Coronavirus Disease 2019 (COVID-19) is a rapidly emerging respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to the rapid human-to-human transmission of SARS-CoV-2, many healthcare systems are at risk of exceeding their healthcare capacities, in particular in terms of SARS-CoV-2 tests, hospital and intensive care unit (ICU) beds and mechanical ventilators. Predictive algorithms could potentially ease the strain on healthcare systems by identifying those who are most likely to receive a positive SARS-CoV-2 test, be hospitalised or admitted to the ICU. Here, we study clinical predictive models that estimate, using machine learning and based on routinely collected clinical data, which patients are likely to receive a positive SARS-CoV-2 test, require hospitalisation or intensive care. To evaluate the predictive performance of our models, we perform a retrospective evaluation on clinical and blood analysis data from a cohort of 5644 patients. Our experimental results indicate that our predictive models identify (i) patients that test positive for SARS-CoV-2 a priori at a sensitivity of 75% (95% CI: 67%, 81%) and a specificity of 49% (95% CI: 46%, 51%), (ii) SARS-CoV-2 positive patients that require hospitalisation with 0.92 AUC (95% CI: 0.81, 0.98), and (iii) SARS-CoV-2 positive patients that require critical care with 0.98 AUC (95% CI: 0.95, 1.00). In addition, we determine which clinical features are predictive to what degree for each of the aforementioned clinical tasks. Our results indicate that predictive models trained on routinely collected clinical data could be used to predict clinical pathways for COVID-19, and therefore help inform care and prioritise resources.
Carnegie Mellon University（卡内基梅隆大学）；Highmark Health（高马克健康）；Allegheny Health Network（阿勒格尼健康网络）
With COVID-19 now pervasive, identification of high-risk individuals is crucial. Using data from a major healthcare provider in Southwestern Pennsylvania, we develop survival models predicting severe COVID-19 progression. In this endeavor, we face a tradeoff between more accurate models relying on many features and less accurate models relying on a few features aligned with clinician intuition. Complicating matters, many EHR features tend to be under-coded, degrading the accuracy of smaller models. In this study, we develop two sets of high-performance risk scores: (i) an unconstrained model b…
DarwinAI Corp.（DarwinAI公司）；University of Waterloo（滑铁卢大学）；Waterloo Artificial Intelligence Institute（滑铁卢人工智能研究所）
The COVID-19 pandemic continues to have a devastating global impact, and has placed a tremendous burden on struggling healthcare systems around the world. Given the limited resources, accurate patient triaging and care planning is critical in the fight against COVID-19, and one crucial task within care planning is determining if a patient should be admitted to a hospital's intensive care unit (ICU). Motivated by the need for transparent and trustworthy ICU admission clinical decision support, we introduce COVID-Net Clinical ICU, a neural network for ICU admission prediction based on patient cl…
Coronavirus disease 2019 (COVID-19) is a global pandemic. Although much has been learned about the novel coronavirus since its emergence, there are many open questions related to tracking its spread, describing symptomology, predicting the severity of infection, and forecasting healthcare utilization. Free-text clinical notes contain critical information for resolving these questions. Data-driven, automatic information extraction models are needed to use this text-encoded information in large-scale studies. This work presents a new clinical corpus, referred to as the COVID-19 Annotated Clinica…
COVID-19 clinical trial design is a critical task in developing therapeutics for the prevention and treatment of COVID-19. In this study, we apply a deep learning approach to extract eligibility criteria variables from COVID-19 trials to enable quantitative analysis of trial design and optimization. Specifically, we train attention-based bidirectional Long Short-Term Memory (Att-BiLSTM) models and use the optimal model to extract entities (i.e., variables) from the eligibility criteria of COVID-19 trials. We compare the performance of Att-BiLSTM with traditional ontology-based method. The resu…
COVID-Net Biochem: An Explainability-driven Framework to Building Machine Learning Models for Predicting Survival and Kidney Injury of COVID-19 Patients from Clinical and Biochemistry Data
Stony Brook University（石溪大学）；University of Waterloo（滑铁卢大学）；Waterloo Artificial Intelligence Institute（滑铁卢人工智能研究所）；DarwinAI Corp.（达尔文人工智能公司）；McGill University（麦吉尔大学）
Virufy AI Research Group（Virufy AI研究组）；University of Alexandria（亚历山大大学）；Stanford University（斯坦福大学）；Duke University（杜克大学）
Rapid and affordable methods of testing for COVID-19 infections are essential to reduce infection rates and prevent medical facilities from becoming overwhelmed. Current approaches of detecting COVID-19 require in-person testing with expensive kits that are not always easily accessible. This study demonstrates that crowdsourced cough audio samples recorded and acquired on smartphones from around the world can be used to develop an AI-based method that accurately predicts COVID-19 infection with an ROC-AUC of 77.1% (75.2%-78.3%). Furthermore, we show that our method is able to generalize to cro…
We propose the novel use of a generative adversarial network (GAN) (i) to make predictions in time (PredGAN) and (ii) to assimilate measurements (DA-PredGAN). In the latter case, we take advantage of the natural adjoint-like properties of generative models and the ability to simulate forwards and backwards in time. GANs have received much attention recently, after achieving excellent results for their generation of realistic-looking images. We wish to explore how this property translates to new applications in computational modelling and to exploit the adjoint-like properties for efficient dat…
University of Wisconsin（威斯康星大学）；Henry Ford Health（亨利福特医疗集团）
Purpose: To answer the long-standing question of whether a model trained from a single clinical site can be generalized to external sites. Materials and Methods: 17,537 chest x-ray radiographs (CXRs) from 3,264 COVID-19-positive patients and 4,802 COVID-19-negative patients were collected from a single site for AI model development. The generalizability of the trained model was retrospectively evaluated using four different real-world clinical datasets with a total of 26,633 CXRs from 15,097 patients (3,277 COVID-19-positive patients). The area under the receiver operating characteristic curve…
Understanding the temporal dynamics of COVID-19 patient phenotypes is necessary to derive fine-grained resolution of pathophysiology. Here we use state-of-the-art deep neural networks over an institution-wide machine intelligence platform for the augmented curation of 15.8 million clinical notes from 30,494 patients subjected to COVID-19 PCR diagnostic testing. By contrasting the Electronic Health Record (EHR)-derived clinical phenotypes of COVID-19-positive (COVIDpos, n=635) versus COVID-19-negative (COVIDneg, n=29,859) patients over each day of the week preceding the PCR testing date, we ide…
NASA Jet Propulsion Lab（NASA喷气推进实验室）；UT Dallas（德克萨斯大学达拉斯分校）；Princeton University（普林斯顿大学）
As multiple adverse events in 2021 illustrated, virtually all aspects of our societal functioning -- from water and food security to energy supply to healthcare -- more than ever depend on the dynamics of environmental factors. Nevertheless, the social dimensions of weather and climate are noticeably less explored by the machine learning community, largely, due to the lack of reliable and easy access to use data. Here we present a unique not yet broadly available NASA's satellite dataset on aerosol optical depth (AOD), temperature and relative humidity and discuss the utility of these new data…
In this chapter, we provide a brief overview of applying machine learning techniques for clinical prediction tasks. We begin with a quick introduction to the concepts of machine learning and outline some of the most common machine learning algorithms. Next, we demonstrate how to apply the algorithms with appropriate toolkits to conduct machine learning experiments for clinical prediction tasks. The objectives of this chapter are to (1) understand the basics of machine learning techniques and the reasons behind why they are useful for solving clinical prediction problems, (2) understand the int…
Scuola Normale Superiore（比萨高等师范学校）；Institute of Clinical Physiology, C.N.R（意大利国家研究委员会临床生理学研究所）；University of Pisa（比萨大学）
We present a workflow for clinical data analysis that relies on Bayesian Structure Learning (BSL), an unsupervised learning approach, robust to noise and biases, that allows to incorporate prior medical knowledge into the learning process and that provides explainable results in the form of a graph showing the causal connections among the analyzed features. The workflow consists in a multi-step approach that goes from identifying the main causes of patient's outcome through BSL, to the realization of a tool suitable for clinical practice, based on a Binary Decision Tree (BDT), to recognize pat…
Because of the rapid spread of COVID-19 to almost every part of the globe, huge volumes of data and case studies have been made available, providing researchers with a unique opportunity to find trends and make discoveries like never before, by leveraging such big data. This data is of many different varieties, and can be of different levels of veracity e.g., precise, imprecise, uncertain, and missing, making it challenging to extract important information from such data. Yet, efficient analyses of this continuously growing and evolving COVID-19 data is crucial to inform -- often in real-time …
We provide a predictive analysis of the spread of COVID-19, also known as SARS-CoV-2, using the dataset made publicly available online by the Johns Hopkins University. Our main objective is to provide predictions of the number of infected people for different countries in the next 14 days. The predictive analysis is done using time-series data transformed on a logarithmic scale. We use two well-known methods for prediction: polynomial regression and neural network. As the number of training data for each country is limited, we use a single-layer neural network called the extreme learning machi…
Caltech（加州理工学院）；Walter Burke Institute for Theoretical Physics（沃尔特·伯克理论物理研究所）
Predictive models with a focus on different spatial-temporal scales benefit governments and healthcare systems to combat the COVID-19 pandemic. Here we present the conditional Long Short-Term Memory networks with Quantile output (condLSTM-Q), a well-performing model for making quantile predictions on COVID-19 death tolls at the county level with a two-week forecast window. This fine geographical scale is a rare but useful feature in publicly available predictive models, which would especially benefit state-level officials to coordinate resources within the state. The quantile predictions from …
We seek to evaluate the detection performance of a rapid primary screening tool of Covid-19 solely based on the cough sound from 8,380 clinically validated samples with laboratory molecular-test (2,339 Covid-19 positives and 6,041 Covid-19 negatives). Samples were clinically labeled according to the results and severity based on quantitative RT-PCR (qRT-PCR) analysis, cycle threshold, and lymphocytes count from the patients. Our proposed generic method is an algorithm based on Empirical Mode Decomposition (EMD) with subsequent classification based on a tensor of audio features and a deep artif…
One of the critical tools for early detection and subsequent evaluation of the incidence of lung diseases is chest radiography. This study presents a real-world implementation of a convolutional neural network (CNN) based Carebot Covid app to detect COVID-19 from chest X-ray (CXR) images. Our proposed model takes the form of a simple and intuitive application. Used CNN can be deployed as a STOW-RS prediction endpoint for direct implementation into DICOM viewers. The results of this study show that the deep learning model based on DenseNet and ResNet architecture can detect SARS-CoV-2 from CXR …
A Comprehensive Benchmark for COVID-19 Predictive Modeling Using Electronic Health Records in Intensive Care
University of Edinburgh（爱丁堡大学）；Health Data Research UK（英国健康数据研究中心）；Peking University（北京大学）；Peking University Third Hospital（北京大学第三医院）；Kaihong Digital（凯宏数字）
Computer Vision Center（计算机视觉中心）；Universitat Autònoma de Barcelona（巴塞罗那自治大学）
Future SARS-CoV-2 virus outbreak COVID-XX might possibly occur during the next years. However the pathology in humans is so recent that many clinical aspects, like early detection of complications, side effects after recovery or early screening, are currently unknown. In spite of the number of cases of COVID-19, its rapid spread putting many sanitary systems in the edge of collapse has hindered proper collection and analysis of the data related to COVID-19 clinical aspects. We describe an interdisciplinary initiative that integrates clinical research, with image diagnostics and the use of new …
COVID-19 clinical presentation and prognosis are highly variable, ranging from asymptomatic and paucisymptomatic cases to acute respiratory distress syndrome and multi-organ involvement. We developed a hybrid machine learning/deep learning model to classify patients in two outcome categories, non-ICU and ICU (intensive care admission or death), using 558 patients admitted in a northern Italy hospital in February/May of 2020. A fully 3D patient-level CNN classifier on baseline CT images is used as feature extractor. Features extracted, alongside with laboratory and clinical data, are fed for se…
COVID-19 severity is due to complications from SARS-Cov-2 but the clinical course of the infection varies for individuals, emphasizing the need to better understand the disease at the molecular level. We use clinical and multiple molecular data (or views) obtained from patients with and without COVID-19 who were (or not) admitted to the intensive care unit to shed light on COVID-19 severity. Methods for jointly associating the views and separating the COVID-19 groups (i.e., one-step methods) have focused on linear relationships. The relationships between the views and COVID-19 patient groups, …
Corona virus or COVID-19 is a pandemic illness, which has influenced more than million of causalities worldwide and infected a few large number of individuals .Innovative instrument empowering quick screening of the COVID-19 contamination with high precision can be critically useful to the medical care experts. The primary clinical device presently being used for the analysis of COVID-19 is the Reverse record polymerase chain response as known as RT-PCR, which is costly, less-delicate and requires specific clinical work force. X-Ray imaging is an effectively available apparatus that can be a g…
Background: COVID-19 has become a challenge worldwide and properly planning of medical resources is the key to combating COVID-19. In the US Veteran Affairs Health Care System (VA), many of the enrollees are susceptible to COVID-19. Predicting the COVID-19 to allocate medical resources promptly becomes a critical issue. When the VA enrollees have COVID-19 symptoms, it is recommended that their first step should be to call the VA Call Center. For confirmed COVID-19 patients, the median time from the first symptom to hospital admission was seven days. By predicting the number of COVID-19 related…
CovidLLM: A Robust Large Language Model with Missing Value Adaptation and Multi-Objective Learning Strategy for Predicting Disease Severity and Clinical Outcomes in COVID-19 Patients
School of Mathematics and Statistics, Xiamen University of Technology（厦门理工学院数学与统计学院）；School of Computer and Information Engineering, Xiamen University of Technology（厦门理工学院计算机与信息工程学院）；Tongji Medical College, Huazhong University of Science and Technology（华中科技大学同济医学院）
University of Waterloo（滑铁卢大学）；McGill University（麦吉尔大学）；St. Mary’s Hospital（圣玛丽医院）；Waterloo AI Institute（滑铁卢人工智能研究院）；DarwinAI Corp.（达尔文人工智能公司）
As the global population continues to face significant negative impact by the on-going COVID-19 pandemic, there has been an increasing usage of point-of-care ultrasound (POCUS) imaging as a low-cost and effective imaging modality of choice in the COVID-19 clinical workflow. A major barrier with widespread adoption of POCUS in the COVID-19 clinical workflow is the scarcity of expert clinicians that can interpret POCUS examinations, leading to considerable interest in deep learning-driven clinical decision support systems to tackle this challenge. A major challenge to building deep neural networ…
California State University Los Angeles（加州州立大学洛杉矶分校）；SoftZen Co. Ltd.（SoftZen有限公司）
COVID 19 is an acute disease that started spreading throughout the world, beginning in December 2019. It has spread worldwide and has affected more than 7 million people, and 200 thousand people have died due to this infection as of Oct 2020. In this paper, we have forecasted the number of deaths and the confirmed cases in Los Angeles and New York of the United States using the traditional and Big Data platforms based on the Times Series: ARIMA and ETS. We also implemented a more sophisticated time-series forecast model using Facebook Prophet API. Furthermore, we developed the classification m…
Bangabandhu Sheikh Mujibur Rahman Science & Technology University（班加班杜谢赫穆吉布·拉赫曼科技大学）；University of Rajshahi（拉杰沙希大学）；University of Technology Sydney（悉尼科技大学）；The University of Sydney（悉尼大学）；Jatiya Kabi Kazi Nazrul Islam University（贾蒂亚·卡比·卡齐·纳兹鲁尔·伊斯兰大学）；Imam Mohammad Ibn Saud Islamic University（伊玛目穆罕默德·伊本·沙特伊斯兰大学）；University of New South Wales（新南威尔士大学）；Deakin University（迪肯大学）；The Garvan Institute of Medical Research（加尔文医学研究所）
Introduction: For COVID-19 patients accurate prediction of disease severity and mortality risk would greatly improve care delivery and resource allocation. There are many patient-related factors, such as pre-existing comorbidities that affect disease severity. Since rapid automated profiling of peripheral blood samples is widely available, we investigated how such data from the peripheral blood of COVID-19 patients might be used to predict clinical outcomes. Methods: We thus investigated such clinical datasets from COVID-19 patients with known outcomes by combining statistical comparison and c…
CNN-LSTM Hybrid Model for AI-Driven Prediction of COVID-19 Severity from Spike Sequences and Clinical Data
Universidade Federal do Rio de Janeiro（巴西里约热内卢联邦大学）；Programa de Pós-graduação Multicêntrico em Ciências Fisiológicas（多中心生理科学硕士课程）；NUPEM / UFRJ - Instituto de Biodiversidade e Sustentabilidade（NUPEM/UFRJ - 生物多样性与可持续发展研究所）；Fundação Oswaldo Cruz (Fiocruz)（奥斯沃阿尔多·克鲁兹基金会）；Programa de Pós-Graduação Stricto sensu em Biologia Computacional e Sistemas（严格意义上的计算生物学和系统硕士课程）；Universidade Federal do Rio de Janiero（巴西里约热内卢联邦大学）
Machine Learning-driven Analysis of Gastrointestinal Symptoms in Post-COVID-19 Patients
College of Science, University of Al-Qadisiyah（卡迪西亚大学理学院）；Liverpool John Moors University（利物浦约翰摩尔大学）；College of Medicine, Kufa University（库法大学医学院）；Imperial College（帝国理工学院）；Al-Sadder Teaching Hospital（萨德尔教学医院）
With the present highly infectious dominant SARS-CoV-2 strain of B1.1.529 or Omicron spreading around the globe, there is concern that the COVID-19 pandemic will not end soon and that it will be a race against time until a more contagious and virulent variant emerges. One of the most promising approaches for preventing virus propagation is to maintain continuous high vaccination efficacy among the population, thereby strengthening the population protective effect and preventing the majority of infection in the vaccinated population, as is known to occur with the Omicron variant frequently. Cou…
Massachusetts General Hospital（麻省总医院）；Mass General Brigham（麻省百瀚医疗系统）；Harvard Medical School（哈佛医学院）
We developed MLHO (pronounced as melo), an end-to-end Machine Learning framework that leverages iterative feature and algorithm selection to predict Health Outcomes. MLHO implements iterative sequential representation mining, and feature and model selection, for predicting the patient-level risk of hospitalization, ICU admission, need for mechanical ventilation, and death. It bases this prediction on data from patients' past medical records (before their COVID-19 infection). MLHO's architecture enables a parallel and outcome-oriented model calibration, in which different statistical learning a…
In this paper, we propose a deep learning model to forecast the range of increase in COVID-19 infected cases in future days and we present a novel method to compute equidimensional representations of multivariate time series and multivariate spatial time series data. Using this novel method, the proposed model can both take in a large number of heterogeneous features, such as census data, intra-county mobility, inter-county mobility, social distancing data, past growth of infection, among others, and learn complex interactions between these features. Using data collected from various sources, …
Duke University School of Medicine（杜克大学医学院）；Duke University（杜克大学）；National Artificial Intelligence Institute, U.S. Dept. of Veterans Affairs（美国退伍军人事务部国家人工智能研究所）
Research studies of artificial intelligence models in medical imaging have been hampered by poor generalization. This problem has been especially concerning over the last year with numerous applications of deep learning for COVID-19 diagnosis. Virtual imaging trials (VITs) could provide a solution for objective evaluation of these models. In this work utilizing the VITs, we created the CVIT-COVID dataset including 180 virtually imaged computed tomography (CT) images from simulated COVID-19 and normal phantom models under different COVID-19 morphology and imaging properties. We evaluated the pe…
Emory University（埃默里大学）；Georgia Institute of Technology（佐治亚理工学院）
Although there has been significant research in boosting of weak learners, there has been little work in the field of boosting from strong learners. This latter paradigm is a form of weighted voting with learned weights. In this work, we consider the problem of constructing an ensemble algorithm from 70 individual algorithms for the early prediction of sepsis from clinical data. We find that this ensemble algorithm outperforms separate algorithms, especially on a hidden test set on which most algorithms failed to generalize.
University of Waterloo（滑铁卢大学）；Waterloo Artificial Intelligence Institute（滑铁卢人工智能研究所）；DarwinAI Corp.（DarwinAI公司）；McMaster University（麦克马斯特大学）；Thunder Bay Regional Health Sciences Centre（桑德贝地区健康科学中心）；Northern Ontario School of Medicine（北安大略医学院）
As the COVID-19 pandemic continues to devastate globally, the use of chest X-ray (CXR) imaging as a complimentary screening strategy to RT-PCR testing continues to grow given its routine clinical use for respiratory complaint. As part of the COVID-Net open source initiative, we introduce COVID-Net CXR-2, an enhanced deep convolutional neural network design for COVID-19 detection from CXR images built using a greater quantity and diversity of patients than the original COVID-Net. To facilitate this, we also introduce a new benchmark dataset composed of 19,203 CXR images from a multinational coh…
NYU Abu Dhabi（纽约大学阿布扎比分校）；Abu Dhabi Health Services（阿布扎比医疗服务公司）；G42 Healthcare（G42医疗）
Existing prognostic tools mainly focus on predicting the risk of mortality among patients with coronavirus disease 2019. However, clinical evidence suggests that COVID-19 can result in non-mortal complications that affect patient prognosis. To support patient risk stratification, we aimed to develop a prognostic system that predicts complications common to COVID-19. In this retrospective study, we used data collected from 3,352 COVID-19 patient encounters admitted to 18 facilities between April 1 and April 30, 2020, in Abu Dhabi (AD), UAE. The hospitals were split based on geographical proximi…
Qatar University（卡塔尔大学）；North South University（北南大学）；University of South Carolina（南卡罗来纳大学）；Hamad General Hospital（哈马德综合医院）；AFG College with the University of Aberdeen（阿伯丁大学AFG学院）
Fast and accurate detection of the disease can significantly help in reducing the strain on the healthcare facility of any country to reduce the mortality during any pandemic. The goal of this work is to create a multimodal system using a novel machine learning framework that uses both Chest X-ray (CXR) images and clinical data to predict severity in COVID-19 patients. In addition, the study presents a nomogram-based scoring technique for predicting the likelihood of death in high-risk patients. This study uses 25 biomarkers and CXR images in predicting the risk in 930 COVID-19 patients admitt…
University of Minnesota, Twin Cities（明尼苏达大学双城分校）；Allina Health（阿利纳医疗）
Leading up to August 2020, COVID-19 has spread to almost every country in the world, causing millions of infected and hundreds of thousands of deaths. In this paper, we first verify the assumption that clinical variables could have time-varying effects on COVID-19 outcomes. Then, we develop a temporal stratification approach to make daily predictions on patients' outcome at the end of hospital stay. Training data is segmented by the remaining length of stay, which is a proxy for the patient's overall condition. Based on this, a sequence of predictive models are built, one for each time segment…
University of Waterloo（滑铁卢大学）；National Research Council Canada（加拿大国家研究委员会）；Oakville Trafalgar Memorial Hospital（奥克维尔特拉法加纪念医院）；McMaster University（麦克马斯特大学）；Waterloo Artificial Intelligence Institute（滑铁卢人工智能研究所）
The Coronavirus Disease 2019 (COVID-19) pandemic has impacted many aspects of life globally, and a critical factor in mitigating its effects is screening individuals for infections, thereby allowing for both proper treatment for those individuals as well as action to be taken to prevent further spread of the virus. Point-of-care ultrasound (POCUS) imaging has been proposed as a screening tool as it is a much cheaper and easier to apply imaging modality than others that are traditionally used for pulmonary examinations, namely chest x-ray and computed tomography. Given the scarcity of expert ra…
University Campus Bio-Medico of Rome（罗马生物医学自由大学）；Centro Diagnostico Italiano S.p.A.（意大利诊断中心股份公司）；Istituto Italiano di Tecnologia（意大利理工学院）；Bracco Imaging S.p.A.（博莱科影像股份公司）；Sapienza University of Rome（罗马大学）；Fondazione IRCCS Policlinico San Matteo（圣马泰奥综合医院IRCCS基金会）
Recent epidemiological data report that worldwide more than 53 million people have been infected by SARS-CoV-2, resulting in 1.3 million deaths. The disease has been spreading very rapidly and few months after the identification of the first infected, shortage of hospital resources quickly became a problem. In this work we investigate whether chest X-ray (CXR) can be used as a possible tool for the early identification of patients at risk of severe outcome, like intensive care or death. CXR is a radiological technique that compared to computed tomography (CT) it is simpler, faster, more widesp…
Stony Brook University（石溪大学）；Newark Beth Israel Medical Center（纽瓦克贝丝以色列医疗中心）；University Hospitals Cleveland Medical Center（大学医院克利夫兰医疗中心）
We predict mechanical ventilation requirement and mortality using computational modeling of chest radiographs (CXRs) for coronavirus disease 2019 (COVID-19) patients. This two-center, retrospective study analyzed 530 deidentified CXRs from 515 COVID-19 patients treated at Stony Brook University Hospital and Newark Beth Israel Medical Center between March and August 2020. DL and machine learning classifiers to predict mechanical ventilation requirement and mortality were trained and evaluated using patient CXRs. A novel radiomic embedding framework was also explored for outcome prediction. All …
Massachusetts Institute of Technology（麻省理工学院）；Harvard University（哈佛大学）；Universitat de Barcelona（巴塞罗那大学）；Instituto de Salud Carlos III（卡洛斯三世卫生研究所）；Hospital Universitari Germans Trias i Pujol（Germans Trias i Pujol大学医院）；Universidad de Guadalajara（瓜达拉哈拉大学）；Centro Universitario de Ciencias de la Salud（健康科学中心大学学院）；OPD Hospital Civil de Guadalajara（瓜达拉哈拉市立医院）
Just like your phone can detect what song is playing in crowded spaces, we show that Artificial Intelligence transfer learning algorithms trained on cough phone recordings results in diagnostic tests for COVID-19. To gain adoption by the health care community, we plan to validate our results in a clinical trial and three other venues in Mexico, Spain and the USA . However, if we had data from other on-going clinical trials and volunteers, we may do much more. For example, for confirmed stay-at-home COVID-19 patients, a longitudinal audio test could be developed to determine contact-with-hospit…
Predicting Cardiovascular Complications in Post-COVID-19 Patients Using Data-Driven Machine Learning Models
College of Science, University of Al-Qadisiyah（卡迪西亚大学理学院）；Liverpool John Moors University（利物浦约翰摩尔大学）；Specialist in Internal Medicine - Pulmonary Disease（内科及肺科专科医师机构）
Hospital of Wuhan Red Cross Society（武汉红十字会医院）；Institute of Biomedical Engineering, University of Oxford（牛津大学生物医学工程研究所）；Aladdin Healthcare Technologies Ltd（阿拉丁医疗科技有限公司）；Hangzhou Ocean's Smart Boya Co., Ltd（杭州奥盛博雅智能科技有限公司）；Mind Rank Ltd（Mind Rank有限公司）；IIAT；University of Oslo（奥斯陆大学）；Shenzhen Second People’s Hospital（深圳市第二人民医院）；Hunan Cancer Hospital（湖南省肿瘤医院）；NHLI, Imperial College London（伦敦帝国理工学院国家心肺研究所）；Royal Brompton Hospital（皇家布朗普顿医院）
An outbreak of a novel coronavirus disease (i.e., COVID-19) has been recorded in Wuhan, China since late December 2019, which subsequently became pandemic around the world. Although COVID-19 is an acutely treated disease, it can also be fatal with a risk of fatality of 4.03% in China and the highest of 13.04% in Algeria and 12.67% Italy (as of 8th April 2020). The onset of serious illness may result in death as a consequence of substantial alveolar damage and progressive respiratory failure. Although laboratory testing, e.g., using reverse transcription polymerase chain reaction (RT-PCR), is t…
Critical Appraisal of Fairness Metrics in Clinical Predictive AI
University of Oxford（牛津大学）；KU Leuven（鲁汶大学）；Beth Israel Deaconess Medical Center（贝斯以色列女执事医疗中心）；Massachusetts Institute of Technology（麻省理工学院）；Harvard T H Chan School of Public Health（哈佛大学陈曾熙公共卫生学院）；Emory University（埃默里大学）；University of Birmingham（伯明翰大学）
Adversarial Fragility and Language Vulnerability in Clinical AI: A Systematic Audit of Diagnostic Collapse Under Imperceptible Perturbations and Cross-Lingual Drift in Low-Resource Healthcare Settings
Centre for Clinical Intelligence & Safety（临床智能与安全中心）；Tomorrow University of Applied Sciences（明天应用科学大学）
University of Minnesota（明尼苏达大学）；Emory University（埃默里大学）；M Health Fairview Informatics（M Health Fairview 信息学）；Indiana University（印第安纳大学）；North Memorial Health Hospital（North Memorial Health 医院）
Importance: An artificial intelligence (AI)-based model to predict COVID-19 likelihood from chest x-ray (CXR) findings can serve as an important adjunct to accelerate immediate clinical decision making and improve clinical decision making. Despite significant efforts, many limitations and biases exist in previously developed AI diagnostic models for COVID-19. Utilizing a large set of local and international CXR images, we developed an AI model with high performance on temporal and external validation. Conclusions and Relevance: AI-based diagnostic tools may serve as an adjunct, but not replace…
From Data Lifting to Continuous Risk Estimation: A Process-Aware Pipeline for Predictive Monitoring of Clinical Pathways
Department of Informatics, University of Bari Aldo Moro（巴里阿尔多·莫罗大学信息学院）；Department of Engineering, University of Sannio（萨尼奥大学工程学院）；Department of Economy and Law, UnitelmaSapienza University（单位elma萨皮恩扎大学经济法学院）
F. Hoffmann-La Roche Ltd（罗氏制药公司）；Max Planck Institute for Intelligent Systems（马克斯·普朗克智能系统研究所）；ETH Zurich（苏黎世联邦理工学院）；John A. Paulson School of Engineering and Applied Sciences, Harvard University（哈佛大学约翰·A·保尔森工程与应用科学学院）；Beth Israel Deaconess Medical Center, Harvard Medical School（哈佛医学院贝斯以色列女执事医疗中心）；MIT Critical Data, Laboratory for Computational Physiology, Institute for Medical Engineering and Science, Harvard-MIT Health Sciences & Technology（哈佛-麻省理工健康科学与技术研究所医学工程与科学研究所计算生理学实验室MIT关键数据）；University Hospital of Tübingen（蒂宾根大学医院）；Kantonsspital Winterthur（温特图尔州立医院）
Coronavirus Disease 2019 (COVID-19) is an emerging respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with rapid human-to-human transmission and a high case fatality rate particularly in older patients. Due to the exponential growth of infections, many healthcare systems across the world are under pressure to care for increasing amounts of at-risk patients. Given the high number of infected patients, identifying patients with the highest mortality risk early is critical to enable effective intervention and optimal prioritisation of care. Here, we pre…
Stanford University（斯坦福大学）；Massachusetts Institute of Technology（麻省理工学院）；Beth Israel Deaconess Medical Center（贝斯以色列女执事医疗中心）；Fundacion Progreso y Salud（进步与健康基金会）；National Tsing Hua University（台湾清华大学）；Albert Einstein Medical Center（阿尔伯特·爱因斯坦医疗中心）；Memorial Sloan Kettering Cancer Center（纪念斯隆·凯特琳癌症中心）；National University Hospital（新加坡国立大学医院）；Hoboken University Medical Center–CarePoint Health（霍博肯大学医疗中心-CarePoint Health）；Hospital Universitario Monteprincipe（蒙特普林西比大学医院）；Grupo HM Hospitales（HM医院集团）；Seoul National University College of Medicine（首尔大学医学院）；Centro Nacional de Investigaciones Cardiovasculares（国家心血管研究中心）；Instituto de Salud Carlos III（卡洛斯三世健康研究所）；Harvard T.H. Chan School of Public Health（哈佛大学陈曾熙公共卫生学院）
The unprecedented global crisis brought about by the COVID-19 pandemic has sparked numerous efforts to create predictive models for the detection and prognostication of SARS-CoV-2 infections with the goal of helping health systems allocate resources. Machine learning models, in particular, hold promise for their ability to leverage patient clinical information and medical images for prediction. However, most of the published COVID-19 prediction models thus far have little clinical utility due to methodological flaws and lack of appropriate validation. In this paper, we describe our methodology…
In this work, we modify and apply self-supervision techniques to the domain of medical health insurance claims. We model patients' healthcare claims history analogous to free-text narratives, and introduce pre-trained `prior knowledge', later utilized for patient outcome predictions on a challenging task: predicting Covid-19 hospitalization, given a patient's pre-Covid-19 insurance claims history. Results suggest that pre-training on insurance claims not only produces better prediction performance, but, more importantly, improves the model's `clinical trustworthiness' and model stability/relia…
