The Reverse Transcription Polymerase Chain Reaction (RTPCR)} test is the silver bullet diagnostic test to discern COVID infection. Rapid antigen detection is a screening test to identify COVID positive patients in little as 15 minutes, but has a lower sensitivity than the PCR tests. Besides having multiple standardized test kits, many people are getting infected and either recovering or dying even before the test due to the shortage and cost of kits, lack of indispensable specialists and labs, time-consuming result compared to bulk population especially in developing and underdeveloped countries. Intrigued by the parametric deviations in immunological and hematological profile of a COVID patient, this research work leveraged the concept of COVID-19 detection by proposing a risk-free and highly accurate Stacked Ensemble Machine Learning model to identify a COVID patient from communally available-widespread-cheap routine blood tests which gives a promising accuracy, precision, recall and F1-score of 100%. Analysis from R-curve also shows the preciseness of the risk-free model to be implemented. The proposed method has the potential for large scale ubiquitous low-cost screening application. This can add an extra layer of protection in keeping the number of infected cases to a minimum and control the pandemic by identifying asymptomatic or pre-symptomatic people early.
Bloodstock shortages and its uncertain demand has become a major problem for all countries worldwide. Therefore, this study aims to provide solution to the issues of blood distribution during the Covid-19 Pandemic at Bengkulu, Indonesia. The Backpropagation algorithm was used to improve the possibility of discovering available and potential donors. Furthermore, the distances, age, and length of donation were measured to obtain the right person to donate blood when it needed. The Backpropagation uses three input layers to classify eligible donors, namely age, body, weight, and bias. In addition…
COVID-19 diagnosis by routine blood tests using machine learning
Smart Blood Analytics Swiss SA（智能血液分析瑞士公司）；Faculty of Computer and Information Science, University of Ljubljana（卢布尔雅那大学计算机与信息科学学院）；Faculty of Chemistry and Chemical Technology, University of Ljubljana（卢布尔雅那大学化学与化学技术学院）；University Medical Centre Ljubljana（卢布尔雅那大学医学中心）
Iowa State University（爱荷华州立大学）；Union Hospital, Tongji Medical College, Huazhong University of Science and Technology（华中科技大学同济医学院附属 Union 医院）；Jiangsu Provincial Center for Disease Control and Prevention（江苏省疾病预防控制中心）；Public Health Research Institute of Jiangsu Province（江苏省公共卫生研究院）；Kunshan People's Hospital Affiliated To Jiangsu University（江苏大学附属昆山人民医院）；University of British Columbia（不列颠哥伦比亚大学）；University of North Carolina at Charlotte（北卡罗来纳大学夏洛特分校）；College of Health and Human Services, University of North Carolina at Charlotte（北卡罗来纳大学夏洛特分校健康与人类服务学院）；School of Data Science, College of Health and Human Services, University of North Carolina at Charlotte（北卡罗来纳大学夏洛特分校数据科学学院）
The COVID-19 is sweeping the world with deadly consequences. Its contagious nature and clinical similarity to other pneumonias make separating subjects contracted with COVID-19 and non-COVID-19 viral pneumonia a priority and a challenge. However, COVID-19 testing has been greatly limited by the availability and cost of existing methods, even in developed countries like the US. Intrigued by the wide availability of routine blood tests, we propose to leverage them for COVID-19 testing using the power of machine learning. Two proven-robust machine learning model families, random forests (RFs) and…
Bangabandhu Sheikh Mujibur Rahman Science & Technology University（班加班杜谢赫穆吉布·拉赫曼科技大学）；University of Rajshahi（拉杰沙希大学）；University of Technology Sydney（悉尼科技大学）；The University of Sydney（悉尼大学）；Jatiya Kabi Kazi Nazrul Islam University（贾蒂亚·卡比·卡齐·纳兹鲁尔·伊斯兰大学）；Imam Mohammad Ibn Saud Islamic University（伊玛目穆罕默德·伊本·沙特伊斯兰大学）；University of New South Wales（新南威尔士大学）；Deakin University（迪肯大学）；The Garvan Institute of Medical Research（加尔文医学研究所）
Introduction: For COVID-19 patients accurate prediction of disease severity and mortality risk would greatly improve care delivery and resource allocation. There are many patient-related factors, such as pre-existing comorbidities that affect disease severity. Since rapid automated profiling of peripheral blood samples is widely available, we investigated how such data from the peripheral blood of COVID-19 patients might be used to predict clinical outcomes. Methods: We thus investigated such clinical datasets from COVID-19 patients with known outcomes by combining statistical comparison and c…
Erzincan Binali Yıldırım University（埃尔津詹比纳利耶尔德勒姆大学）；Petrozavodsk State University（彼得罗扎沃茨克国立大学）
Since February 2020, the world has been engaged in an intense struggle with the COVID-19 dis-ease, and health systems have come under tragic pressure as the disease turned into a pandemic. The aim of this study is to obtain the most effective routine blood values (RBV) in the diagnosis and prognosis of COVID-19 using a backward feature elimination algorithm for the LogNNet reservoir neural network. The first dataset in the study consists of a total of 5296 patients with the same number of negative and positive COVID-19 tests. The LogNNet-model achieved the accuracy rate of 99.5% in the diagnos…
University of California Irvine（加州大学欧文分校）；University of Turku（图尔库大学）；University of Miami（迈阿密大学）
The world has been affected by COVID-19 coronavirus. At the time of this study, the number of infected people in the United States is the highest globally (7.9 million infections). Within the infected population, patients diagnosed with acute respiratory distress syndrome (ARDS) are in more life-threatening circumstances, resulting in severe respiratory system failure. Various studies have investigated the infections to COVID-19 and ARDS by monitoring laboratory metrics and symptoms. Unfortunately, these methods are merely limited to clinical settings, and symptom-based methods are shown to be…
Petrozavodsk State University（彼得罗扎沃茨克国立大学）；Erzincan Binali Yıldırım University（埃尔津詹·比纳利·耶尔德勒姆大学）
Healthcare digitalization requires effective applications of human sensors, when various parameters of the human body are instantly monitored in everyday life due to the Internet of Things (IoT). In particular, machine learning (ML) sensors for the prompt diagnosis of COVID-19 are an important option for IoT application in healthcare and ambient assisted living (AAL). Determining a COVID-19 infected status with various diagnostic tests and imaging results is costly and time-consuming. This study provides a fast, reliable and cost-effective alternative tool for the diagnosis of COVID-19 based o…
Erzincan Binali Yıldırım University（埃尔津詹比纳利·耶尔德勒姆大学）；Petrozavodsk State University（彼得罗扎沃茨克国立大学）
Early evaluation of patients who require special care and who have high death-expectancy in COVID-19, and the effective determination of relevant biomarkers on large sample-groups are important to reduce mortality. This study aimed to reveal the routine blood-value predictors of COVID-19 mortality and to determine the lethal-risk levels of these predictors during the disease process. The dataset of the study consists of 38 routine blood-values of 2597 patients who died (n = 233) and those who recovered (n = 2364) from COVID-19 in August-December, 2021. In this study, the histogram-based gradie…
University of Michigan（密歇根大学）；Fudan University（复旦大学）；Shenzhen University（深圳大学）
Amid the ongoing COVID-19 pandemic, whether COVID-19 patients with high risks can be recovered or not depends, to a large extent, on how early they will be treated appropriately before irreversible consequences are caused to the patients by the virus. In this research, we reported an explainable, intuitive, and accurate machine learning model based on logistic regression to predict the fatality rate of COVID-19 patients using only three important blood biomarkers, including lactic dehydrogenase, lymphocyte (%) and high-sensitivity C-reactive protein, and their interactions. We found that when …
University of Toronto（多伦多大学）；Khulna University of Engineering and Technology（库尔纳工程技术大学）；Islamic University of Technology（伊斯兰技术大学）；Bangladesh University of Business and Technology（孟加拉国商业与技术大学）
To contain the spread of the virus and stop the overcrowding of hospitalized patients, the coronavirus pandemic crippled healthcare facilities, mandating lockdowns and promoting remote work. As a result, telehealth has become increasingly popular for offering low-risk care to patients. However, the difficulty of preventing the next potential waves of infection has increased by constant virus mutation into new forms and a general lack of test kits, particularly in developing nations. In this research, a unique cloud-based application for the early identification of individuals who may have COVI…
CVSSP, University of Surrey（萨里大学视觉、语音与信号处理中心）；Department of Engineering Science, University of Oxford（牛津大学工程科学系）；UK Dementia Research Institute Care Research and Technology Centre, Imperial College London（伦敦帝国理工学院英国痴呆症研究所护理研究与技术中心）；University of Surrey（萨里大学）；Queen Mary University of London（伦敦玛丽女王大学）；Oxford-Suzhou Centre for Advanced Research（牛津大学苏州高等研究院）；John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust（牛津大学医院NHS基金会信托约翰·拉德克利夫医院）；RDM Division of Cardiovascular Medicine, University of Oxford（牛津大学拉德克利夫医学系心血管医学部）
Early detection of COVID-19 is an ongoing area of research that can help with triage, monitoring and general health assessment of potential patients and may reduce operational strain on hospitals that cope with the coronavirus pandemic. Different machine learning techniques have been used in the literature to detect coronavirus using routine clinical data (blood tests, and vital signs). Data breaches and information leakage when using these models can bring reputational damage and cause legal issues for hospitals. In spite of this, protecting healthcare models against leakage of potentially se…
F. Hoffmann-La Roche Ltd（罗氏制药有限公司）；ETH Zurich（苏黎世联邦理工学院）；Max Planck Institute of Intelligent Systems（马克斯·普朗克智能系统研究所）
Coronavirus Disease 2019 (COVID-19) is a rapidly emerging respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to the rapid human-to-human transmission of SARS-CoV-2, many healthcare systems are at risk of exceeding their healthcare capacities, in particular in terms of SARS-CoV-2 tests, hospital and intensive care unit (ICU) beds and mechanical ventilators. Predictive algorithms could potentially ease the strain on healthcare systems by identifying those who are most likely to receive a positive SARS-CoV-2 test, be hospitalised or admitted to the…
When we face patients arriving to a hospital suffering from the effects of some illness, one of the main problems we can encounter is evaluating whether or not said patients are going to require intensive care in the near future. This intensive care requires allotting valuable and scarce resources, and knowing beforehand the severity of a patients illness can improve both its treatment and the organization of resources. We illustrate this issue in a dataset consistent of Spanish COVID-19 patients from the sixth epidemic wave where we label patients as critical when they either had to enter the…
Rutgers University（罗格斯大学）；Rutgers Robert Wood Johnson Medical School（罗格斯罗伯特伍德约翰逊医学院）
The COVID-19 corona virus has claimed 4.1 million lives, as of July 24, 2021. A variety of machine learning models have been applied to related data to predict important factors such as the severity of the disease, infection rate and discover important prognostic factors. Often the usefulness of the findings from the use of these techniques is reduced due to lack of method interpretability. Some recent progress made on the interpretability of machine learning models has the potential to unravel more insights while using conventional machine learning models. In this work, we analyze COVID-19 bl…
Indian Institute of Technology, Delhi（印度理工学院德里分校）；AFMC, Pune（武装部队医学院，浦那）；CMC Ludhiana（卢迪亚纳基督教医学院）
As the second wave in India mitigates, COVID-19 has now infected about 29 million patients countrywide, leading to more than 350 thousand people dead. As the infections surged, the strain on the medical infrastructure in the country became apparent. While the country vaccinates its population, opening up the economy may lead to an increase in infection rates. In this scenario, it is essential to effectively utilize the limited hospital resources by an informed patient triaging system based on clinical parameters. Here, we present two interpretable machine learning models predicting the clinica…
Qatar University（卡塔尔大学）；University of Dhaka（达卡大学）；College of Medicine, QU Health, Qatar University（卡塔尔大学QU Health医学院）；Universiti Kebangsaan Malaysia（马来西亚国民大学）
COVID-19 pandemic has created an extreme pressure on the global healthcare services. Fast, reliable and early clinical assessment of the severity of the disease can help in allocating and prioritizing resources to reduce mortality. In order to study the important blood biomarkers for predicting disease mortality, a retrospective study was conducted on 375 COVID-19 positive patients admitted to Tongji Hospital (China) from January 10 to February 18, 2020. Demographic and clinical characteristics, and patient outcomes were investigated using machine learning tools to identify key biomarkers to p…
University of Waterloo（滑铁卢大学）；DarwinAI Corp.（达尔文人工智能公司）
The coronavirus disease 2019 (COVID-19) pandemic continues to have a tremendous impact on patients and healthcare systems around the world. In the fight against this novel disease, there is a pressing need for rapid and effective screening tools to identify patients infected with COVID-19, and to this end CT imaging has been proposed as one of the key screening methods which may be used as a complement to RT-PCR testing, particularly in situations where patients undergo routine CT scans for non-COVID-19 related reasons, patients with worsening respiratory status or developing complications tha…
The novel coronavirus disease (COVID-19) has crushed daily routines and is still rampaging through the world. Existing solution for nonpharmaceutical interventions usually needs to timely and precisely select a subset of residential urban areas for containment or even quarantine, where the spatial distribution of confirmed cases has been considered as a key criterion for the subset selection. While such containment measure has successfully stopped or slowed down the spread of COVID-19 in some countries, it is criticized for being inefficient or ineffective, as the statistics of confirmed cases…
Darmstadt University of Technology（达姆施塔特工业大学）；Uniklinik Frankfurt（法兰克福大学医院）
Automatic segmentation of ground glass opacities and consolidations in chest computer tomography (CT) scans can potentially ease the burden of radiologists during times of high resource utilisation. However, deep learning models are not trusted in the clinical routine due to failing silently on out-of-distribution (OOD) data. We propose a lightweight OOD detection method that leverages the Mahalanobis distance in the feature space and seamlessly integrates into state-of-the-art segmentation pipelines. The simple approach can even augment pre-trained models with clinically relevant uncertainty …
University of Waterloo（滑铁卢大学）；Waterloo Artificial Intelligence Institute（滑铁卢人工智能研究所）；DarwinAI Corp.（DarwinAI公司）；McMaster University（麦克马斯特大学）；Thunder Bay Regional Health Sciences Centre（桑德贝地区健康科学中心）；Northern Ontario School of Medicine（北安大略医学院）
As the COVID-19 pandemic continues to devastate globally, the use of chest X-ray (CXR) imaging as a complimentary screening strategy to RT-PCR testing continues to grow given its routine clinical use for respiratory complaint. As part of the COVID-Net open source initiative, we introduce COVID-Net CXR-2, an enhanced deep convolutional neural network design for COVID-19 detection from CXR images built using a greater quantity and diversity of patients than the original COVID-Net. To facilitate this, we also introduce a new benchmark dataset composed of 19,203 CXR images from a multinational coh…
Universal Laboratory Model: prognosis of abnormal clinical outcomes based on routine tests
Department of medicinal chemistry Moscow State University（药物化学系莫斯科国立大学）；Department of computer science Samara National Research University（计算机科学系萨马拉国立研究大学）
Technical University of Munich（慕尼黑工业大学）；Johns Hopkins University（约翰斯·霍普金斯大学）
During the first wave of COVID-19, hospitals were overwhelmed with the high number of admitted patients. An accurate prediction of the most likely individual disease progression can improve the planning of limited resources and finding the optimal treatment for patients. However, when dealing with a newly emerging disease such as COVID-19, the impact of patient- and disease-specific factors (e.g. body weight or known co-morbidities) on the immediate course of disease is by and large unknown. In the case of COVID-19, the need for intensive care unit (ICU) admission of pneumonia patients is ofte…
CovidLLM: A Robust Large Language Model with Missing Value Adaptation and Multi-Objective Learning Strategy for Predicting Disease Severity and Clinical Outcomes in COVID-19 Patients
School of Mathematics and Statistics, Xiamen University of Technology（厦门理工学院数学与统计学院）；School of Computer and Information Engineering, Xiamen University of Technology（厦门理工学院计算机与信息工程学院）；Tongji Medical College, Huazhong University of Science and Technology（华中科技大学同济医学院）
National Heart and Lung Institute, Imperial College London（帝国理工学院国家心肺研究所）；Royal Brompton Hospital（皇家布朗普顿医院）；Shenzhen Second People’s Hospital（深圳市第二人民医院）；TECNALIA（泰克纳利亚研究中心）；University of the Basque Country（巴斯克大学）
The upheaval brought by the arrival of the COVID-19 pandemic has continued to bring fresh challenges over the past two years. During this COVID-19 pandemic, there has been a need for rapid identification of infected patients and specific delineation of infection areas in computed tomography (CT) images. Although deep supervised learning methods have been established quickly, the scarcity of both image-level and pixel-level labels as well as the lack of explainable transparency still hinder the applicability of AI. Can we identify infected patients and delineate the infections with extreme mini…
During the coronavirus disease 2019 (COVID-19) pandemic, rapid and accurate triage of patients at the emergency department is critical to inform decision-making. We propose a data-driven approach for automatic prediction of deterioration risk using a deep neural network that learns from chest X-ray images and a gradient boosting model that learns from routine clinical variables. Our AI prognosis system, trained using data from 3,661 patients, achieves an area under the receiver operating characteristic curve (AUC) of 0.786 (95% CI: 0.745-0.830) when predicting deterioration within 96 hours. Th…
Qatar University（卡塔尔大学）；North South University（北南大学）；University of South Carolina（南卡罗来纳大学）；Hamad General Hospital（哈马德综合医院）；AFG College with the University of Aberdeen（阿伯丁大学AFG学院）
Fast and accurate detection of the disease can significantly help in reducing the strain on the healthcare facility of any country to reduce the mortality during any pandemic. The goal of this work is to create a multimodal system using a novel machine learning framework that uses both Chest X-ray (CXR) images and clinical data to predict severity in COVID-19 patients. In addition, the study presents a nomogram-based scoring technique for predicting the likelihood of death in high-risk patients. This study uses 25 biomarkers and CXR images in predicting the risk in 930 COVID-19 patients admitt…
Biomedical Imaging Research Institute, Cedars-Sinai Medical Center（西达赛奈医学中心生物医学成像研究所）；Cedars-Sinai Medical Center（西达赛奈医学中心）；Semmelweis University（塞梅尔维斯大学）；Azienda Ospedaliero-Universitaria di Parma（帕尔马大学医院）；Monash Health（莫纳什医疗中心）；Centro Cardiologico Monzino IRCCS, University of Milan（米兰大学蒙齐诺心脏中心IRCCS）；Showa University School of Medicine（昭和大学医学院）
Quantitative lung measures derived from computed tomography (CT) have been demonstrated to improve prognostication in coronavirus disease (COVID-19) patients, but are not part of the clinical routine since required manual segmentation of lung lesions is prohibitively time-consuming. We propose a new fully automated deep learning framework for rapid quantification and differentiation between lung lesions in COVID-19 pneumonia from both contrast and non-contrast CT images using convolutional Long Short-Term Memory (ConvLSTM) networks. Utilizing the expert annotations, model training was performe…
Contrasting Deep Learning Models for Direct Respiratory Insufficiency Detection Versus Blood Oxygen Saturation Estimation
IME - University of São Paulo（圣保罗大学IME学院）；Federal Technological University of Parana（巴拉那联邦技术大学）；IBILCE - São Paulo State University（圣保罗州立大学IBILCE学院）；São Paulo State University（圣保罗州立大学）；FMUSP - University of São Paulo（圣保罗大学FMUSP学院）；FFLCH - University of São Paulo（圣保罗大学FFLCH学院）
