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arXiv 2110.00166cond-mat.softphysics.bio-ph
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活性微管-肌动蛋白复合物中的伸展到收缩转变产生具有可编程寿命的层状asters

Extensile to contractile transition in active microtubule-actin composites generates layered asters with programmable lifetimes

John Berezney, Bruce L. Goode, Seth Fraden, Zvonimir Dogic

摘要:

我们研究了一个重组的复合系统,由一个主动的微管网络与一个被动的网络纠缠的F-肌动蛋白丝交叉。增加的粘弹性的F-肌动蛋白网络控制的紧急动态,诱导从顺从性的流动到批量收缩的过渡。在中间的F-肌动蛋白浓度,其中的主动应力改变其对称性从各向异性伸展到各向同性收缩,该复合材料分离成层状asters共存的背景湍流流体。收缩的洋葱状紫苑有一个径向延伸的微管丰富的皮层,它包含微管和F-肌动蛋白的交替层。自我调节的层状组织在星合并事件中幸存下来,这让人想起液滴聚结,并表明存在有效的表面张力。最后,层状星状结构是亚稳态结构。它们的寿命从几分钟到几小时不等,编码在复合材料的材料特性中。总之,这些结果挑战了当前的活性物质模型。他们表明,自组织的动态状态和模式,这是令人回味的细胞骨架中观察到的,不需要精确的生化调节,但可以出现由于积极驱动的丝状材料的纯机械相互作用。

英文摘要:

We study a reconstituted composite system consisting of an active microtubule network interdigitated with a passive network of entangled F-actin filaments. Increasing viscoelasticity of the F-actin network controls the emergent dynamics, inducing a transition from turbulent-like flows to bulk contractions. At intermediate F-actin concentrations, where the active stresses change their symmetry from anisotropic extensile to isotropic contracting, the composite separates into layered asters that coexist with the background turbulent fluid. Contracted onion-like asters have a radially extending microtubule-rich cortex that envelops alternating layers of microtubules and F-actin. The self-regulating layered organization survives aster merging events, which are reminiscent of droplet coalescence, and suggest the presence of effective surface tension. Finally, the layered asters are metastable structures. Their lifetime, which ranges from minutes to hours, is encoded in the material properties of the composite. Taken together, these results challenge the current models of active matter. They demonstrate that the self-organized dynamical states and patterns, which are evocative of those observed in the cytoskeleton, do not require precise biochemical regulation but can arise due to purely mechanical interactions of actively driven filamentous materials.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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