Realistic Endoscopic Image Generation Method Using Virtual-to-real Image-domain Translation
Nagoya University（名古屋大学）；Kyoto Second Red Cross Hospital（京都第二红十字医院）；Sapporo-Minami-Sanjo Hospital（札幌南三条医院）；Sapporo-Kosei General Hospital（札幌厚生综合医院）；Keiwakai Nishioka Hospital（惠和会西冈医院）；National Institute of Informatics（国立信息学研究所）
This paper proposes a realistic image generation method for visualization in endoscopic simulation systems. Endoscopic diagnosis and treatment are performed in many hospitals. To reduce complications related to endoscope insertions, endoscopic simulation systems are used for training or rehearsal of endoscope insertions. However, current simulation systems generate non-realistic virtual endoscopic images. To improve the value of the simulation systems, improvement of reality of their generated images is necessary. We propose a realistic image generation method for endoscopic simulation systems. Virtual endoscopic images are generated by using a volume rendering method from a CT volume of a patient. We improve the reality of the virtual endoscopic images using a virtual-to-real image-domain translation technique. The image-domain translator is implemented as a fully convolutional network (FCN). We train the FCN by minimizing a cycle consistency loss function. The FCN is trained using unpaired virtual and real endoscopic images. To obtain high quality image-domain translation results, we perform an image cleansing to the real endoscopic image set. We tested to use the shallow U-Net, U-Net, deep U-Net, and U-Net having residual units as the image-domain translator. The deep U-Net and U-Net having residual units generated quite realistic images.
University of Salzburg（萨尔茨堡大学）；St. Anna Children’s Hospital（圣安娜儿童医院）；Salzburg University of Applied Sciences（萨尔茨堡应用科学大学）
Novel imaging technologies raise many questions concerning the adaptation of computer-aided decision support systems. Classification models either need to be adapted or even newly trained from scratch to exploit the full potential of enhanced techniques. Both options typically require the acquisition of new labeled training data. In this work we investigate the applicability of image-to-image translation to endoscopic images showing different imaging modalities, namely conventional white-light and narrow-band imaging. In a study on computer-aided celiac disease diagnosis, we explore whether im…
University of Washington（华盛顿大学）；Institute of Automation, Chinese Academy of Sciences（中国科学院自动化研究所）；Rochester Institute of Technology（罗切斯特理工学院）
Intelligent vision is appealing in computer-assisted and robotic surgeries. Vision-based analysis with deep learning usually requires large labeled datasets, but manual data labeling is expensive and time-consuming in medical problems. We investigate a novel cross-domain strategy to reduce the need for manual data labeling by proposing an image-to-image translation model live-cadaver GAN (LC-GAN) based on generative adversarial networks (GANs). We consider a situation when a labeled cadaveric surgery dataset is available while the task is instrument segmentation on an unlabeled live surgery da…
The CycleGAN framework allows for unsupervised image-to-image translation of unpaired data. In a scenario of surgical training on a physical surgical simulator, this method can be used to transform endoscopic images of phantoms into images which more closely resemble the intra-operative appearance of the same surgical target structure. This can be viewed as a novel augmented reality approach, which we coined Hyperrealism in previous work. In this use case, it is of paramount importance to display objects like needles, sutures or instruments consistent in both domains while altering the style t…
EndoLive: Real-Time Style Transfer for Endoscopic Endonasal Skull Base Surgical Video
University of Pittsburgh（匹兹堡大学）；University of Pittsburgh School of Computing and Information（匹兹堡大学计算与信息学院）；School of Computing and Information（计算与信息学院）
Politecnico di Milano（米兰理工大学）；Université de Strasbourg（斯特拉斯堡大学）；Hospital Papa Giovanni XXIII（教皇约翰二十三世医院）
Objective: Accurate visual classification of bladder tissue during Trans-Urethral Resection of Bladder Tumor (TURBT) procedures is essential to improve early cancer diagnosis and treatment. During TURBT interventions, White Light Imaging (WLI) and Narrow Band Imaging (NBI) techniques are used for lesion detection. Each imaging technique provides diverse visual information that allows clinicians to identify and classify cancerous lesions. Computer vision methods that use both imaging techniques could improve endoscopic diagnosis. We address the challenge of tissue classification when annotation…
Surgical tool segmentation in endoscopic images is an important problem: it is a crucial step towards full instrument pose estimation and it is used for integration of pre- and intra-operative images into the endoscopic view. While many recent approaches based on convolutional neural networks have shown great results, a key barrier to progress lies in the acquisition of a large number of manually-annotated images which is necessary for an algorithm to generalize and work well in diverse surgical scenarios. Unlike the surgical image data itself, annotations are difficult to acquire and may be o…
Eindhoven University of Technology（埃因霍温理工大学）；Philips Research Laboratories（飞利浦研究实验室）；Philips Healthcare（飞利浦医疗）
There has been considerable interest in the MR physics-based simulation of a database of virtual cardiac MR images for the development of deep-learning analysis networks. However, the employment of such a database is limited or shows suboptimal performance due to the realism gap, missing textures, and the simplified appearance of simulated images. In this work we 1) provide image simulation on virtual XCAT subjects with varying anatomies, and 2) propose sim2real translation network to improve image realism. Our usability experiments suggest that sim2real data exhibits a good potential to augme…
Intraoperative shape reconstruction of organs from endoscopic camera images is a complex yet indispensable technique for image-guided surgery. To address the uncertainty in reconstructing entire shapes from single-viewpoint occluded images, we propose a framework for generative virtual learning of shape reconstruction using image translation with common latent variables between simulated and real images. As it is difficult to prepare sufficient amount of data to learn the relationship between endoscopic images and organ shapes, self-supervised virtual learning is performed using simulated imag…
Queen Mary University of London（伦敦玛丽女王大学）；Karolinska University Hospital（卡罗林斯卡大学医院）
Histopathological cancer diagnosis is based on visual examination of stained tissue slides. Hematoxylin and eosin (H\&E) is a standard stain routinely employed worldwide. It is easy to acquire and cost effective, but cells and tissue components show low-contrast with varying tones of dark blue and pink, which makes difficult visual assessments, digital image analysis, and quantifications. These limitations can be overcome by IHC staining of target proteins of the tissue slide. IHC provides a selective, high-contrast imaging of cells and tissue components, but their use is largely limited by a …
Arizona State University（亚利桑那州立大学）；Mila – Quebec Artificial Intelligence Institute（魁北克人工智能研究所（Mila））；Mayo Clinic（梅奥诊所）
Generative adversarial networks (GANs) have ushered in a revolution in image-to-image translation. The development and proliferation of GANs raises an interesting question: can we train a GAN to remove an object, if present, from an image while otherwise preserving the image? Specifically, can a GAN "virtually heal" anyone by turning his medical image, with an unknown health status (diseased or healthy), into a healthy one, so that diseased regions could be revealed by subtracting those two images? Such a task requires a GAN to identify a minimal subset of target pixels for domain translation,…
Stony Brook University（石溪大学）；Memorial Sloan Kettering Cancer Center（纪念斯隆凯特琳癌症中心）
Haustral folds are colon wall protrusions implicated for high polyp miss rate during optical colonoscopy procedures. If segmented accurately, haustral folds can allow for better estimation of missed surface and can also serve as valuable landmarks for registering pre-treatment virtual (CT) and optical colonoscopies, to guide navigation towards the anomalies found in pre-treatment scans. We present a novel generative adversarial network, FoldIt, for feature-consistent image translation of optical colonoscopy videos to virtual colonoscopy renderings with haustral fold overlays. A new transitive …
Numerous deep learning based methods have been developed for nuclei segmentation for H&E images and have achieved close to human performance. However, direct application of such methods to another modality of images, such as Immunohistochemistry (IHC) images, may not achieve satisfactory performance. Thus, we developed a Generative Adversarial Network (GAN) based approach to translate an IHC image to an H&E image while preserving nuclei location and morphology and then apply pre-trained nuclei segmentation models to the virtual H&E image. We demonstrated that the proposed methods work better t…
Using real road testing to optimize autonomous driving algorithms is time-consuming and capital-intensive. To solve this problem, we propose a GAN-based model that is capable of generating high-quality images across different domains. We further leverage Contrastive Learning to train the model in a self-supervised way using image data acquired in the real world using real sensors and simulated images from 3D games. In this paper, we also apply an Attention Mechanism module to emphasize features that contain more information about the source domain according to their measurement of significance…
Building Trust in Virtual Immunohistochemistry: Automated Assessment of Image Quality
Kahlert School of Computing, University of Utah（犹他大学卡勒特计算学院）；Department of Internal Medicine, Division of Epidemiology, University of Utah（犹他大学内科学系流行病学部门）；Department of Pathology, University of Utah（犹他大学病理学系）；ARUP Laboratories（ARUP实验室）
Photorealistic image generation from simulated label maps are necessitated in several contexts, such as for medical training in virtual reality. With conventional deep learning methods, this task requires images that are paired with semantic annotations, which typically are unavailable. We introduce a contrastive learning framework for generating photorealistic images from simulated label maps, by learning from unpaired sets of both. Due to potentially large scene differences between real images and label maps, existing unpaired image translation methods lead to artifacts of scene modification…
Leveraging Adversarial Learning for Pathological Fidelity in Virtual Staining
INESC TEC, Faculdade de Engenharia, Universidade do Porto, Porto, Portugal（INESC TEC，工程学院， Porto 大学，Porto，葡萄牙）；The Netherlands Cancer Institute, Amsterdam, The Netherlands（荷兰癌症研究所，阿姆斯特丹，荷兰）；IMP Diagnostics, Porto, Portugal（IMP 诊断公司，Porto，葡萄牙）
Tokyo Institute of Technology（东京工业大学）；Nihon University School of Medicine（日本大学医学院）；Tsujinaka Hospital Kashiwanoha（柏之叶辻仲医院）
Gastric endoscopy is a standard clinical process that enables medical practitioners to diagnose various lesions inside a patient's stomach. If any lesion is found, it is very important to perceive the location of the lesion relative to the global view of the stomach. Our previous research showed that this could be addressed by reconstructing the whole stomach shape from chromoendoscopic images using a structure-from-motion (SfM) pipeline, in which indigo carmine (IC) blue dye sprayed images were used to increase feature matches for SfM by enhancing stomach surface's textures. However, spraying…
Nagoya University（名古屋大学）；Kyoto Second Red Cross Hospital（京都第二红十字医院）；Sapporo-Minami-Sanjo Hospital（札幌南三条医院）；Sapporo-Kosei General Hospital（札幌厚生综合医院）；Keiwakai Nishioka Hospital（惠和会西冈医院）；National Institute of Informatics（国立信息学研究所）
We propose a depth estimation method from a single-shot monocular endoscopic image using Lambertian surface translation by domain adaptation and depth estimation using multi-scale edge loss. We employ a two-step estimation process including Lambertian surface translation from unpaired data and depth estimation. The texture and specular reflection on the surface of an organ reduce the accuracy of depth estimations. We apply Lambertian surface translation to an endoscopic image to remove these texture and reflections. Then, we estimate the depth by using a fully convolutional network (FCN). Duri…
Virtual try-on is a promising application of computer graphics and human computer interaction that can have a profound real-world impact especially during this pandemic. Existing image-based works try to synthesize a try-on image from a single image of a target garment, but it inherently limits the ability to react to possible interactions. It is difficult to reproduce the change of wrinkles caused by pose and body size change, as well as pulling and stretching of the garment by hand. In this paper, we propose an alternative per garment capture and synthesis workflow to handle such rich intera…
Multi-domain image-to-image translation is a problem where the goal is to learn mappings among multiple domains. This problem is challenging in terms of scalability because it requires the learning of numerous mappings, the number of which increases proportional to the number of domains. However, generative adversarial networks (GANs) have emerged recently as a powerful framework for this problem. In particular, label-conditional extensions (e.g., StarGAN) have become a promising solution owing to their ability to address this problem using only a single unified model. Nonetheless, a limitatio…
Rochester Institute of Technology（罗切斯特理工学院）；University of Washington（华盛顿大学）；Seattle Children’s Hospital（西雅图儿童医院）
Abstract. Purpose: This paper presents a scheme for generating virtual intraoperative CT scans in order to improve surgical completeness in Endoscopic Sinus Surgeries (ESS). Approach: The work presents three methods, the tip motion-based, the tip trajectory-based, and the instrument based, along with non-parametric smoothing and Gaussian Process Regression, for virtual intraoperative CT generation. Results: The proposed methods studied and compared on ESS performed on cadavers. Surgical results show all three methods improve the Dice Similarity Coefficients > 86%, with F-score > 92% and precis…
Whole-Body Image-to-Image Translation for a Virtual Scanner in a Healthcare Digital Twin
Department of Computing Science, Umeå University（计算科学系，乌梅大学）；Department of Diagnostics and Intervention, Biomedical Engineering and Radiation Physics, Umeå University（诊断与介入系，生物医学工程与放射物理，乌梅大学）
Seoul National University of Science and Technology（首尔科学技术大学）
In this paper, we propose a dense depth estimation pipeline for multiview 360° images. The proposed pipeline leverages a spherical camera model that compensates for radial distortion in 360° images. The key contribution of this paper is the extension of a spherical camera model to multiview by introducing a translation scaling scheme. Moreover, we propose an effective dense depth estimation method by setting virtual depth and minimizing photonic reprojection error. We validate the performance of the proposed pipeline using the images of natural scenes as well as the synthesized dataset for qua…
IIT Hyderabad（印度理工学院海得拉巴分校）；Media and Data Science Research Lab, Adobe（奥多比媒体与数据科学研究实验室）；Stanford University（斯坦福大学）；IIIT Hyderbad（印度国际信息技术学院海得拉巴分校）
Image-based virtual try-on for fashion has gained considerable attention recently. The task requires trying on a clothing item on a target model image. An efficient framework for this is composed of two stages: (1) warping (transforming) the try-on cloth to align with the pose and shape of the target model, and (2) a texture transfer module to seamlessly integrate the warped try-on cloth onto the target model image. Existing methods suffer from artifacts and distortions in their try-on output. In this work, we present SieveNet, a framework for robust image-based virtual try-on. Firstly, we int…
Fourier ptychographic microscopy (FPM) is a computational approach geared towards creating high-resolution and large field-of-view images without mechanical scanning. To acquire color images of histology slides, it often requires sequential acquisitions with red, green, and blue illuminations. The color reconstructions often suffer from coherent artifacts that are not presented in regular incoherent microscopy images. As a result, it remains a challenge to employ FPM for digital pathology applications, where resolution and color accuracy are of critical importance. Here we report a deep learni…
