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arXiv 2109.06559stat.MEstat.OT
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网络荟萃分析中基于贝叶斯模型的离群点检测

Bayesian model-based outlier detection in network meta-analysis

Silvia Metelli, Dimitris Mavridis, Perrine Créquit, Anna Chaimani

摘要:

在网络荟萃分析中,一些收集的研究可能与其他研究有明显的偏差,例如具有非常不寻常的效应量。这些偏离研究相对于网络的其余部分可被视为离群研究,并可能对汇总结果产生影响。因此,在不作进一步调查的情况下综合这些研究可能是不适当的。在本文中,我们提出了两种贝叶斯方法来检测网络荟萃分析中的离群值:(a)均值漂移离群值模型和(b)从ad-hoc差异度量构建的后验预测p值。前一种方法使用贝叶斯因子对每个研究进行正式测试,而后者为网络中的每个研究提供了一个离群度得分,这允许在数字上量化与离群值相关的不确定性。此外,我们提出了一个简单的方法,基于信息先验作为网络荟萃分析模型的一部分,以降低检测到的离群值的权重。我们进行了广泛的模拟,以评估所提出的方法的有效性,同时将其与一些替代的,可用的离群值诊断工具进行比较。两个真正的干预网络,然后用来证明我们的方法在实践中。

英文摘要:

In a network meta-analysis, some of the collected studies may deviate markedly from the others, for example having very unusual effect sizes. These deviating studies can be regarded as outlying with respect to the rest of the network and can be influential on the pooled results. Thus, it could be inappropriate to synthesize those studies without further investigation. In this paper, we propose two Bayesian methods to detect outliers in a network meta-analysis via: (a) a mean-shifted outlier model and (b), posterior predictive p-values constructed from ad-hoc discrepancy measures. The former method uses Bayes factors to formally test each study against outliers while the latter provides a score of outlyingness for each study in the network, which allows to numerically quantify the uncertainty associated with being outlier. Furthermore, we present a simple method based on informative priors as part of the network meta-analysis model to down-weight the detected outliers. We conduct extensive simulations to evaluate the effectiveness of the proposed methodology while comparing it to some alternative, available outlier diagnostic tools. Two real networks of interventions are then used to demonstrate our methods in practice.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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