细胞消除的力学基础与拓扑路径
Mechanical basis and topological routes to cell elimination
AI总结：
利用三维相场模型研究细胞挤出，揭示黏附力调控下挤出事件与向列序、六角序缺陷的关联，并阐明其作为局部应力释放机制的作用。
摘要：
细胞层通过挤出过程清除不需要的细胞，这一过程决定了健康组织与缺陷组织行为的差异。尽管已鉴定出若干生化通路，但细胞挤出背后的力学基础，包括所涉及的力，在很大程度上仍未得到探索。利用三维细胞层的相场模型，我们研究了平面单层中细胞挤出与细胞-细胞及细胞-基底相互作用的耦合关系。通过独立调节细胞-细胞与细胞-基底黏附力，我们发现挤出事件可与细胞排列相关的向列序和六角序缺陷明确关联。具体而言，我们表明，通过增大相对细胞-细胞黏附力，细胞单层可以在挤出细胞时从倾向于五重六角向错转变为倾向于半整数向列缺陷。我们通过获取三维力学应力场来统一这些发现，表明挤出事件充当了一种缓解局部应力集中的机制。
英文摘要：
Cell layers eliminate unwanted cells through the extrusion process, which underlines healthy versus flawed tissue behaviors. Although several biochemical pathways have been identified, the underlying mechanical basis including the forces involved in cellular extrusion remain largely unexplored. Utilizing a phase-field model of a three-dimensional cell layer, we study the interplay of cell extrusion with cell-cell and cell-substrate interactions, in a flat monolayer. Independent tuning of cell-cell versus cell-substrate adhesion forces reveals that extrusion events can be distinctly linked to defects in nematic and hexatic orders associated with cellular arrangements. Specifically, we show that by increasing relative cell-cell adhesion forces the cell monolayer can switch between the collective tendency towards five-fold, hexatic, disclinations relative to half-integer, nematic, defects for extruding a cell. We unify our findings by accessing three-dimensional mechanical stress fields to show that an extrusion event acts as a mechanism to relieve localized stress concentration.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
