Information Integration, Southeast University（东南大学计算机网络和信息集成重点实验室）；Department of Computer and Data Science and Department of Biomedical Engineering, Case Western Reserve University（凯斯西储大学计算机与数据科学系及生物医学工程系）
SimulaMet；UiT The Arctic University of Norway（挪威北极大学）；Oslo Metropolitan University（奥斯陆城市大学）；Institute of Biomedical Engineering, University of Oxford（牛津大学生物医学工程研究所）；Bærum Hospital（贝鲁姆医院）；Augere Medical AS（Augere Medical 公司）；Sahlgrenska University Hospital-Mölndal Hospital（萨尔格伦斯卡大学医院-默恩达尔医院）；Sahlgrenska Academy, University of Gothenburg（哥德堡大学萨尔格伦斯卡学院）
Deep learning in gastrointestinal endoscopy can assist to improve clinical performance and be helpful to assess lesions more accurately. To this extent, semantic segmentation methods that can perform automated real-time delineation of a region-of-interest, e.g., boundary identification of cancer or precancerous lesions, can benefit both diagnosis and interventions. However, accurate and real-time segmentation of endoscopic images is extremely challenging due to its high operator dependence and high-definition image quality. To utilize automated methods in clinical settings, it is crucial to de…
Purpose: Colorectal cancer (CRC) is the second most common cause of cancer mortality worldwide. Colonoscopy is a widely used technique for colon screening and polyp lesions diagnosis. Nevertheless, manual screening using colonoscopy suffers from a substantial miss rate of polyps and is an overwhelming burden for endoscopists. Computer-aided diagnosis (CAD) for polyp detection has the potential to reduce human error and human burden. However, current polyp detection methods based on object detection framework need many handcrafted pre-processing and post-processing operations or user guidance t…
Validating polyp and instrument segmentation methods in colonoscopy through Medico 2020 and MedAI 2021 Challenges
Northwestern University（西北大学）；Jadavpur University（贾达普大学）；Technische Universität Hamburg（汉堡工业大学）；SimulaMet（西穆拉梅特研究所）；Julius-Maximilian University of Würzburg（维尔茨堡大学）；Australian National University（澳大利亚国立大学）；Gachon University（嘉泉大学）；University of Oxford（牛津大学）；University of Bergen（卑尔根大学）；University of Oslo（奥斯陆大学）；Swedish Medical Center（瑞典医疗中心）；National University of Computer and Emerging Sciences（国家计算机与新兴科学大学）；University of Science, VNU-HCM（胡志明市国家大学科学大学）
Xi’an Jiaotong-Liverpool University（西交利物浦大学）；University of Liverpool（利物浦大学）
Colonoscopy, currently the most efficient and recognized colon polyp detection technology, is necessary for early screening and prevention of colorectal cancer. However, due to the varying size and complex morphological features of colonic polyps as well as the indistinct boundary between polyps and mucosa, accurate segmentation of polyps is still challenging. Deep learning has become popular for accurate polyp segmentation tasks with excellent results. However, due to the structure of polyps image and the varying shapes of polyps, it easy for existing deep learning models to overfitting the c…
We present a computer-aided detection algorithm for polyps in optical colonoscopy images. Polyps are the precursors to colon cancer. In the US alone, more than 14 million optical colonoscopies are performed every year, mostly to screen for polyps. Optical colonoscopy has been shown to have an approximately 25% polyp miss rate due to the convoluted folds and bends present in the colon. In this work, we present an automatic detection algorithm to detect these polyps in the optical colonoscopy images. We use a machine learning algorithm to infer a depth map for a given optical colonoscopy image a…
School of Electronic and Computer Engineering, Peking University（北京大学电子与计算机工程学院）；Aberdeen Institute of Data Science and Artificial Intelligence, South China Normal University（华南师范大学阿伯丁数据科学与人工智能学院）
University of Lincoln（林肯大学）；Lingnan Normal University（岭南师范学院）
Besides the complex nature of colonoscopy frames with intrinsic frame formation artefacts such as light reflections and the diversity of polyp types/shapes, the publicly available polyp segmentation training datasets are limited, small and imbalanced. In this case, the automated polyp segmentation using a deep neural network remains an open challenge due to the overfitting of training on small datasets. We proposed a simple yet effective polyp segmentation pipeline that couples the segmentation (FCN) and classification (CNN) tasks. We find the effectiveness of interactive weight transfer betwe…
University of Massachusetts Lowell（马萨诸塞大学洛厄尔分校）；Xiangya Hospital of Central South University（中南大学湘雅医院）
Colorectal polyps are abnormal tissues growing on the intima of the colon or rectum with a high risk of developing into colorectal cancer, the third leading cause of cancer death worldwide. Early detection and removal of colon polyps via colonoscopy have proved to be an effective approach to prevent colorectal cancer. Recently, various CNN-based computer-aided systems have been developed to help physicians detect polyps. However, these systems do not perform well in real-world colonoscopy operations due to the significant difference between images in a real colonoscopy and those in the public …
Colonoscopy is widely recognised as the gold standard procedure for the early detection of colorectal cancer (CRC). Segmentation is valuable for two significant clinical applications, namely lesion detection and classification, providing means to improve accuracy and robustness. The manual segmentation of polyps in colonoscopy images is time-consuming. As a result, the use of deep learning (DL) for automation of polyp segmentation has become important. However, DL-based solutions can be vulnerable to overfitting and the resulting inability to generalise to images captured by different colonosc…
The University of Adelaide（阿德莱德大学）；South Australian Health and Medical Research Institute（南澳大利亚健康与医学研究所）；Nagoya University（名古屋大学）
Anomaly detection methods generally target the learning of a normal image distribution (i.e., inliers showing healthy cases) and during testing, samples relatively far from the learned distribution are classified as anomalies (i.e., outliers showing disease cases). These approaches tend to be sensitive to outliers that lie relatively close to inliers (e.g., a colonoscopy image with a small polyp). In this paper, we address the inappropriate sensitivity to outliers by also learning from inliers. We propose a new few-shot anomaly detection method based on an encoder trained to maximise the mutua…
Virtual colonoscopy (VC) allows a radiologist to navigate through a 3D colon model reconstructed from a computed tomography scan of the abdomen, looking for polyps, the precursors of colon cancer. Polyps are seen as protrusions on the colon wall and haustral folds, visible in the VC fly-through videos. A complete review of the colon surface requires full navigation from the rectum to the cecum in antegrade and retrograde directions, which is a tedious task that takes an average of 30 minutes. Crowdsourcing is a technique for non-expert users to perform certain tasks, such as image or video ann…
Convolutional Neural Networks (CNNs) are propelling advances in a range of different computer vision tasks such as object detection and object segmentation. Their success has motivated research in applications of such models for medical image analysis. If CNN-based models are to be helpful in a medical context, they need to be precise, interpretable, and uncertainty in predictions must be well understood. In this paper, we develop and evaluate recent advances in uncertainty estimation and model interpretability in the context of semantic segmentation of polyps from colonoscopy images. We evalu…
SimulaMet（西穆拉梅特研究所）；UIT The Arctic University of Norway（挪威北极大学）；Augere Medical AS（奥热医疗公司）；University of Oslo（奥斯陆大学）；Kristiania University College（克里斯蒂安尼亚大学学院）；Oslo Metropolitan University（奥斯陆城市大学）；Oslo University Hospital（奥斯陆大学医院）
Pixel-wise image segmentation is a highly demanding task in medical-image analysis. In practice, it is difficult to find annotated medical images with corresponding segmentation masks. In this paper, we present Kvasir-SEG: an open-access dataset of gastrointestinal polyp images and corresponding segmentation masks, manually annotated by a medical doctor and then verified by an experienced gastroenterologist. Moreover, we also generated the bounding boxes of the polyp regions with the help of segmentation masks. We demonstrate the use of our dataset with a traditional segmentation approach and …
Shenzhen Research Institute of Big Data（深圳大数据研究院）；Sun Yat-sen University（中山大学）；The Chinese University of Hong Kong(Shenzhen)（香港中文大学（深圳））；Longgang District People’s Hospital of Shenzhen（深圳市龙岗区人民医院）
Differentiation of colorectal polyps is an important clinical examination. A computer-aided diagnosis system is required to assist accurate diagnosis from colonoscopy images. Most previous studies at-tempt to develop models for polyp differentiation using Narrow-Band Imaging (NBI) or other enhanced images. However, the wide range of these models' applications for clinical work has been limited by the lagging of imaging techniques. Thus, we propose a novel framework based on a teacher-student architecture for the accurate colorectal polyp classification (CPC) through directly using white-light …
University College London（伦敦大学学院）；University College Hospital（伦敦大学学院医院）
Potentially precancerous polyps detected with CT colonography (CTC) need to be removed subsequently, using an optical colonoscope (OC). Due to large colonic deformations induced by the colonoscope, even very experienced colonoscopists find it difficult to pinpoint the exact location of the colonoscope tip in relation to polyps reported on CTC. This can cause unduly prolonged OC examinations that are stressful for the patient, colonoscopist and supporting staff. We developed a method, based on monocular 3D reconstruction from OC images, that automatically matches polyps observed in OC with poly…
Instituto de Ingeniería Eléctrica, Universidad de la República（共和国大学电气工程研究所）；Duke University（杜克大学）
Computer tomographic colonography, combined with computer-aided detection, is a promising emerging technique for colonic polyp analysis. We present a complete pipeline for polyp detection, starting with a simple colon segmentation technique that enhances polyps, followed by an adaptive-scale candidate polyp delineation and classification based on new texture and geometric features that consider both the information in the candidate polyp location and its immediate surrounding area. The proposed system is tested with ground truth data, including flat and small polyps which are hard to detect ev…
SimulaMet；UiT The Arctic University of Norway（挪威北极大学）；University of Oxford（牛津大学）；Oxford NIHR Biomedical Research Centre（牛津NIHR生物医学研究中心）；Oslo Metropolitan University（奥斯陆城市大学）
Computer-aided detection, localisation, and segmentation methods can help improve colonoscopy procedures. Even though many methods have been built to tackle automatic detection and segmentation of polyps, benchmarking of state-of-the-art methods still remains an open problem. This is due to the increasing number of researched computer vision methods that can be applied to polyp datasets. Benchmarking of novel methods can provide a direction to the development of automated polyp detection and segmentation tasks. Furthermore, it ensures that the produced results in the community are reproducible…
PolypDB: A Curated Multi-Center Dataset for Development of AI Algorithms in Colonoscopy
Northwestern University（西北大学）；Sahlgrenska University Hospital（萨尔格伦斯卡大学医院）；The University of Gothenburg（哥德堡大学）；Harvard University（哈佛大学）；University Hospital Würzburg（维尔茨堡大学医院）；Hanoi Medical University（河内医科大学）；The Institute of Gastroenterology and Hepatology, Hanoi, Vietnam（越南河内胃肠病与肝病研究所）；Ho Chi Minh University Medical Center（胡志明市大学医疗中心）
本文发布涵盖三国三中心、五种成像模态的 3934 张息肉图像数据集 PolypDB，并提供分割、检测与联邦学习基准，以支持结肠镜 AI 算法开发。
Fudan University（复旦大学）；Inception Institute of Artificial Intelligence（Inception人工智能研究院）；Huashan Hospital（华山医院）
Automatic colorectal polyp detection in colonoscopy video is a fundamental task, which has received a lot of attention. Manually annotating polyp region in a large scale video dataset is time-consuming and expensive, which limits the development of deep learning techniques. A compromise is to train the target model by using labeled images and infer on colonoscopy videos. However, there are several issues between the image-based training and video-based inference, including domain differences, lack of positive samples, and temporal smoothness. To address these issues, we propose an Image-video-…
Real-time and robust automatic detection of polyps from colonoscopy videos are essential tasks to help improve the performance of doctors during this exam. The current focus of the field is on the development of accurate but inefficient detectors that will not enable a real-time application. We advocate that the field should instead focus on the development of simple and efficient detectors that an be combined with effective trackers to allow the implementation of real-time polyp detectors. In this paper, we propose a Kalman filtering tracker that can work together with powerful, but efficient…
Computer Vision Center（计算机视觉中心）；Universitat Autonoma de Barcelona（巴塞罗那自治大学）；Montreal Institute for Learning Algorithms（蒙特利尔学习算法研究所）；Université de Montréal（蒙特利尔大学）；École Polytechnique de Montréal（蒙特利尔理工学院）；Hospital Clinic（临床医院）；Universidad de Barcelona（巴塞罗那大学）；Imagia Inc.（Imagia公司）
Colorectal cancer (CRC) is the third cause of cancer death worldwide. Currently, the standard approach to reduce CRC-related mortality is to perform regular screening in search for polyps and colonoscopy is the screening tool of choice. The main limitations of this screening procedure are polyp miss-rate and inability to perform visual assessment of polyp malignancy. These drawbacks can be reduced by designing Decision Support Systems (DSS) aiming to help clinicians in the different stages of the procedure by providing endoluminal scene segmentation. Thus, in this paper, we introduce an extend…
The University of Kansas（堪萨斯大学）；The University of Kansas Medical Center（堪萨斯大学医学中心）；Washington University School of Medicine（华盛顿大学医学院）；Ryerson University（瑞尔森大学）
Colorectal cancer (CRC) is one of the most common types of cancer with a high mortality rate. Colonoscopy is the preferred procedure for CRC screening and has proven to be effective in reducing CRC mortality. Thus, a reliable computer-aided polyp detection and classification system can significantly increase the effectiveness of colonoscopy. In this paper, we create an endoscopic dataset collected from various sources and annotate the ground truth of polyp location and classification results with the help of experienced gastroenterologists. The dataset can serve as a benchmark platform to trai…
RIGS-Refiner: Risk-Guided Recursive Refinement in Prediction Space for Colonoscopy Polyp Segmentation
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；South China University of Technology（华南理工大学）；CyPhi( Ψ Φ \Psi\Phi ) AI Research Lab, School of IT, Monash University Malaysia（马来西亚莫纳什大学信息技术学院CyPhi( Ψ Φ \Psi\Phi )人工智能研究实验室）
SALI: Short-term Alignment and Long-term Interaction Network for Colonoscopy Video Polyp Segmentation
Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology（华中科技大学武汉光电国家研究中心）；School of Engineering and Science, Huazhong University of Science and Technology（华中科技大学工程科学学院）；Huazhong University of Science and Technology Tongji Medical College（华中科技大学同济医学院）
Contrastive Learning under Noisy Temporal Self-Supervision for Colonoscopy Videos
Department of Mathematics, University of Padova, Padova, Italy（帕多瓦大学数学系）；LTCI, Telecom Paris, Institut Polytechnique de Paris, Palaiseau, France（巴黎电信学院）；Cosmo Intelligent Medical Devices, Dublin, Ireland（都柏林智能医疗设备公司）
SimulaMet（西姆拉大都会研究所）；Augere Medical AS（奥格医疗公司）；UiT The Arctic University of Norway（挪威UiT北极大学）；University of Oslo（奥斯陆大学）；Oslo Metropolitan University（奥斯陆城市大学）
Accurate computer-aided polyp detection and segmentation during colonoscopy examinations can help endoscopists resect abnormal tissue and thereby decrease chances of polyps growing into cancer. Towards developing a fully automated model for pixel-wise polyp segmentation, we propose ResUNet++, which is an improved ResUNet architecture for colonoscopic image segmentation. Our experimental evaluations show that the suggested architecture produces good segmentation results on publicly available datasets. Furthermore, ResUNet++ significantly outperforms U-Net and ResUNet, two key state-of-the-art d…
Università di Bologna（博洛尼亚大学）；University of Padua（帕多瓦大学）
Semantic segmentation has a wide array of applications ranging from medical-image analysis, scene understanding, autonomous driving and robotic navigation. This work deals with medical image segmentation and in particular with accurate polyp detection and segmentation during colonoscopy examinations. Several convolutional neural network architectures have been proposed to effectively deal with this task and with the problem of segmenting objects at different scale input. The basic architecture in image segmentation consists of an encoder and a decoder: the first uses convolutional filters to e…
Temporally-Aware Supervised Contrastive Learning for Polyp Counting in Colonoscopy
Department of Mathematics, University of Padova, Padova, Italy（帕多瓦大学数学系）；Cosmo Intelligent Medical Devices, Dublin, Ireland（科莫智能医疗设备公司）；Milan Center for Neuroscience, University of Milano–Bicocca, Milan, Italy（米兰神经科学中心）
University of Adelaide（阿德莱德大学）；Australian Institute for Machine Learning（澳大利亚机器学习研究所）；South Australian Health and Medical Research Institute（南澳大利亚健康与医学研究所）；Nagoya University（名古屋大学）
The automatic detection of frames containing polyps from a colonoscopy video sequence is an important first step for a fully automated colonoscopy analysis tool. Typically, such detection system is built using a large annotated data set of frames with and without polyps, which is expensive to be obtained. In this paper, we introduce a new system that detects frames containing polyps as anomalies from a distribution of frames from exams that do not contain any polyps. The system is trained using a one-class training set consisting of colonoscopy frames without polyps -- such training set is con…
Australian Institute for Machine Learning, University of Adelaide（阿德莱德大学澳大利亚机器学习研究所）；South Australian Health and Medical Research Institute（南澳大利亚健康与医学研究所）；Austin Health（奥斯汀健康中心）；Lyell McEwin Hospital（莱尔麦克尤恩医院）
In this paper, we propose and analyse a system that can automatically detect, localise and classify polyps from colonoscopy videos. The detection of frames with polyps is formulated as a few-shot anomaly classification problem, where the training set is highly imbalanced with the large majority of frames consisting of normal images and a small minority comprising frames with polyps. Colonoscopy videos may contain blurry images and frames displaying feces and water jet sprays to clean the colon -- such frames can mistakenly be detected as anomalies, so we have implemented a classifier to reject…
Large Language Model Evaluated Stand-alone Attention-Assisted Graph Neural Network with Spatial and Structural Information Interaction for Precise Endoscopic Image Segmentation
Department of Mathematics, The Chinese University of Hong Kong（香港中文大学数学系）；Department of Electronic and Computer Engineering, University of Massachusetts, Lowell（马萨诸塞大学低罗分校电子与计算机工程系）；Department of Radiology, Northwestern University（西北大学放射科）
Computerized detection of colonic polyps remains an unsolved issue because of the wide variation in the appearance, texture, color, size, and presence of the multiple polyp-like imitators during colonoscopy. In this paper, we propose a deep convolutional neural network based model for the computerized detection of polyps within colonoscopy images. The proposed model comprises 16 convolutional layers with 2 fully connected layers, and a Softmax layer, where we implement a unique approach using different convolutional kernels within the same hidden layer for deeper feature extraction. We applied…
WSPolypNet: Weakly Supervised Polyp Localization in Colonoscopy Videos
Soonchunhyang University（顺天乡大学）；Seoul National University（首尔大学）；Kyungpook National University（庆北国立大学）；OUTTA；Chung-Ang University（中央大学）；Samsung Changwon Hospital（三星昌原医院）；NVIDIA AI Technology Center（英伟达人工智能技术中心）
